Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model

Detalhes bibliográficos
Autor(a) principal: Souza,Marcia Maria de
Data de Publicação: 2001
Outros Autores: Paraná,Raymundo, Trepo,Christian, Barbosa Jr,Aryon A, Oliveira,Irismar, Andrade,Zilton A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000300010
Resumo: Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-alpha proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-alpha on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.
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spelling Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new modelinterferon-alphahepatic fibrosisCapillaria hepaticaInterferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-alpha proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-alpha on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.Instituto Oswaldo Cruz, Ministério da Saúde2001-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000300010Memórias do Instituto Oswaldo Cruz v.96 n.3 2001reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762001000300010info:eu-repo/semantics/openAccessSouza,Marcia Maria deParaná,RaymundoTrepo,ChristianBarbosa Jr,Aryon AOliveira,IrismarAndrade,Zilton Aeng2020-04-25T17:48:33Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:10:14.577Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
title Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
spellingShingle Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
Souza,Marcia Maria de
interferon-alpha
hepatic fibrosis
Capillaria hepatica
title_short Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
title_full Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
title_fullStr Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
title_full_unstemmed Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
title_sort Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
author Souza,Marcia Maria de
author_facet Souza,Marcia Maria de
Paraná,Raymundo
Trepo,Christian
Barbosa Jr,Aryon A
Oliveira,Irismar
Andrade,Zilton A
author_role author
author2 Paraná,Raymundo
Trepo,Christian
Barbosa Jr,Aryon A
Oliveira,Irismar
Andrade,Zilton A
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza,Marcia Maria de
Paraná,Raymundo
Trepo,Christian
Barbosa Jr,Aryon A
Oliveira,Irismar
Andrade,Zilton A
dc.subject.por.fl_str_mv interferon-alpha
hepatic fibrosis
Capillaria hepatica
topic interferon-alpha
hepatic fibrosis
Capillaria hepatica
dc.description.none.fl_txt_mv Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-alpha proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-alpha on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.
description Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-alpha proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-alpha on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.
publishDate 2001
dc.date.none.fl_str_mv 2001-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000300010
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762001000300010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.96 n.3 2001
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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