Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Detalhes bibliográficos
Autor(a) principal: Kaneshima,Edilson N
Data de Publicação: 2005
Outros Autores: Castro-Prado,Marialba A Alves de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020
Resumo: Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
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spelling Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulansbenznidazolesomatic recombinationgenotoxicityhomozigotization indexGenotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.Instituto Oswaldo Cruz, Ministério da Saúde2005-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020Memórias do Instituto Oswaldo Cruz v.100 n.3 2005reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762005000300020info:eu-repo/semantics/openAccessKaneshima,Edilson NCastro-Prado,Marialba A Alves deeng2020-04-25T17:49:24Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:09.378Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
title Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
spellingShingle Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
Kaneshima,Edilson N
benznidazole
somatic recombination
genotoxicity
homozigotization index
title_short Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
title_full Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
title_fullStr Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
title_full_unstemmed Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
title_sort Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
author Kaneshima,Edilson N
author_facet Kaneshima,Edilson N
Castro-Prado,Marialba A Alves de
author_role author
author2 Castro-Prado,Marialba A Alves de
author2_role author
dc.contributor.author.fl_str_mv Kaneshima,Edilson N
Castro-Prado,Marialba A Alves de
dc.subject.por.fl_str_mv benznidazole
somatic recombination
genotoxicity
homozigotization index
topic benznidazole
somatic recombination
genotoxicity
homozigotization index
dc.description.none.fl_txt_mv Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
description Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
publishDate 2005
dc.date.none.fl_str_mv 2005-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762005000300020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.100 n.3 2005
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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