Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | MedNEXT Journal of Medical and Health Sciences |
Texto Completo: | https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/280 |
Resumo: | Introduction: Polymethylmethacrylate (PMMA) is a synthetic, inert, biocompatible and nontoxic polymer, the applications in the medical field are numerous, and indications are increasingly broad. Objectives: To evaluate whether the fibrous response to injection of PMMA microspheres into striated muscles confers increased volume and resistance to muscle stretch. Methods: A total of 20 Wistar rats were injected with, 30% PMMA gel into the right rectus abdominis muscle, while the left rectus muscle received SHAM injections. After 4 weeks, all abdominal rectus muscles were measured and stretched on a bench dynamometer until rupture. The samples were analyzed histologically to verify the tissue response to PMMA. Results: The right rectus abdominis muscles of rats that received PMMA gel injection had increased volume and the breaking strength was greater than 100% compared to the left rectus muscles that received SHAM injections. There was a significant deposition of type I and III collagen fibers around the PMMA injection sites. Conclusion: PMMA microspheres implanted into the rectus abdominis muscle of Wistar rats promote neocollagenesis and significantly increase the breaking strength when subjected to stretch test. The mild and desired foreign body type tissue reaction around the PMMA is not objection to the augmentation of the rectus abdominis muscle. |
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Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental modelPolymethylmethacrylatePMMAAbdominal muscleRectus abdominisMuscle augmentationMuscle strengthNeocollagenesisRatsIntroduction: Polymethylmethacrylate (PMMA) is a synthetic, inert, biocompatible and nontoxic polymer, the applications in the medical field are numerous, and indications are increasingly broad. Objectives: To evaluate whether the fibrous response to injection of PMMA microspheres into striated muscles confers increased volume and resistance to muscle stretch. Methods: A total of 20 Wistar rats were injected with, 30% PMMA gel into the right rectus abdominis muscle, while the left rectus muscle received SHAM injections. After 4 weeks, all abdominal rectus muscles were measured and stretched on a bench dynamometer until rupture. The samples were analyzed histologically to verify the tissue response to PMMA. Results: The right rectus abdominis muscles of rats that received PMMA gel injection had increased volume and the breaking strength was greater than 100% compared to the left rectus muscles that received SHAM injections. There was a significant deposition of type I and III collagen fibers around the PMMA injection sites. Conclusion: PMMA microspheres implanted into the rectus abdominis muscle of Wistar rats promote neocollagenesis and significantly increase the breaking strength when subjected to stretch test. The mild and desired foreign body type tissue reaction around the PMMA is not objection to the augmentation of the rectus abdominis muscle.Faceres2023-05-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticleapplication/pdfhttps://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/28010.54448/mdnt23209MedNEXT Journal of Medical and Health Sciences; Vol. 4 No. 2 (2023): MedNEXT - March 2023MedNEXT Journal of Medical and Health Sciences; v. 4 n. 2 (2023): MedNEXT - March 20232763-567810.54448/10.54448/mdnt232reponame:MedNEXT Journal of Medical and Health Sciencesinstname:Faculdade de Medicina em São José do Rio Preto (Faceres)instacron:FACERESenghttps://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/280/264Copyright (c) 2023 Fernanda Bortolozo, Paulo César Alves Azizi, Eduardo Costa Teixeira, Mariana Rinaldi, Ângela Schütz Paschoal, Honório Sampaio Menezes, Priscila Souza, Gottfried Lemperlehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBortolozo, FernandaAzizi, Paulo César AlvesTeixeira, Eduardo CostaRinaldi, MarianaPaschoal, Ângela SchützMenezes, Honório SampaioSouza, PriscilaLemperle, Gottfried2023-05-03T16:46:00Zoai:ojs2.mednext.zotarellifilhoscientificworks.com:article/280Revistahttps://mednext.zotarellifilhoscientificworks.com/index.php/mednextPUBhttps://mednext.zotarellifilhoscientificworks.com/index.php/mednext/oaimednextjmhs@zotarellifilhoscientificworks.com2763-56782763-5678opendoar:2023-05-03T16:46MedNEXT Journal of Medical and Health Sciences - Faculdade de Medicina em São José do Rio Preto (Faceres)false |
dc.title.none.fl_str_mv |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
title |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
spellingShingle |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model Bortolozo, Fernanda Polymethylmethacrylate PMMA Abdominal muscle Rectus abdominis Muscle augmentation Muscle strength Neocollagenesis Rats |
title_short |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
title_full |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
title_fullStr |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
title_full_unstemmed |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
title_sort |
Polymethylmethacrylate injections for augmentation and strengthening of abdominal muscles: an experimental model |
author |
Bortolozo, Fernanda |
author_facet |
Bortolozo, Fernanda Azizi, Paulo César Alves Teixeira, Eduardo Costa Rinaldi, Mariana Paschoal, Ângela Schütz Menezes, Honório Sampaio Souza, Priscila Lemperle, Gottfried |
author_role |
author |
author2 |
Azizi, Paulo César Alves Teixeira, Eduardo Costa Rinaldi, Mariana Paschoal, Ângela Schütz Menezes, Honório Sampaio Souza, Priscila Lemperle, Gottfried |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Bortolozo, Fernanda Azizi, Paulo César Alves Teixeira, Eduardo Costa Rinaldi, Mariana Paschoal, Ângela Schütz Menezes, Honório Sampaio Souza, Priscila Lemperle, Gottfried |
dc.subject.por.fl_str_mv |
Polymethylmethacrylate PMMA Abdominal muscle Rectus abdominis Muscle augmentation Muscle strength Neocollagenesis Rats |
topic |
Polymethylmethacrylate PMMA Abdominal muscle Rectus abdominis Muscle augmentation Muscle strength Neocollagenesis Rats |
description |
Introduction: Polymethylmethacrylate (PMMA) is a synthetic, inert, biocompatible and nontoxic polymer, the applications in the medical field are numerous, and indications are increasingly broad. Objectives: To evaluate whether the fibrous response to injection of PMMA microspheres into striated muscles confers increased volume and resistance to muscle stretch. Methods: A total of 20 Wistar rats were injected with, 30% PMMA gel into the right rectus abdominis muscle, while the left rectus muscle received SHAM injections. After 4 weeks, all abdominal rectus muscles were measured and stretched on a bench dynamometer until rupture. The samples were analyzed histologically to verify the tissue response to PMMA. Results: The right rectus abdominis muscles of rats that received PMMA gel injection had increased volume and the breaking strength was greater than 100% compared to the left rectus muscles that received SHAM injections. There was a significant deposition of type I and III collagen fibers around the PMMA injection sites. Conclusion: PMMA microspheres implanted into the rectus abdominis muscle of Wistar rats promote neocollagenesis and significantly increase the breaking strength when subjected to stretch test. The mild and desired foreign body type tissue reaction around the PMMA is not objection to the augmentation of the rectus abdominis muscle. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/280 10.54448/mdnt23209 |
url |
https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/280 |
identifier_str_mv |
10.54448/mdnt23209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/280/264 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Faceres |
publisher.none.fl_str_mv |
Faceres |
dc.source.none.fl_str_mv |
MedNEXT Journal of Medical and Health Sciences; Vol. 4 No. 2 (2023): MedNEXT - March 2023 MedNEXT Journal of Medical and Health Sciences; v. 4 n. 2 (2023): MedNEXT - March 2023 2763-5678 10.54448/10.54448/mdnt232 reponame:MedNEXT Journal of Medical and Health Sciences instname:Faculdade de Medicina em São José do Rio Preto (Faceres) instacron:FACERES |
instname_str |
Faculdade de Medicina em São José do Rio Preto (Faceres) |
instacron_str |
FACERES |
institution |
FACERES |
reponame_str |
MedNEXT Journal of Medical and Health Sciences |
collection |
MedNEXT Journal of Medical and Health Sciences |
repository.name.fl_str_mv |
MedNEXT Journal of Medical and Health Sciences - Faculdade de Medicina em São José do Rio Preto (Faceres) |
repository.mail.fl_str_mv |
mednextjmhs@zotarellifilhoscientificworks.com |
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