A necrose hepática e renal induzida pelo uso indiscriminado de paracetamol (acetaminofeno)

• Autor(a) principal: Ribeiro, Giovana Ramos
• Data de Publicação: 2020
• Outros Autores: Pereira, Heloisa Fernandes, Bechara, Fabiana Moreira Nogueira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/1474
• topic: Paracetamol; Intoxicação; Falência hepática; Automedicação; CNPQ::CIENCIAS DA SAUDE::FARMACIA

Self-medication has an important influence in intoxication, considering that most of them occur among non-prescription drugs, prevailing the pharmaceutical class of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). Within this class, the drug with the highest incidence of self-medication and intoxication is paracetamol. In that context, the objective of the work was to address the practice of self-medication, especially paracetamol, and to relate its pharmacotherapeutic characteristics with the intoxications observed in the indiscriminate use of these drug through a bibliographic review with exploratory research in academic books, articles and scientific journals, in addition to the ToxBase®️ and IBM Micromedex®️ databases. Paracetamol entered into Brazilian pharmaceutical market in 1974, by the Janssen industry, being widely distributed in pharmacies and drugstores and dispensed as a non-prescription drug (NPD). Thus, its consumption the recommended doses in the literature, can trigger a serious intoxication by the formation of an extremely toxic metabolite (N-acetyl-p-benzoquinonaimine - NAPQI), leading to acute liver and kidney failure. Given the severity of the condition, the pharmacist is essential for guiding the community in behalf of self-medication and the correct and safe use of medicines, guaranteeing the patient's safety and quality of life.