Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/22845 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. |
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Mir, DaianaDelatorre, EdsonBonaldo, MyrnaOliveira, Ricardo Lourenço deVicente, Ana CarolinaBello, Gonzalo2017-10-17T15:04:14Z2017-10-17T15:04:14Z2017MIR, Daiana; et al. Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak. Scientifc Reports, v.7:7385, 9p, Aug. 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2284510.1038/s41598-017-07873-7engNature Publishing GroupVírus da Febre AmarelaAméricasSurtoBrasilGenótiposFilodinâmicaYellow fever virusAmericasBrazilian OutbreakBrazilgenotypesPhylodinamicsPhylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreakinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Yellow fever virus (YFV) strains circulating in the Americas belong to two distinct genotypes (I and II) that have diversified into several concurrent enzootic lineages. Since 1999, YFV genotype I has spread outside endemic regions and its recent (2017) reemergence in non-endemic Southeastern Brazilian states fuels one of the largest epizootic of jungle Yellow Fever registered in the country. To better understand this phenomenon, we reconstructed the phylodynamics of YFV American genotypes using sequences from nine countries sampled along 60 years, including strains from Brazilian 2017 outbreak. Our analyses reveals that YFV genotypes I and II follow roughly similar evolutionary and demographic dynamics until the early 1990s, when a dramatic change in the diversification process of the genotype I occurred associated with the emergence and dissemination of a new lineage (here called modern). Trinidad and Tobago was the most likely source of the YFV modern-lineage that spread to Brazil and Venezuela around the late 1980s, where it replaced all lineages previously circulating. The modern-lineage caused all major YFV outbreaks detected in non-endemic South American regions since 2000, including the 2017 Brazilian outbreak, and its dissemination was coupled to the accumulation of several amino acid substitutions particularly within non-structural viral proteins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22845/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdaiana_mir_etal_IOC_2017.pdfdaiana_mir_etal_IOC_2017.pdfapplication/pdf1957551https://www.arca.fiocruz.br/bitstream/icict/22845/2/daiana_mir_etal_IOC_2017.pdf12a92f78884535aba9718d2db12e76b9MD52TEXTdaiana_mir_etal_IOC_2017.pdf.txtdaiana_mir_etal_IOC_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| title |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| spellingShingle |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak Mir, Daiana Vírus da Febre Amarela Américas Surto Brasil Genótipos Filodinâmica Yellow fever virus Americas Brazilian Outbreak Brazil genotypes Phylodinamics |
| title_short |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| title_full |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| title_fullStr |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| title_full_unstemmed |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| title_sort |
Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak |
| author |
Mir, Daiana |
| author_facet |
Mir, Daiana Delatorre, Edson Bonaldo, Myrna Oliveira, Ricardo Lourenço de Vicente, Ana Carolina Bello, Gonzalo |
| author_role |
author |
| author2 |
Delatorre, Edson Bonaldo, Myrna Oliveira, Ricardo Lourenço de Vicente, Ana Carolina Bello, Gonzalo |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Mir, Daiana Delatorre, Edson Bonaldo, Myrna Oliveira, Ricardo Lourenço de Vicente, Ana Carolina Bello, Gonzalo |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Febre Amarela Américas Surto Brasil Genótipos Filodinâmica |
| topic |
Vírus da Febre Amarela Américas Surto Brasil Genótipos Filodinâmica Yellow fever virus Americas Brazilian Outbreak Brazil genotypes Phylodinamics |
| dc.subject.en.pt_BR.fl_str_mv |
Yellow fever virus Americas Brazilian Outbreak Brazil genotypes Phylodinamics |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. |
| publishDate |
2017 |
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2017-10-17T15:04:14Z |
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2017-10-17T15:04:14Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MIR, Daiana; et al. Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak. Scientifc Reports, v.7:7385, 9p, Aug. 2017. |
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https://www.arca.fiocruz.br/handle/icict/22845 |
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2045-2322 |
| dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-017-07873-7 |
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MIR, Daiana; et al. Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak. Scientifc Reports, v.7:7385, 9p, Aug. 2017. 2045-2322 10.1038/s41598-017-07873-7 |
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Nature Publishing Group |
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Nature Publishing Group |
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