Dengue virus–specific antibodies enhance brazilian Zika vrus infection
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1093/infdis/jiw638 http://www.locus.ufv.br/handle/123456789/14857 |
Resumo: | Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections. |
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Castanha, Priscila M. S.Nascimento, Eduardo J. M.Braga, CynthiaCordeiro, Marli T.Carvalho, Otávio V. deMendonça, Leila R. deAzevedo, Elisa A. N.França, Rafael F. O.Dhalia, RafaelMarques, Ernesto T. A.2017-12-12T17:07:05Z2017-12-12T17:07:05Z2016-12-301537-6613https://doi.org/10.1093/infdis/jiw638http://www.locus.ufv.br/handle/123456789/14857Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.engThe Journal of Infectious Diseases215(5), p. 781-785, Mar. 2017Zika virusAntibody dependent enhancementDengue antibodiesDengue virus–specific antibodies enhance brazilian Zika vrus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALdocument.pdfdocument.pdftexto completoapplication/pdf410598https://locus.ufv.br//bitstream/123456789/14857/1/document.pdfde63aa9bb58ae0d2e36a75b20881cad6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/14857/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILdocument.pdf.jpgdocument.pdf.jpgIM Thumbnailimage/jpeg4778https://locus.ufv.br//bitstream/123456789/14857/3/document.pdf.jpg850ec8b3afa936b6eb78d7137593cc68MD53123456789/148572017-12-12 22:00:58.278oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452017-12-13T01:00:58LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
title |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
spellingShingle |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection Castanha, Priscila M. S. Zika virus Antibody dependent enhancement Dengue antibodies |
title_short |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
title_full |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
title_fullStr |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
title_full_unstemmed |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
title_sort |
Dengue virus–specific antibodies enhance brazilian Zika vrus infection |
author |
Castanha, Priscila M. S. |
author_facet |
Castanha, Priscila M. S. Nascimento, Eduardo J. M. Braga, Cynthia Cordeiro, Marli T. Carvalho, Otávio V. de Mendonça, Leila R. de Azevedo, Elisa A. N. França, Rafael F. O. Dhalia, Rafael Marques, Ernesto T. A. |
author_role |
author |
author2 |
Nascimento, Eduardo J. M. Braga, Cynthia Cordeiro, Marli T. Carvalho, Otávio V. de Mendonça, Leila R. de Azevedo, Elisa A. N. França, Rafael F. O. Dhalia, Rafael Marques, Ernesto T. A. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Castanha, Priscila M. S. Nascimento, Eduardo J. M. Braga, Cynthia Cordeiro, Marli T. Carvalho, Otávio V. de Mendonça, Leila R. de Azevedo, Elisa A. N. França, Rafael F. O. Dhalia, Rafael Marques, Ernesto T. A. |
dc.subject.pt-BR.fl_str_mv |
Zika virus Antibody dependent enhancement Dengue antibodies |
topic |
Zika virus Antibody dependent enhancement Dengue antibodies |
description |
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-12-30 |
dc.date.accessioned.fl_str_mv |
2017-12-12T17:07:05Z |
dc.date.available.fl_str_mv |
2017-12-12T17:07:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1093/infdis/jiw638 http://www.locus.ufv.br/handle/123456789/14857 |
dc.identifier.issn.none.fl_str_mv |
1537-6613 |
identifier_str_mv |
1537-6613 |
url |
https://doi.org/10.1093/infdis/jiw638 http://www.locus.ufv.br/handle/123456789/14857 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
215(5), p. 781-785, Mar. 2017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
The Journal of Infectious Diseases |
publisher.none.fl_str_mv |
The Journal of Infectious Diseases |
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LOCUS Repositório Institucional da UFV |
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