Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil

Detalhes bibliográficos
Autor(a) principal: Andrade,Bruno Gabriel N
Data de Publicação: 2014
Outros Autores: Marin,Michel F Abanto, Cambuy,Diego Duque, Fonseca,Erica Lourenço, Souza,Nadjla Ferreira, Vicente,Ana Carolina P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700972
Resumo: There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.
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spelling Complete genome sequence of a clinical Bordetella pertussis isolate from BrazilptxP3pandemic lineagevirulence factorsantigenic variantThere has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.Instituto Oswaldo Cruz, Ministério da Saúde2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700972Memórias do Instituto Oswaldo Cruz v.109 n.7 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140288info:eu-repo/semantics/openAccessAndrade,Bruno Gabriel NMarin,Michel F AbantoCambuy,Diego DuqueFonseca,Erica LourençoSouza,Nadjla FerreiraVicente,Ana Carolina Peng2020-04-25T17:51:49Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:55.464Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
title Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
spellingShingle Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
Andrade,Bruno Gabriel N
ptxP3
pandemic lineage
virulence factors
antigenic variant
title_short Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
title_full Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
title_fullStr Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
title_full_unstemmed Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
title_sort Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil
author Andrade,Bruno Gabriel N
author_facet Andrade,Bruno Gabriel N
Marin,Michel F Abanto
Cambuy,Diego Duque
Fonseca,Erica Lourenço
Souza,Nadjla Ferreira
Vicente,Ana Carolina P
author_role author
author2 Marin,Michel F Abanto
Cambuy,Diego Duque
Fonseca,Erica Lourenço
Souza,Nadjla Ferreira
Vicente,Ana Carolina P
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade,Bruno Gabriel N
Marin,Michel F Abanto
Cambuy,Diego Duque
Fonseca,Erica Lourenço
Souza,Nadjla Ferreira
Vicente,Ana Carolina P
dc.subject.por.fl_str_mv ptxP3
pandemic lineage
virulence factors
antigenic variant
topic ptxP3
pandemic lineage
virulence factors
antigenic variant
dc.description.none.fl_txt_mv There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.
description There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700972
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700972
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276140288
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.7 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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