Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine

Detalhes bibliográficos
Autor(a) principal: Morgado,Aline Alberti
Data de Publicação: 2014
Outros Autores: Nunes,Giovanna Rocha, Martins,André Storti, Hagen,Stefano Carlo Filippo, Rodrigues,Paulo Henrique Mazza, Sucupira,Maria Claudia Araripe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017
Resumo: Resumo: Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection.
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spelling Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidineMetabolic profileruminal pHabomasal pHsheepranitidinebiochemistry profileH2 antagonistshydrogen ion concentrationruminants.Resumo: Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection.Colégio Brasileiro de Patologia Animal - CBPA2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017Pesquisa Veterinária Brasileira v.34 suppl.1 2014reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2014001300004info:eu-repo/semantics/openAccessMorgado,Aline AlbertiNunes,Giovanna RochaMartins,André StortiHagen,Stefano Carlo FilippoRodrigues,Paulo Henrique MazzaSucupira,Maria Claudia Araripeeng2016-04-05T00:00:00Zoai:scielo:S0100-736X2014001300017Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2016-04-05T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
title Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
spellingShingle Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
Morgado,Aline Alberti
Metabolic profile
ruminal pH
abomasal pH
sheep
ranitidine
biochemistry profile
H2 antagonists
hydrogen ion concentration
ruminants.
title_short Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
title_full Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
title_fullStr Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
title_full_unstemmed Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
title_sort Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine
author Morgado,Aline Alberti
author_facet Morgado,Aline Alberti
Nunes,Giovanna Rocha
Martins,André Storti
Hagen,Stefano Carlo Filippo
Rodrigues,Paulo Henrique Mazza
Sucupira,Maria Claudia Araripe
author_role author
author2 Nunes,Giovanna Rocha
Martins,André Storti
Hagen,Stefano Carlo Filippo
Rodrigues,Paulo Henrique Mazza
Sucupira,Maria Claudia Araripe
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Morgado,Aline Alberti
Nunes,Giovanna Rocha
Martins,André Storti
Hagen,Stefano Carlo Filippo
Rodrigues,Paulo Henrique Mazza
Sucupira,Maria Claudia Araripe
dc.subject.por.fl_str_mv Metabolic profile
ruminal pH
abomasal pH
sheep
ranitidine
biochemistry profile
H2 antagonists
hydrogen ion concentration
ruminants.
topic Metabolic profile
ruminal pH
abomasal pH
sheep
ranitidine
biochemistry profile
H2 antagonists
hydrogen ion concentration
ruminants.
description Resumo: Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001300017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-736X2014001300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.34 suppl.1 2014
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
instacron:EMBRAPA
instname_str Colégio Brasileiro de Patologia Animal (CBPA)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Pesquisa Veterinária Brasileira (Online)
collection Pesquisa Veterinária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)
repository.mail.fl_str_mv colegio@cbpa.org.br||pvb@pvb.com.br
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