Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Campanelli, Ana Paula
Data de Publicação: 2010
Outros Autores: Brodskyn, Claudia Ida, Boaventura, Viviane Sampaio, Silva, Claire, Barral-Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12049
Resumo: Texto completo: acesso restrito. p.1220–1227
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spelling Campanelli, Ana PaulaBrodskyn, Claudia IdaBoaventura, Viviane SampaioSilva, ClaireBarral-Netto, ManoelBarral, Aldina Maria PradoCampanelli, Ana PaulaBrodskyn, Claudia IdaBoaventura, Viviane SampaioSilva, ClaireBarral-Netto, ManoelBarral, Aldina Maria Prado2013-06-27T21:02:35Z20100198-8859http://www.repositorio.ufba.br/ri/handle/ri/12049v. 71, n. 12Texto completo: acesso restrito. p.1220–1227Cutaneous leishmaniasis (CL) includes different clinical manifestations displaying diverse intensities of dermal inflammatory infiltrate. Diffuse CL (DCL) cases are hyporesponsive, and lesions show very few lymphocytes and a predominance of macrophages. In contrast, localized CL (LCL) cases are responsive to leishmanial antigen, and lesions exhibit granulocytes and mononuclear cell infiltration in the early phases, changing to a pattern with numerous lymphocytes and macrophages later in the lesion. Therefore, different chemokines may affect the predominance of cell infiltration in distinct clinical manifestations. In lesions from LCL patients, we examined by flow cytometry the presence of different chemokines and their receptors in T cells, and we verified a higher expression of CXCR3 in the early stages of LCL (less than 30 days of infection) and a higher expression of CCR4 in the late stages of disease (more than 60 days of infection). We also observed a higher frequency of T cells producing IL-10 in the late stage of LCL. Using immunohistochemistry, we observed a higher expression of CCL7, CCL17 in lesions from late LCL, as well as CCR4 suggesting a preferential recruitment of regulatory T cells in the late LCL. Comparing lesions from LCL and DCL patients, we observed a higher frequency of CCL7 in DCL lesions. These results point out the importance of the chemokines, defining the different types of cells recruited to the site of the infection, which could be related to the outcome of infection as well as the clinical form observed.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-06-25T15:44:31Z No. of bitstreams: 1 1-s2.0-S0198885910004957-main.pdf: 1450332 bytes, checksum: f6a5e82e70e45252fca6bcd4b5ef0cae (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-06-27T21:02:35Z (GMT) No. of bitstreams: 1 1-s2.0-S0198885910004957-main.pdf: 1450332 bytes, checksum: f6a5e82e70e45252fca6bcd4b5ef0cae (MD5)Made available in DSpace on 2013-06-27T21:02:35Z (GMT). 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dc.title.pt_BR.fl_str_mv Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Human Immunology
title Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
spellingShingle Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
Campanelli, Ana Paula
Chemokines
Cutaneous leishmaniasis
Inflammation
title_short Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
title_full Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
title_fullStr Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
title_full_unstemmed Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
title_sort Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis
author Campanelli, Ana Paula
author_facet Campanelli, Ana Paula
Brodskyn, Claudia Ida
Boaventura, Viviane Sampaio
Silva, Claire
Barral-Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Brodskyn, Claudia Ida
Boaventura, Viviane Sampaio
Silva, Claire
Barral-Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Campanelli, Ana Paula
Brodskyn, Claudia Ida
Boaventura, Viviane Sampaio
Silva, Claire
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Campanelli, Ana Paula
Brodskyn, Claudia Ida
Boaventura, Viviane Sampaio
Silva, Claire
Barral-Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.por.fl_str_mv Chemokines
Cutaneous leishmaniasis
Inflammation
topic Chemokines
Cutaneous leishmaniasis
Inflammation
description Texto completo: acesso restrito. p.1220–1227
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-06-27T21:02:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12049
dc.identifier.issn.none.fl_str_mv 0198-8859
dc.identifier.number.pt_BR.fl_str_mv v. 71, n. 12
identifier_str_mv 0198-8859
v. 71, n. 12
url http://www.repositorio.ufba.br/ri/handle/ri/12049
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.humimm.2010.09.002
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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