Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

Detalhes bibliográficos
Autor(a) principal: Zingales,Bianca
Data de Publicação: 2014
Outros Autores: Miles,Michael A, Moraes,Carolina B, Luquetti,Alejandro, Guhl,Felipe, Schijman,Alejandro G, Ribeiro,Isabela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600828
Resumo: This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape.
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spelling Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversityin vitro drug screeningT. cruzigenetic diversityguidelinesThis opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape.Instituto Oswaldo Cruz, Ministério da Saúde2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600828Memórias do Instituto Oswaldo Cruz v.109 n.6 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140156info:eu-repo/semantics/openAccessZingales,BiancaMiles,Michael AMoraes,Carolina BLuquetti,AlejandroGuhl,FelipeSchijman,Alejandro GRibeiro,Isabelaeng2020-04-25T17:51:48Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:50.662Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
title Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
spellingShingle Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
Zingales,Bianca
in vitro drug screening
T. cruzi
genetic diversity
guidelines
title_short Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
title_full Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
title_fullStr Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
title_full_unstemmed Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
title_sort Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
author Zingales,Bianca
author_facet Zingales,Bianca
Miles,Michael A
Moraes,Carolina B
Luquetti,Alejandro
Guhl,Felipe
Schijman,Alejandro G
Ribeiro,Isabela
author_role author
author2 Miles,Michael A
Moraes,Carolina B
Luquetti,Alejandro
Guhl,Felipe
Schijman,Alejandro G
Ribeiro,Isabela
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zingales,Bianca
Miles,Michael A
Moraes,Carolina B
Luquetti,Alejandro
Guhl,Felipe
Schijman,Alejandro G
Ribeiro,Isabela
dc.subject.por.fl_str_mv in vitro drug screening
T. cruzi
genetic diversity
guidelines
topic in vitro drug screening
T. cruzi
genetic diversity
guidelines
dc.description.none.fl_txt_mv This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape.
description This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600828
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600828
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276140156
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.6 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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