Dengue 2 virus enhancement in asthmatic and non asthmatic individual

Detalhes bibliográficos
Autor(a) principal: Guzman,Maria G.
Data de Publicação: 1992
Outros Autores: Kouri,Gustavo, Soler,Maritza, Bravo,Jose, Vega,Adolfo Rodriguez de la, Vazquez,Susana, Mune,Mayra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000400016
Resumo: During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorragic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X² p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.
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spelling Dengue 2 virus enhancement in asthmatic and non asthmatic individualdenguemacrophagesantibody dependentenhancementDuring the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorragic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X² p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.Instituto Oswaldo Cruz, Ministério da Saúde1992-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000400016Memórias do Instituto Oswaldo Cruz v.87 n.4 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000400016info:eu-repo/semantics/openAccessGuzman,Maria G.Kouri,GustavoSoler,MaritzaBravo,JoseVega,Adolfo Rodriguez de laVazquez,SusanaMune,Mayraeng2020-04-25T17:46:53Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:04:47.942Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Dengue 2 virus enhancement in asthmatic and non asthmatic individual
title Dengue 2 virus enhancement in asthmatic and non asthmatic individual
spellingShingle Dengue 2 virus enhancement in asthmatic and non asthmatic individual
Guzman,Maria G.
dengue
macrophages
antibody dependent
enhancement
title_short Dengue 2 virus enhancement in asthmatic and non asthmatic individual
title_full Dengue 2 virus enhancement in asthmatic and non asthmatic individual
title_fullStr Dengue 2 virus enhancement in asthmatic and non asthmatic individual
title_full_unstemmed Dengue 2 virus enhancement in asthmatic and non asthmatic individual
title_sort Dengue 2 virus enhancement in asthmatic and non asthmatic individual
author Guzman,Maria G.
author_facet Guzman,Maria G.
Kouri,Gustavo
Soler,Maritza
Bravo,Jose
Vega,Adolfo Rodriguez de la
Vazquez,Susana
Mune,Mayra
author_role author
author2 Kouri,Gustavo
Soler,Maritza
Bravo,Jose
Vega,Adolfo Rodriguez de la
Vazquez,Susana
Mune,Mayra
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guzman,Maria G.
Kouri,Gustavo
Soler,Maritza
Bravo,Jose
Vega,Adolfo Rodriguez de la
Vazquez,Susana
Mune,Mayra
dc.subject.por.fl_str_mv dengue
macrophages
antibody dependent
enhancement
topic dengue
macrophages
antibody dependent
enhancement
dc.description.none.fl_txt_mv During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorragic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X² p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.
description During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorragic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X² p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.
publishDate 1992
dc.date.none.fl_str_mv 1992-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000400016
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000400016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761992000400016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.87 n.4 1992
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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