The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models

Detalhes bibliográficos
Autor(a) principal: Souza,Adriano LS
Data de Publicação: 2006
Outros Autores: Sousa-Pereira,Silvio R, Teixeira,Mauro M, Lambertucci,José R, Teixeira,Antonio L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900054
Resumo: Chemokines are a superfamily of low-molecular-weight cytokines that were initially described for their chemoattractant activity. It is now clear chemokines have several other activities that modulate immune processes. More than 50 chemokines ligands and at least 19 receptors have been described to date. Depending on the number of N-terminal cysteine residues, chemokines are grouped in the subfamilies CXC, CC, C or CX3C. A growing body of evidence suggests a role for chemokines in the pathogenesis of several inflammatory diseases. Our studies involving mice and humans infected with Schistosoma mansoni suggest an important role of the chemokine CCL3 and its receptors (CCR1 and CCR5) in the pathogenesis of severe schistosomiasis. We suggest that the differential activation of CCR1 or CCR5 during the course of schistosomiasis may dictate the outcome of the disease.
id FIOCRUZ-4_73b785954314582a75be4dadef1bd7bc
oai_identifier_str oai:scielo:S0074-02762006000900054
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine modelsschistosomiasischemokinesinflammationChemokines are a superfamily of low-molecular-weight cytokines that were initially described for their chemoattractant activity. It is now clear chemokines have several other activities that modulate immune processes. More than 50 chemokines ligands and at least 19 receptors have been described to date. Depending on the number of N-terminal cysteine residues, chemokines are grouped in the subfamilies CXC, CC, C or CX3C. A growing body of evidence suggests a role for chemokines in the pathogenesis of several inflammatory diseases. Our studies involving mice and humans infected with Schistosoma mansoni suggest an important role of the chemokine CCL3 and its receptors (CCR1 and CCR5) in the pathogenesis of severe schistosomiasis. We suggest that the differential activation of CCR1 or CCR5 during the course of schistosomiasis may dictate the outcome of the disease.Instituto Oswaldo Cruz, Ministério da Saúde2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900054Memórias do Instituto Oswaldo Cruz v.101 suppl.1 2006reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762006000900054info:eu-repo/semantics/openAccessSouza,Adriano LSSousa-Pereira,Silvio RTeixeira,Mauro MLambertucci,José RTeixeira,Antonio Leng2020-04-25T17:49:44Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:14:16.723Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
title The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
spellingShingle The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
Souza,Adriano LS
schistosomiasis
chemokines
inflammation
title_short The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
title_full The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
title_fullStr The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
title_full_unstemmed The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
title_sort The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
author Souza,Adriano LS
author_facet Souza,Adriano LS
Sousa-Pereira,Silvio R
Teixeira,Mauro M
Lambertucci,José R
Teixeira,Antonio L
author_role author
author2 Sousa-Pereira,Silvio R
Teixeira,Mauro M
Lambertucci,José R
Teixeira,Antonio L
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Souza,Adriano LS
Sousa-Pereira,Silvio R
Teixeira,Mauro M
Lambertucci,José R
Teixeira,Antonio L
dc.subject.por.fl_str_mv schistosomiasis
chemokines
inflammation
topic schistosomiasis
chemokines
inflammation
dc.description.none.fl_txt_mv Chemokines are a superfamily of low-molecular-weight cytokines that were initially described for their chemoattractant activity. It is now clear chemokines have several other activities that modulate immune processes. More than 50 chemokines ligands and at least 19 receptors have been described to date. Depending on the number of N-terminal cysteine residues, chemokines are grouped in the subfamilies CXC, CC, C or CX3C. A growing body of evidence suggests a role for chemokines in the pathogenesis of several inflammatory diseases. Our studies involving mice and humans infected with Schistosoma mansoni suggest an important role of the chemokine CCL3 and its receptors (CCR1 and CCR5) in the pathogenesis of severe schistosomiasis. We suggest that the differential activation of CCR1 or CCR5 during the course of schistosomiasis may dictate the outcome of the disease.
description Chemokines are a superfamily of low-molecular-weight cytokines that were initially described for their chemoattractant activity. It is now clear chemokines have several other activities that modulate immune processes. More than 50 chemokines ligands and at least 19 receptors have been described to date. Depending on the number of N-terminal cysteine residues, chemokines are grouped in the subfamilies CXC, CC, C or CX3C. A growing body of evidence suggests a role for chemokines in the pathogenesis of several inflammatory diseases. Our studies involving mice and humans infected with Schistosoma mansoni suggest an important role of the chemokine CCL3 and its receptors (CCR1 and CCR5) in the pathogenesis of severe schistosomiasis. We suggest that the differential activation of CCR1 or CCR5 during the course of schistosomiasis may dictate the outcome of the disease.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900054
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900054
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762006000900054
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.101 suppl.1 2006
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937698440216576

Registros relacionados