Adesivo odontológico com microesferas contendo clorexidina

Detalhes bibliográficos
Autor(a) principal: Fonseca, Amanda
Data de Publicação: 2020
Outros Autores: Julião, Lucas
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório do Centro Universitário Braz Cubas
Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/1352
Resumo: Although resin-based restorations have acceptable life rates, it is noted that dental surgeons still spend significant clinical time replacing failed restorations. The restorative durability can be compromised by the degradation of the adhesive interface that occurs both by the hydrolytic degradation of the adhesive resin and by the enzymatic action acting on the exposed collagen fibers. In this sense, the incorporation of microspheres containing chlorhexidine in adhesives can improve the properties of the material, preventing the activation of the metalloproteinase enzyme (MMPs) that degrades the collagen network causing failures in adhesive restorations. Chlorhexidine can be an alternative to be incorporated into adhesives. The aim of the present study was to develop a resinous adhesive, incorporating microspheres containing chlorhexidine and further characterizing the properties of the resulting material.
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spelling Adesivo odontológico com microesferas contendo clorexidinaClorexidinaMicroesferasAdesão dentinária4.02.00.00-0 OdontologiaAlthough resin-based restorations have acceptable life rates, it is noted that dental surgeons still spend significant clinical time replacing failed restorations. The restorative durability can be compromised by the degradation of the adhesive interface that occurs both by the hydrolytic degradation of the adhesive resin and by the enzymatic action acting on the exposed collagen fibers. In this sense, the incorporation of microspheres containing chlorhexidine in adhesives can improve the properties of the material, preventing the activation of the metalloproteinase enzyme (MMPs) that degrades the collagen network causing failures in adhesive restorations. Chlorhexidine can be an alternative to be incorporated into adhesives. The aim of the present study was to develop a resinous adhesive, incorporating microspheres containing chlorhexidine and further characterizing the properties of the resulting material.Agência 1Embora as restaurações à base de resina tenham taxas de duração aceitáveis nota-se que os cirurgiões dentistas ainda gastam um tempo clínico significativo substituindo restaurações que falharam. A durabilidade restauradora pode ser comprometida pela degradação da interface adesiva que ocorre tanto pela degradação hidrolítica da resina adesiva quanto pela ação enzimática atuantes nas fibras de colágenos expostas. Nesse sentido, a incorporação de microesferas contendo clorexidina em adesivos podem aperfeiçoar as propriedades do material, prevenindo a ativação da enzima metaloproteinase(MMPs) que degrada a rede de colágeno causando falhas em restaurações adesivas. A clorexidina pode ser uma alternativa a ser incorporada aos adesivos. O objetivo do presente estudo foi desenvolver um adesivo resinoso, com a incorporação de microesferas contendo clorexidina e a posterior caracterização das propriedades do material resultante.Centro de Ensino Unificado do Distrito FederalBrasilCoordenação do Curso de OdontologiaUDFGenari, Bruna1089857614409767http://lattes.cnpq.br/1089857614409767Fonseca, AmandaJulião, Lucas2021-01-25T18:05:31Z2021-01-252021-01-25T18:05:31Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/1352por1. Fonseca BM, Pleffken PR, Balducci I, et al. New trends in dentin bonding: treatment with Chlorhexidine, Hyaluronic acid, vitamin C and green tea. Braz Dent Sci 2013 jul/set; 16 (3). 2. Ortiz-Ruiz AJ, Teruel-Fernandéz JD, Rubio LAA, et al. Structural differences in enamel and dentin in human, bovine, porcine, and ovine teeth. Aanat 2018 jul. 3. Cardoso MV, Neves AA, Mine A, et al. Current aspects on bonding effectiveness and stability in adhesive dentistry. Aust Dent J. 2011jun . 4. Marsawa N, Mohamed A, Abou-Rabii A, et al. Longevity of Self-Etch Dentin Bonding Adhesives compared to Etch-and-Rinse Dentin Bonding Adhesives: A Systematic Review. J Evid Based Dent Pract. 2016 Jun. 5. Mazzoni A, Tjaderhane L, Checchi V, et al. Role of dentin MMPs in caries progression and bond stability. J. Dent Res 2015 Feb. 6. Breschi L, Maravic T, Comba A, et al. Chlorhexidine preserves the hybrid layer in vitro after 10-years aging. Dent Mart 2020. 7. Junior VES, Lyra JDG, Silva MB, et al. Mechanism of action of chlorhexidine on metalloproteinase enzymes and their clinical impact: a review study.RFO UPF vol.21 nº3. Passo Fundo Set./Dez. 2016. 8. Haseeb R, Lau M, Sheah M. Synthesis and Characterization of New ChlorhexidineContaining Nanoparticles for Root Canal Disinfection. Materials 2016. 9. Schaffazick, S. R. et al. Caracterização e Estabilidade Físico-química de Sistemas Poliméricos Nanoparticulados para Administração de Fármacos. Quim. Nova, v. 26, n. 5, p. 726-737, 2003. 10- Souto E.B; Severino P.; Santana M.H.A. Preparação de nanopartículas poliméricas a partir da polimerização de monômeros-Parte I. Polímeros.Fev 2012, vol.22, págs 96-100. 11. Frank, L. A. et al. Improving drug biological effects by encapsulation into polymeric nanocapsules. WIREs Nanomed Nanobiotechnol, v. 7, n. 5, p. 623- 639, September/October 2015. 12. DOMINGUES, G. S. et al. Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica. Quim. Nova, v. 31, n. 8, p. 1966-1972, 2008. 13. Jain, D.; Panda, A. K.; Majumdar, D. K. Eudragit S100 Entrapped Insulin Microspheres for Oral Delivery. AAPS PharmSciTech, v. 6, n. 1, p. 101-107, 2005.info:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-01-29T21:14:45Zoai:repositorio.cruzeirodosul.edu.br:123456789/1352Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-01-29T21:14:45Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false
dc.title.none.fl_str_mv Adesivo odontológico com microesferas contendo clorexidina
title Adesivo odontológico com microesferas contendo clorexidina
spellingShingle Adesivo odontológico com microesferas contendo clorexidina
Fonseca, Amanda
Clorexidina
Microesferas
Adesão dentinária
4.02.00.00-0 Odontologia
title_short Adesivo odontológico com microesferas contendo clorexidina
title_full Adesivo odontológico com microesferas contendo clorexidina
title_fullStr Adesivo odontológico com microesferas contendo clorexidina
title_full_unstemmed Adesivo odontológico com microesferas contendo clorexidina
title_sort Adesivo odontológico com microesferas contendo clorexidina
author Fonseca, Amanda
author_facet Fonseca, Amanda
Julião, Lucas
author_role author
author2 Julião, Lucas
author2_role author
dc.contributor.none.fl_str_mv Genari, Bruna
1089857614409767
http://lattes.cnpq.br/1089857614409767
dc.contributor.author.fl_str_mv Fonseca, Amanda
Julião, Lucas
dc.subject.por.fl_str_mv Clorexidina
Microesferas
Adesão dentinária
4.02.00.00-0 Odontologia
topic Clorexidina
Microesferas
Adesão dentinária
4.02.00.00-0 Odontologia
description Although resin-based restorations have acceptable life rates, it is noted that dental surgeons still spend significant clinical time replacing failed restorations. The restorative durability can be compromised by the degradation of the adhesive interface that occurs both by the hydrolytic degradation of the adhesive resin and by the enzymatic action acting on the exposed collagen fibers. In this sense, the incorporation of microspheres containing chlorhexidine in adhesives can improve the properties of the material, preventing the activation of the metalloproteinase enzyme (MMPs) that degrades the collagen network causing failures in adhesive restorations. Chlorhexidine can be an alternative to be incorporated into adhesives. The aim of the present study was to develop a resinous adhesive, incorporating microspheres containing chlorhexidine and further characterizing the properties of the resulting material.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021-01-25T18:05:31Z
2021-01-25
2021-01-25T18:05:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.cruzeirodosul.edu.br/handle/123456789/1352
url https://repositorio.cruzeirodosul.edu.br/handle/123456789/1352
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 1. Fonseca BM, Pleffken PR, Balducci I, et al. New trends in dentin bonding: treatment with Chlorhexidine, Hyaluronic acid, vitamin C and green tea. Braz Dent Sci 2013 jul/set; 16 (3). 2. Ortiz-Ruiz AJ, Teruel-Fernandéz JD, Rubio LAA, et al. Structural differences in enamel and dentin in human, bovine, porcine, and ovine teeth. Aanat 2018 jul. 3. Cardoso MV, Neves AA, Mine A, et al. Current aspects on bonding effectiveness and stability in adhesive dentistry. Aust Dent J. 2011jun . 4. Marsawa N, Mohamed A, Abou-Rabii A, et al. Longevity of Self-Etch Dentin Bonding Adhesives compared to Etch-and-Rinse Dentin Bonding Adhesives: A Systematic Review. J Evid Based Dent Pract. 2016 Jun. 5. Mazzoni A, Tjaderhane L, Checchi V, et al. Role of dentin MMPs in caries progression and bond stability. J. Dent Res 2015 Feb. 6. Breschi L, Maravic T, Comba A, et al. Chlorhexidine preserves the hybrid layer in vitro after 10-years aging. Dent Mart 2020. 7. Junior VES, Lyra JDG, Silva MB, et al. Mechanism of action of chlorhexidine on metalloproteinase enzymes and their clinical impact: a review study.RFO UPF vol.21 nº3. Passo Fundo Set./Dez. 2016. 8. Haseeb R, Lau M, Sheah M. Synthesis and Characterization of New ChlorhexidineContaining Nanoparticles for Root Canal Disinfection. Materials 2016. 9. Schaffazick, S. R. et al. Caracterização e Estabilidade Físico-química de Sistemas Poliméricos Nanoparticulados para Administração de Fármacos. Quim. Nova, v. 26, n. 5, p. 726-737, 2003. 10- Souto E.B; Severino P.; Santana M.H.A. Preparação de nanopartículas poliméricas a partir da polimerização de monômeros-Parte I. Polímeros.Fev 2012, vol.22, págs 96-100. 11. Frank, L. A. et al. Improving drug biological effects by encapsulation into polymeric nanocapsules. WIREs Nanomed Nanobiotechnol, v. 7, n. 5, p. 623- 639, September/October 2015. 12. DOMINGUES, G. S. et al. Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica. Quim. Nova, v. 31, n. 8, p. 1966-1972, 2008. 13. Jain, D.; Panda, A. K.; Majumdar, D. K. Eudragit S100 Entrapped Insulin Microspheres for Oral Delivery. AAPS PharmSciTech, v. 6, n. 1, p. 101-107, 2005.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centro de Ensino Unificado do Distrito Federal
Brasil
Coordenação do Curso de Odontologia
UDF
publisher.none.fl_str_mv Centro de Ensino Unificado do Distrito Federal
Brasil
Coordenação do Curso de Odontologia
UDF
dc.source.none.fl_str_mv reponame:Repositório do Centro Universitário Braz Cubas
instname:Centro Universitário Braz Cubas (CUB)
instacron:CUB
instname_str Centro Universitário Braz Cubas (CUB)
instacron_str CUB
institution CUB
reponame_str Repositório do Centro Universitário Braz Cubas
collection Repositório do Centro Universitário Braz Cubas
repository.name.fl_str_mv Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)
repository.mail.fl_str_mv bibli@brazcubas.edu.br
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