Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
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Data de Publicação: | 2005 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020 |
Resumo: | Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug. |
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Memórias do Instituto Oswaldo Cruz |
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Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulansbenznidazolesomatic recombinationgenotoxicityhomozigotization indexGenotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.Instituto Oswaldo Cruz, Ministério da Saúde2005-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020Memórias do Instituto Oswaldo Cruz v.100 n.3 2005reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762005000300020info:eu-repo/semantics/openAccessKaneshima,Edilson NCastro-Prado,Marialba A Alves deeng2020-04-25T17:49:24Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:09.378Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
title |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
spellingShingle |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans Kaneshima,Edilson N benznidazole somatic recombination genotoxicity homozigotization index |
title_short |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
title_full |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
title_fullStr |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
title_full_unstemmed |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
title_sort |
Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans |
author |
Kaneshima,Edilson N |
author_facet |
Kaneshima,Edilson N Castro-Prado,Marialba A Alves de |
author_role |
author |
author2 |
Castro-Prado,Marialba A Alves de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Kaneshima,Edilson N Castro-Prado,Marialba A Alves de |
dc.subject.por.fl_str_mv |
benznidazole somatic recombination genotoxicity homozigotization index |
topic |
benznidazole somatic recombination genotoxicity homozigotization index |
dc.description.none.fl_txt_mv |
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug. |
description |
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000300020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762005000300020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.100 n.3 2005 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937693216210944 |