IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19344 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. |
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Franca, Rafael F. O.Costa, Renata S.Silva, Jaqueline R.Peres, Raphael S.Mendonça, Leila R.Colón, David F.Alves-Filho, José CarlosCunha, Fernando Q.2017-06-07T19:06:59Z2017-06-07T19:06:59Z2016FRANCA, R. F. O. et al. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Journal of Neuroinflammation, v. 13, n. 1, dez. 2016.1742-2094https://www.arca.fiocruz.br/handle/icict/1934410.1186/s12974-016-0628-1engInterleucina 33Receptor ST2Encefalite viral experimentalÓxido nítricoFlavivirusInterleukin 33ST2 receptorExperimental viral encephalitisNitric oxideFlavivirusSistema Nervoso Central / imunologiaSistema Nervoso Central / patologiaSistema Nervoso Central / virologiaEncefalite Viral / patologiaInterleucina-33 / metabolismoÓxido Nítrico Sintase Tipo II / metabolismoIL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous systeminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.University of São Paulo. Program of Basic and Applied Immunology. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto School of Medicine. Department of Pharmacology. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto School of Medicine. Department of Pharmacology. Ribeirão Preto, SP, Brazil.Viral encephalitis is a common cause of lethal infections in humans, and several different viruses are documented to be responsible. Rocio virus is a flavivirus that causes a severe lethal encephalitis syndrome in humans and also mice, providing an interesting model to study the CNS compartmentalized immune response. Interleukin 33 (IL-33), a member of the IL-1 family, is an immunomodulatory cytokine that is highly expressed in the CNS. However, the role of IL-33 on viral encephalitis remains unclear. Therefore, we aimed to explore how the IL-33/ST2 axis regulates the local immune response during Rocio virus infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19344/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL27334012 2016 fra-il3.oa.pdf27334012 2016 fra-il3.oa.pdfapplication/pdf4008863https://www.arca.fiocruz.br/bitstream/icict/19344/2/27334012%202016%20fra-il3.oa.pdf03f33f4a9fd3a6e63fe6691315a03b70MD52TEXT27334012 2016 fra-il3.oa.pdf.txt27334012 2016 fra-il3.oa.pdf.txtExtracted texttext/plain59457https://www.arca.fiocruz.br/bitstream/icict/19344/3/27334012%202016%20fra-il3.oa.pdf.txt80d86f4dfaa9de8500c2ac8d7611173aMD53icict/193442018-08-15 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| dc.title.pt_BR.fl_str_mv |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| title |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| spellingShingle |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system Franca, Rafael F. O. Interleucina 33 Receptor ST2 Encefalite viral experimental Óxido nítrico Flavivirus Interleukin 33 ST2 receptor Experimental viral encephalitis Nitric oxide Flavivirus Sistema Nervoso Central / imunologia Sistema Nervoso Central / patologia Sistema Nervoso Central / virologia Encefalite Viral / patologia Interleucina-33 / metabolismo Óxido Nítrico Sintase Tipo II / metabolismo |
| title_short |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| title_full |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| title_fullStr |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| title_full_unstemmed |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| title_sort |
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system |
| author |
Franca, Rafael F. O. |
| author_facet |
Franca, Rafael F. O. Costa, Renata S. Silva, Jaqueline R. Peres, Raphael S. Mendonça, Leila R. Colón, David F. Alves-Filho, José Carlos Cunha, Fernando Q. |
| author_role |
author |
| author2 |
Costa, Renata S. Silva, Jaqueline R. Peres, Raphael S. Mendonça, Leila R. Colón, David F. Alves-Filho, José Carlos Cunha, Fernando Q. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Franca, Rafael F. O. Costa, Renata S. Silva, Jaqueline R. Peres, Raphael S. Mendonça, Leila R. Colón, David F. Alves-Filho, José Carlos Cunha, Fernando Q. |
| dc.subject.other.none.fl_str_mv |
Interleucina 33 Receptor ST2 Encefalite viral experimental Óxido nítrico Flavivirus |
| topic |
Interleucina 33 Receptor ST2 Encefalite viral experimental Óxido nítrico Flavivirus Interleukin 33 ST2 receptor Experimental viral encephalitis Nitric oxide Flavivirus Sistema Nervoso Central / imunologia Sistema Nervoso Central / patologia Sistema Nervoso Central / virologia Encefalite Viral / patologia Interleucina-33 / metabolismo Óxido Nítrico Sintase Tipo II / metabolismo |
| dc.subject.en.none.fl_str_mv |
Interleukin 33 ST2 receptor Experimental viral encephalitis Nitric oxide Flavivirus |
| dc.subject.decs.none.fl_str_mv |
Sistema Nervoso Central / imunologia Sistema Nervoso Central / patologia Sistema Nervoso Central / virologia Encefalite Viral / patologia Interleucina-33 / metabolismo Óxido Nítrico Sintase Tipo II / metabolismo |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. |
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2016 |
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2016 |
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2017-06-07T19:06:59Z |
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2017-06-07T19:06:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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FRANCA, R. F. O. et al. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Journal of Neuroinflammation, v. 13, n. 1, dez. 2016. |
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https://www.arca.fiocruz.br/handle/icict/19344 |
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1742-2094 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/s12974-016-0628-1 |
| identifier_str_mv |
FRANCA, R. F. O. et al. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Journal of Neuroinflammation, v. 13, n. 1, dez. 2016. 1742-2094 10.1186/s12974-016-0628-1 |
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