Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | spa |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/0074-02760170134 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18447 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. |
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Bonaldo, Myrna C.Gómez, Mariela MartínezSantos, Alexandre A. C. dosAbreu, Filipe Vieira Santos deBrito, Anielly Ferreira deMiranda, Rafaella Moraes deCastro, Marcia Gonçalves deOliveira, Ricardo Lourenço de2017-04-15T14:16:00Z2017-04-15T14:16:00Z2017BONALDO, Myrna C. et al. Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphism. Mem Inst Oswaldo Cruz. E-pub: 4 Apr 2017.1678-8080https://www.arca.fiocruz.br/handle/icict/1844710.1590/0074-02760170134spaFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Vpirus da febre amarelaSurto de 2017 no Brasilalterações de aminoácidosyellow fever virus2017 Brazil outbreakamino acids changesGenome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphismsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil / Instituto Federal do Norte de Minas Gerais. MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, BrasilThe current yellow fever (YF) outbreak in Brazil is the most severe recently reported in the country. It has rapidly spread to areas where YF viral activity have not been observed for more than seventy years and vaccine coverage is almost null. Here, we sequenced the whole YF genome of two naturally infected howler-monkeys (Alouatta clamitans) from the Municipality of Domingos Martins, State of Espírito Santo, Brazil. The ongoing-outbreak genome sequences are identical. They clustered in 1E sub-clade (South America I genotype) together with recent Brazilian and Venezuelan strains characterized from infections in humans and non-humans primates. However, we detected eight unique amino acid changes in the viral proteins, which are located in the structural capsid protein (1 change), and the components of viral replicase complex, the NS3 (2 changes) and NS5 (5 changes) proteins, suggesting a potential role in the capacity of viral infection to vertebrate and/or invertebrate hosts and spreading in the ongoing outbreak.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18447/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmyrna_bonaldo_etal_IOC_2017.pdfmyrna_bonaldo_etal_IOC_2017.pdfapplication/pdf984162https://www.arca.fiocruz.br/bitstream/icict/18447/2/myrna_bonaldo_etal_IOC_2017.pdf20aee3932135122c8774a8618634261bMD52TEXTmyrna_bonaldo_etal_IOC_2017.pdf.txtmyrna_bonaldo_etal_IOC_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| title |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| spellingShingle |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms Bonaldo, Myrna C. Vpirus da febre amarela Surto de 2017 no Brasil alterações de aminoácidos yellow fever virus 2017 Brazil outbreak amino acids changes |
| title_short |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| title_full |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| title_fullStr |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| title_full_unstemmed |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| title_sort |
Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms |
| author |
Bonaldo, Myrna C. |
| author_facet |
Bonaldo, Myrna C. Gómez, Mariela Martínez Santos, Alexandre A. C. dos Abreu, Filipe Vieira Santos de Brito, Anielly Ferreira de Miranda, Rafaella Moraes de Castro, Marcia Gonçalves de Oliveira, Ricardo Lourenço de |
| author_role |
author |
| author2 |
Gómez, Mariela Martínez Santos, Alexandre A. C. dos Abreu, Filipe Vieira Santos de Brito, Anielly Ferreira de Miranda, Rafaella Moraes de Castro, Marcia Gonçalves de Oliveira, Ricardo Lourenço de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bonaldo, Myrna C. Gómez, Mariela Martínez Santos, Alexandre A. C. dos Abreu, Filipe Vieira Santos de Brito, Anielly Ferreira de Miranda, Rafaella Moraes de Castro, Marcia Gonçalves de Oliveira, Ricardo Lourenço de |
| dc.subject.other.pt_BR.fl_str_mv |
Vpirus da febre amarela Surto de 2017 no Brasil alterações de aminoácidos |
| topic |
Vpirus da febre amarela Surto de 2017 no Brasil alterações de aminoácidos yellow fever virus 2017 Brazil outbreak amino acids changes |
| dc.subject.en.pt_BR.fl_str_mv |
yellow fever virus 2017 Brazil outbreak amino acids changes |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017-04-15T14:16:00Z |
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2017-04-15T14:16:00Z |
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2017 |
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info:eu-repo/semantics/article |
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BONALDO, Myrna C. et al. Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphism. Mem Inst Oswaldo Cruz. E-pub: 4 Apr 2017. |
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https://www.arca.fiocruz.br/handle/icict/18447 |
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1678-8080 |
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10.1590/0074-02760170134 |
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BONALDO, Myrna C. et al. Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphism. Mem Inst Oswaldo Cruz. E-pub: 4 Apr 2017. 1678-8080 10.1590/0074-02760170134 |
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