Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017 |
Resumo: | Resumo: Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection. |
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Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidineMetabolic profileruminal pHabomasal pHsheepranitidinebiochemistry profileH2 antagonistshydrogen ion concentrationruminants.Resumo: Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection.Colégio Brasileiro de Patologia Animal - CBPA2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017Pesquisa Veterinária Brasileira v.34 suppl.1 2014reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2014001300004info:eu-repo/semantics/openAccessMorgado,Aline AlbertiNunes,Giovanna RochaMartins,André StortiHagen,Stefano Carlo FilippoRodrigues,Paulo Henrique MazzaSucupira,Maria Claudia Araripeeng2016-04-05T00:00:00Zoai:scielo:S0100-736X2014001300017Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2016-04-05T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
title |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
spellingShingle |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine Morgado,Aline Alberti Metabolic profile ruminal pH abomasal pH sheep ranitidine biochemistry profile H2 antagonists hydrogen ion concentration ruminants. |
title_short |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
title_full |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
title_fullStr |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
title_full_unstemmed |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
title_sort |
Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine |
author |
Morgado,Aline Alberti |
author_facet |
Morgado,Aline Alberti Nunes,Giovanna Rocha Martins,André Storti Hagen,Stefano Carlo Filippo Rodrigues,Paulo Henrique Mazza Sucupira,Maria Claudia Araripe |
author_role |
author |
author2 |
Nunes,Giovanna Rocha Martins,André Storti Hagen,Stefano Carlo Filippo Rodrigues,Paulo Henrique Mazza Sucupira,Maria Claudia Araripe |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Morgado,Aline Alberti Nunes,Giovanna Rocha Martins,André Storti Hagen,Stefano Carlo Filippo Rodrigues,Paulo Henrique Mazza Sucupira,Maria Claudia Araripe |
dc.subject.por.fl_str_mv |
Metabolic profile ruminal pH abomasal pH sheep ranitidine biochemistry profile H2 antagonists hydrogen ion concentration ruminants. |
topic |
Metabolic profile ruminal pH abomasal pH sheep ranitidine biochemistry profile H2 antagonists hydrogen ion concentration ruminants. |
description |
Resumo: Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2014001300004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.34 suppl.1 2014 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122234727759872 |