Potential therapeutic effect of Moringa oleifera Lamarck (Moringaceae) leaves: a revision of its role in glycemic control in vivo studies

• Autor(a) principal: Castro, Francker Duarte de
• Data de Publicação: 2022
• Outros Autores: Silva, Larissa Marina Pereira, Oliveira, Renata Borges de, Zucolotto, Silvana Maria
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1315
• topic: Moringa; Toxicidade; Antioxidante; Anti-hiperglicêmica; Diabetes; Moringa; Toxicity; Antioxidant; Antihyperglycemic; Diabetes

Moringa oleifera Lamarck (Moringaceae) has been highlighted in Brazil due to its high nutritional content and is widely used in food supplementation. Lately, many studies have been published about its actions in the treatment of diabetes mellitus and in several other properties, such as antioxidant, tissue protector and antihypertensive and immunomodulator effect. However, its growing irrational use by the population has triggered the prohibition of its use and commercialization of products in Brazil by the National Health Surveillance Agency (ANVISA). In this context, this study aimed to conduct a literature review to assess the potential antidiabetic action of M. oleifera leaves. For this purpose, 43 non-clinical studies (12 - in vitro; 31 - in vivo) were analyzed. The studies analyzed pointed to a promising antidiabetic activity. However, the lack of methodological standardization of the process and chemical characterization of products added to some methodological biases in studies weakened the scientific evidence on their efficacy, and the understanding of their mechanism of action.