Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection

Detalhes bibliográficos
Autor(a) principal: Vilela,Ricardo Chaves
Data de Publicação: 2011
Outros Autores: Benchimol,Marlene
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600009
Resumo: Trichomonas vaginalis and Tritrichomonas foetus are human and bovine parasites, respectively, that provoke the sexually transmitted disease trichomoniasis. These extracellular parasites adhere to the host epithelial cell surface. Although mucinases and proteases have been described as important proteins for parasite adhesion to epithelial cells, no studies have examined the role of the keratin molecules that cornify the vaginal epithelium. Here, we investigated the interaction of T. vaginalis and T. foetus with human keratin in vitro; additionally, adherence assays were performed in cattle with T. foetus to elucidate whether trichomonads were able to interact with keratin in vivo. We demonstrated that both T. vaginalisand T. foetusinteracted directly with keratin. Additionally, the trichomonads ingested and digested keratin, shedding new light on the Trichomonas infection process.
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spelling Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infectionTrichomonas vaginalisTritrichomonas foetusendocytosiskeratinparasite-cell interactionTrichomonas vaginalis and Tritrichomonas foetus are human and bovine parasites, respectively, that provoke the sexually transmitted disease trichomoniasis. These extracellular parasites adhere to the host epithelial cell surface. Although mucinases and proteases have been described as important proteins for parasite adhesion to epithelial cells, no studies have examined the role of the keratin molecules that cornify the vaginal epithelium. Here, we investigated the interaction of T. vaginalis and T. foetus with human keratin in vitro; additionally, adherence assays were performed in cattle with T. foetus to elucidate whether trichomonads were able to interact with keratin in vivo. We demonstrated that both T. vaginalisand T. foetusinteracted directly with keratin. Additionally, the trichomonads ingested and digested keratin, shedding new light on the Trichomonas infection process.Instituto Oswaldo Cruz, Ministério da Saúde2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600009Memórias do Instituto Oswaldo Cruz v.106 n.6 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000600009info:eu-repo/semantics/openAccessVilela,Ricardo ChavesBenchimol,Marleneeng2020-04-25T17:51:02Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:49.482Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
title Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
spellingShingle Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
Vilela,Ricardo Chaves
Trichomonas vaginalis
Tritrichomonas foetus
endocytosis
keratin
parasite-cell interaction
title_short Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
title_full Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
title_fullStr Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
title_full_unstemmed Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
title_sort Interaction of Trichomonas vaginalis and Tritrichomonas foetus with keratin: an important role in parasite infection
author Vilela,Ricardo Chaves
author_facet Vilela,Ricardo Chaves
Benchimol,Marlene
author_role author
author2 Benchimol,Marlene
author2_role author
dc.contributor.author.fl_str_mv Vilela,Ricardo Chaves
Benchimol,Marlene
dc.subject.por.fl_str_mv Trichomonas vaginalis
Tritrichomonas foetus
endocytosis
keratin
parasite-cell interaction
topic Trichomonas vaginalis
Tritrichomonas foetus
endocytosis
keratin
parasite-cell interaction
dc.description.none.fl_txt_mv Trichomonas vaginalis and Tritrichomonas foetus are human and bovine parasites, respectively, that provoke the sexually transmitted disease trichomoniasis. These extracellular parasites adhere to the host epithelial cell surface. Although mucinases and proteases have been described as important proteins for parasite adhesion to epithelial cells, no studies have examined the role of the keratin molecules that cornify the vaginal epithelium. Here, we investigated the interaction of T. vaginalis and T. foetus with human keratin in vitro; additionally, adherence assays were performed in cattle with T. foetus to elucidate whether trichomonads were able to interact with keratin in vivo. We demonstrated that both T. vaginalisand T. foetusinteracted directly with keratin. Additionally, the trichomonads ingested and digested keratin, shedding new light on the Trichomonas infection process.
description Trichomonas vaginalis and Tritrichomonas foetus are human and bovine parasites, respectively, that provoke the sexually transmitted disease trichomoniasis. These extracellular parasites adhere to the host epithelial cell surface. Although mucinases and proteases have been described as important proteins for parasite adhesion to epithelial cells, no studies have examined the role of the keratin molecules that cornify the vaginal epithelium. Here, we investigated the interaction of T. vaginalis and T. foetus with human keratin in vitro; additionally, adherence assays were performed in cattle with T. foetus to elucidate whether trichomonads were able to interact with keratin in vivo. We demonstrated that both T. vaginalisand T. foetusinteracted directly with keratin. Additionally, the trichomonads ingested and digested keratin, shedding new light on the Trichomonas infection process.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600009
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000600009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 n.6 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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