Dengue virus–specific antibodies enhance brazilian Zika virus infection

Detalhes bibliográficos
Autor(a) principal: Castanha, Priscila M. S.
Data de Publicação: 2016
Outros Autores: Nascimento, Eduardo J. M., Braga, Cynthia, Cordeiro, Marli T., Carvalho, Otávio V. de, Mendonça, Leila R. de, Azevedo, Elisa A. N., França, Rafael F. O., Dhalia, Rafael, Marques, Ernesto T. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: https://doi.org/10.1093/infdis/jiw638
http://www.locus.ufv.br/handle/123456789/18740
Resumo: Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We ­demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
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spelling Castanha, Priscila M. S.Nascimento, Eduardo J. M.Braga, CynthiaCordeiro, Marli T.Carvalho, Otávio V. deMendonça, Leila R. deAzevedo, Elisa A. N.França, Rafael F. O.Dhalia, RafaelMarques, Ernesto T. A.2018-04-16T18:09:52Z2018-04-16T18:09:52Z2016-12-3015376613https://doi.org/10.1093/infdis/jiw638http://www.locus.ufv.br/handle/123456789/18740Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We ­demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.engThe Journal of Infectious Diseasesv. 215, Issue 5, p. 781–785, March 2017Zika virusAntibody dependent enhancementDengue antibodiesDengue virus–specific antibodies enhance brazilian Zika virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdfTexto completoapplication/pdf410392https://locus.ufv.br//bitstream/123456789/18740/1/artigo.pdfad5ce68249008047ce2ef3f4d25a5a93MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/18740/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg4768https://locus.ufv.br//bitstream/123456789/18740/3/artigo.pdf.jpg5f28ff2e1f7d741530eb45296cc88e69MD53123456789/187402018-04-16 23:00:49.63oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-04-17T02:00:49LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv Dengue virus–specific antibodies enhance brazilian Zika virus infection
title Dengue virus–specific antibodies enhance brazilian Zika virus infection
spellingShingle Dengue virus–specific antibodies enhance brazilian Zika virus infection
Castanha, Priscila M. S.
Zika virus
Antibody dependent enhancement
Dengue antibodies
title_short Dengue virus–specific antibodies enhance brazilian Zika virus infection
title_full Dengue virus–specific antibodies enhance brazilian Zika virus infection
title_fullStr Dengue virus–specific antibodies enhance brazilian Zika virus infection
title_full_unstemmed Dengue virus–specific antibodies enhance brazilian Zika virus infection
title_sort Dengue virus–specific antibodies enhance brazilian Zika virus infection
author Castanha, Priscila M. S.
author_facet Castanha, Priscila M. S.
Nascimento, Eduardo J. M.
Braga, Cynthia
Cordeiro, Marli T.
Carvalho, Otávio V. de
Mendonça, Leila R. de
Azevedo, Elisa A. N.
França, Rafael F. O.
Dhalia, Rafael
Marques, Ernesto T. A.
author_role author
author2 Nascimento, Eduardo J. M.
Braga, Cynthia
Cordeiro, Marli T.
Carvalho, Otávio V. de
Mendonça, Leila R. de
Azevedo, Elisa A. N.
França, Rafael F. O.
Dhalia, Rafael
Marques, Ernesto T. A.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castanha, Priscila M. S.
Nascimento, Eduardo J. M.
Braga, Cynthia
Cordeiro, Marli T.
Carvalho, Otávio V. de
Mendonça, Leila R. de
Azevedo, Elisa A. N.
França, Rafael F. O.
Dhalia, Rafael
Marques, Ernesto T. A.
dc.subject.pt-BR.fl_str_mv Zika virus
Antibody dependent enhancement
Dengue antibodies
topic Zika virus
Antibody dependent enhancement
Dengue antibodies
description Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We ­demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
publishDate 2016
dc.date.issued.fl_str_mv 2016-12-30
dc.date.accessioned.fl_str_mv 2018-04-16T18:09:52Z
dc.date.available.fl_str_mv 2018-04-16T18:09:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1093/infdis/jiw638
http://www.locus.ufv.br/handle/123456789/18740
dc.identifier.issn.none.fl_str_mv 15376613
identifier_str_mv 15376613
url https://doi.org/10.1093/infdis/jiw638
http://www.locus.ufv.br/handle/123456789/18740
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv v. 215, Issue 5, p. 781–785, March 2017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv The Journal of Infectious Diseases
publisher.none.fl_str_mv The Journal of Infectious Diseases
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
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reponame_str LOCUS Repositório Institucional da UFV
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