Evolution of the variant surface glycoprotein family in African trypanosomes

Detalhes bibliográficos
Autor(a) principal: Silva Pereira, Sara
Data de Publicação: 2022
Outros Autores: Jackson, Andrew P., Figueiredo, Luisa M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50689
Resumo: © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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spelling Evolution of the variant surface glycoprotein family in African trypanosomesAfrican trypanosomesAfrican trypanosomiasisAntigenic diversityAntigenic variationNaganaVariant surface glycoproteins© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies have revealed that the VSG repertoire has a complex evolutionary history. Sequence diversity, genomic organization, and expression patterns are species-specific, which may explain other variations in parasite virulence and disease pathology. Evidence also shows that we may be underestimating the extent to what VSGs are repurposed beyond their roles as variant antigens, establishing a need to examine VSG functionality more deeply. Here, we review sequence variation within the VSG gene family, and highlight the many opportunities to explore their likely diverse contributions to parasite survival.S.S.P. is funded by the European Union's Horizon 2020 research and innovation program through a Marie Skłodowska-Curie Individual Standard European Fellowship , under grant agreement no. 839960 . A.P.J. is funded by a Leverhulme Trust Research Fellowship ( RF-2020-413 ). L.M.F. is an Investigator CEEC of the Fundação para a Ciência e a Tecnologia ( CEECIND/03322/2018 ) and the laboratory is funded by the ERC (FatTryp, ref. 771714 ).ElsevierRepositório da Universidade de LisboaSilva Pereira, SaraJackson, Andrew P.Figueiredo, Luisa M.2022-01-04T14:07:54Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50689engTrends Parasitol. 2022 Jan;38(1):23-361471-492210.1016/j.pt.2021.07.0121471-5007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:54Zoai:repositorio.ul.pt:10451/50689Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:02.388348Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evolution of the variant surface glycoprotein family in African trypanosomes
title Evolution of the variant surface glycoprotein family in African trypanosomes
spellingShingle Evolution of the variant surface glycoprotein family in African trypanosomes
Silva Pereira, Sara
African trypanosomes
African trypanosomiasis
Antigenic diversity
Antigenic variation
Nagana
Variant surface glycoproteins
title_short Evolution of the variant surface glycoprotein family in African trypanosomes
title_full Evolution of the variant surface glycoprotein family in African trypanosomes
title_fullStr Evolution of the variant surface glycoprotein family in African trypanosomes
title_full_unstemmed Evolution of the variant surface glycoprotein family in African trypanosomes
title_sort Evolution of the variant surface glycoprotein family in African trypanosomes
author Silva Pereira, Sara
author_facet Silva Pereira, Sara
Jackson, Andrew P.
Figueiredo, Luisa M.
author_role author
author2 Jackson, Andrew P.
Figueiredo, Luisa M.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva Pereira, Sara
Jackson, Andrew P.
Figueiredo, Luisa M.
dc.subject.por.fl_str_mv African trypanosomes
African trypanosomiasis
Antigenic diversity
Antigenic variation
Nagana
Variant surface glycoproteins
topic African trypanosomes
African trypanosomiasis
Antigenic diversity
Antigenic variation
Nagana
Variant surface glycoproteins
description © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
publishDate 2022
dc.date.none.fl_str_mv 2022-01-04T14:07:54Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50689
url http://hdl.handle.net/10451/50689
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Trends Parasitol. 2022 Jan;38(1):23-36
1471-4922
10.1016/j.pt.2021.07.012
1471-5007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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