Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease

Detalhes bibliográficos
Autor(a) principal: Moraes , Poliana Zanoni de
Data de Publicação: 2022
Outros Autores: Fukushima, André Rinaldi, Nicoletti, Maria Aparecida
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255
Resumo: Considering the limited therapeutic effects of current medications for trying to treat or reduce the symptoms of Alzheimer's disease, it is relevant to search for new therapeutic alternatives, with significant efficacy and reduced side effects. One of the promising solutions to prevent the progression of behavioral and cognitive changes in the disease are cannabinoid derivatives, in which in vivo studies have shown a reduction in oxidative stress, neuroinflammation, formation of amyloid plaques and neurofibrillary tangles, in addition being related to regulation activation of microglial cells and release of macromolecules, all factors that, when present, contribute to the worsening and evolution of the disease. Medicinal Cannabis and cannabinoid derivatives such as cannabidiol and Δ9-tetrahydrocannabinol have shown very significant therapeutic efficacy for various diseases and symptoms, such as chronic pain, nausea and vomiting induced by chemotherapy, multiple sclerosis, anorexia nervosa, anxiety, Huntington's disease, Parkinson's disease, epilepsy, Alzheimer's disease, among others. Therefore, this work aimed to gather studies that would enable the analysis of the efficacy/effectiveness of cannabinoid derivatives in Alzheimer's disease in more updated publications.
id FIOCRUZ-1_ff31f83827e2cfe6dfd81a861565030e
oai_identifier_str oai:ojs.revistafitos.far.fiocruz.br:article/1255
network_acronym_str FIOCRUZ-1
network_name_str Revista Fitos
repository_id_str
spelling Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s diseaseVerificación de la eficacia / eficacia del cannabis medicinal y los derivados de cannabinoides en la enfermedad de AlzheimerRevisão integrativa: verificação da eficácia / efetividade da Cannabis medicinal e dos derivados canabinoides na Doença de AlzheimerDoença de AlzheimerCanabinoideCannabis sativaDemênciaAlzheimer diseaseCannabinoidsCannabis sativaDementiaConsidering the limited therapeutic effects of current medications for trying to treat or reduce the symptoms of Alzheimer's disease, it is relevant to search for new therapeutic alternatives, with significant efficacy and reduced side effects. One of the promising solutions to prevent the progression of behavioral and cognitive changes in the disease are cannabinoid derivatives, in which in vivo studies have shown a reduction in oxidative stress, neuroinflammation, formation of amyloid plaques and neurofibrillary tangles, in addition being related to regulation activation of microglial cells and release of macromolecules, all factors that, when present, contribute to the worsening and evolution of the disease. Medicinal Cannabis and cannabinoid derivatives such as cannabidiol and Δ9-tetrahydrocannabinol have shown very significant therapeutic efficacy for various diseases and symptoms, such as chronic pain, nausea and vomiting induced by chemotherapy, multiple sclerosis, anorexia nervosa, anxiety, Huntington's disease, Parkinson's disease, epilepsy, Alzheimer's disease, among others. Therefore, this work aimed to gather studies that would enable the analysis of the efficacy/effectiveness of cannabinoid derivatives in Alzheimer's disease in more updated publications.Considerando los limitados efectos terapéuticos de los medicamentos actuales para tratar o reducir los síntomas de la enfermedad de Alzheimer, es relevante buscar nuevas alternativas terapéuticas, con una eficacia significativa y efectos secundarios reducidos. Una de las soluciones prometedoras para prevenir la progresión de cambios conductuales y cognitivos en la enfermedad son los derivados cannabinoides, en los que estudios in vivo han demostrado una reducción del estrés oxidativo, neuroinflamación, formación de placas amiloides y ovillos neurofibrilares, además de estar relacionados con regulación de la activación de las células microgliales y liberación de macromoléculas, factores todos que, cuando están presentes, contribuyen al agravamiento y evolución de la enfermedad. El cannabis medicinal y los derivados cannabinoides como el cannabidiol y el Δ9-tetrahidrocannabinol han demostrado una eficacia terapéutica muy significativa para diversas enfermedades y síntomas, como dolor crónico, náuseas y vómitos inducidos por quimioterapia, esclerosis múltiple, anorexia nerviosa, ansiedad, enfermedad de Huntington, enfermedad de Parkinson, epilepsia, enfermedad de Alzheimer, entre otras. Por tanto, este trabajo tuvo como objetivo recopilar estudios que permitieran analizar la eficacia / efectividad de los derivados cannabinoides en la enfermedad de Alzheimer en publicaciones más actualizadas.   Considerando os efeitos terapêuticos limitados das medicações atuais para a tentativa de tratamento ou diminuição dos sintomas da doença de Alzheimer, torna-se relevante a busca por novas alternativas terapêuticas, com eficácia significativa e efeitos colaterais diminuídos. Uma das soluções promissoras para impedir a progressão das alterações comportamentais e cognitivas da doença são os derivados canabinoides, nos quais estudos in vivo têm mostrado uma redução no estresse oxidativo, neuroinflamação, formação de placas amiloides e emaranhados neurofibrilares, além de estar relacionado com a regulação da ativação das células da microglia e liberação de macromoléculas, todos os fatores que quando presentes, contribuem para a piora e evolução da doença. A Cannabis medicinal e os derivados canabinoides como o canabidiol e o Δ9-tetraidrocanabinol têm mostrado eficácia terapêutica bastante significativa para variadas doenças e sintomas, como dor crônica, náusea e vômito induzidos pela quimioterapia, esclerose múltipla, anorexia nervosa, ansiedade, doença de Huntington, doença de Parkinson, epilepsia, doença de Alzheimer, entre outros. Sendo assim, esse trabalho teve como objetivo reunir estudos que possibilitassem a análise da eficácia/efetividade dos derivados canabinoides na doença de Alzheimer em publicações mais atualizadas.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2022-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/125510.32712/2446-4775.2022.1255Revista Fitos; Vol. 16 No. 1 (2022); 120-141Revista Fitos; Vol. 16 Núm. 1 (2022); 120-141Revista Fitos; v. 16 n. 1 (2022); 120-1412446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255/1044https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255/1045Copyright (c) 2022 Revista Fitosinfo:eu-repo/semantics/openAccessMoraes , Poliana Zanoni deFukushima, André RinaldiNicoletti, Maria Aparecida2022-03-31T20:54:38Zoai:ojs.revistafitos.far.fiocruz.br:article/1255Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-03-31T20:54:38Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
Verificación de la eficacia / eficacia del cannabis medicinal y los derivados de cannabinoides en la enfermedad de Alzheimer
Revisão integrativa: verificação da eficácia / efetividade da Cannabis medicinal e dos derivados canabinoides na Doença de Alzheimer
title Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
spellingShingle Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
Moraes , Poliana Zanoni de
Doença de Alzheimer
Canabinoide
Cannabis sativa
Demência
Alzheimer disease
Cannabinoids
Cannabis sativa
Dementia
title_short Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
title_full Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
title_fullStr Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
title_full_unstemmed Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
title_sort Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
author Moraes , Poliana Zanoni de
author_facet Moraes , Poliana Zanoni de
Fukushima, André Rinaldi
Nicoletti, Maria Aparecida
author_role author
author2 Fukushima, André Rinaldi
Nicoletti, Maria Aparecida
author2_role author
author
dc.contributor.author.fl_str_mv Moraes , Poliana Zanoni de
Fukushima, André Rinaldi
Nicoletti, Maria Aparecida
dc.subject.por.fl_str_mv Doença de Alzheimer
Canabinoide
Cannabis sativa
Demência
Alzheimer disease
Cannabinoids
Cannabis sativa
Dementia
topic Doença de Alzheimer
Canabinoide
Cannabis sativa
Demência
Alzheimer disease
Cannabinoids
Cannabis sativa
Dementia
description Considering the limited therapeutic effects of current medications for trying to treat or reduce the symptoms of Alzheimer's disease, it is relevant to search for new therapeutic alternatives, with significant efficacy and reduced side effects. One of the promising solutions to prevent the progression of behavioral and cognitive changes in the disease are cannabinoid derivatives, in which in vivo studies have shown a reduction in oxidative stress, neuroinflammation, formation of amyloid plaques and neurofibrillary tangles, in addition being related to regulation activation of microglial cells and release of macromolecules, all factors that, when present, contribute to the worsening and evolution of the disease. Medicinal Cannabis and cannabinoid derivatives such as cannabidiol and Δ9-tetrahydrocannabinol have shown very significant therapeutic efficacy for various diseases and symptoms, such as chronic pain, nausea and vomiting induced by chemotherapy, multiple sclerosis, anorexia nervosa, anxiety, Huntington's disease, Parkinson's disease, epilepsy, Alzheimer's disease, among others. Therefore, this work aimed to gather studies that would enable the analysis of the efficacy/effectiveness of cannabinoid derivatives in Alzheimer's disease in more updated publications.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255
10.32712/2446-4775.2022.1255
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255
identifier_str_mv 10.32712/2446-4775.2022.1255
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255/1044
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255/1045
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Fitos
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Fitos
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 16 No. 1 (2022); 120-141
Revista Fitos; Vol. 16 Núm. 1 (2022); 120-141
Revista Fitos; v. 16 n. 1 (2022); 120-141
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
_version_ 1798313475984850944

Registros relacionados