Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia

Detalhes bibliográficos
Autor(a) principal: Sandrim,Valeria Cristina
Data de Publicação: 2020
Outros Autores: Luizon,Marcelo Rizzatti, Pilan,Eliane, Caldeira-Dias,Mayara, Coeli-Lacchini,Fernanda Borchers, Kors,Georgia, Berndt,Iuly, Lacchini,Riccardo, Cavalli,Ricardo Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de ginecologia e obstetrícia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020000800460
Resumo: Abstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA). Results We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness tomethyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA. Conclusion We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.
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spelling Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsiapreeclampsiapolymorphismantioxidantnitric oxideAbstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA). Results We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness tomethyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA. Conclusion We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.Federação Brasileira das Sociedades de Ginecologia e Obstetrícia2020-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020000800460Revista Brasileira de Ginecologia e Obstetrícia v.42 n.8 2020reponame:Revista brasileira de ginecologia e obstetrícia (Online)instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)instacron:FEBRASGO10.1055/s-0040-1712484info:eu-repo/semantics/openAccessSandrim,Valeria CristinaLuizon,Marcelo RizzattiPilan,ElianeCaldeira-Dias,MayaraCoeli-Lacchini,Fernanda BorchersKors,GeorgiaBerndt,IulyLacchini,RiccardoCavalli,Ricardo Carvalhoeng2020-09-22T00:00:00Zoai:scielo:S0100-72032020000800460Revistahttp://www.scielo.br/rbgohttps://old.scielo.br/oai/scielo-oai.phppublicações@febrasgo.org.br||rbgo@fmrp.usp.br1806-93390100-7203opendoar:2020-09-22T00:00Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)false
dc.title.none.fl_str_mv Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
title Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
spellingShingle Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
Sandrim,Valeria Cristina
preeclampsia
polymorphism
antioxidant
nitric oxide
title_short Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
title_full Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
title_fullStr Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
title_full_unstemmed Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
title_sort Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
author Sandrim,Valeria Cristina
author_facet Sandrim,Valeria Cristina
Luizon,Marcelo Rizzatti
Pilan,Eliane
Caldeira-Dias,Mayara
Coeli-Lacchini,Fernanda Borchers
Kors,Georgia
Berndt,Iuly
Lacchini,Riccardo
Cavalli,Ricardo Carvalho
author_role author
author2 Luizon,Marcelo Rizzatti
Pilan,Eliane
Caldeira-Dias,Mayara
Coeli-Lacchini,Fernanda Borchers
Kors,Georgia
Berndt,Iuly
Lacchini,Riccardo
Cavalli,Ricardo Carvalho
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sandrim,Valeria Cristina
Luizon,Marcelo Rizzatti
Pilan,Eliane
Caldeira-Dias,Mayara
Coeli-Lacchini,Fernanda Borchers
Kors,Georgia
Berndt,Iuly
Lacchini,Riccardo
Cavalli,Ricardo Carvalho
dc.subject.por.fl_str_mv preeclampsia
polymorphism
antioxidant
nitric oxide
topic preeclampsia
polymorphism
antioxidant
nitric oxide
description Abstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA). Results We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness tomethyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA. Conclusion We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020000800460
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020000800460
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1055/s-0040-1712484
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
publisher.none.fl_str_mv Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
dc.source.none.fl_str_mv Revista Brasileira de Ginecologia e Obstetrícia v.42 n.8 2020
reponame:Revista brasileira de ginecologia e obstetrícia (Online)
instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)
instacron:FEBRASGO
instname_str Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)
instacron_str FEBRASGO
institution FEBRASGO
reponame_str Revista brasileira de ginecologia e obstetrícia (Online)
collection Revista brasileira de ginecologia e obstetrícia (Online)
repository.name.fl_str_mv Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)
repository.mail.fl_str_mv publicações@febrasgo.org.br||rbgo@fmrp.usp.br
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