Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model

Detalhes bibliográficos
Autor(a) principal: Souza, Marcia Maria de
Data de Publicação: 2001
Outros Autores: Paraná, Raymundo, Trepo, Christian, Barbosa Júnior, Aryon de Almeida, Oliveira, Irismar, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15059
Resumo: p. 343-348
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spelling Souza, Marcia Maria deParaná, RaymundoTrepo, ChristianBarbosa Júnior, Aryon de AlmeidaOliveira, IrismarAndrade, Zilton de Araújo2014-06-05T17:40:50Z2014-06-05T17:40:50Z20010074-0276http://repositorio.ufba.br/ri/handle/ri/15059v. 96, n. 3p. 343-348Interferon-a is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the liver, which terminates in cirrhosis 40 days after inoculation. The aim of this study was to test the anti-fibrotic effect of interferon in this experimental model. Evaluation of fibrosis was made by three separate methods: semi-quantitative histology, computerized morphometry and hydroxyproline measurements. Treatment with interferon-a proved to inhibit the development of fibrosis in this model, especially when doses of 500,000 and 800,000 IU were used for 60 days. Besides confirming the anti-fibrotic potential of interferon-a on a non-viral new experimental model of hepatic fibrosis, a clear-cut dose-dependent effect was observed.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-10T11:13:51Z No. of bitstreams: 1 Marcia Maria de Souza.pdf: 268140 bytes, checksum: 7fff68504aeab126900d3ab9acd1a56b (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-05T17:40:50Z (GMT) No. of bitstreams: 1 Marcia Maria de Souza.pdf: 268140 bytes, checksum: 7fff68504aeab126900d3ab9acd1a56b (MD5)Made available in DSpace on 2014-06-05T17:40:50Z (GMT). No. of bitstreams: 1 Marcia Maria de Souza.pdf: 268140 bytes, checksum: 7fff68504aeab126900d3ab9acd1a56b (MD5) Previous issue date: 2001http://dx.doi.org/10.1590/S0074-02762001000300010reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInterferon-aHepatic fibrosisCapillaria hepaticaCapillariaInterferonsHepatitis BHepatitis CHydroxyprolineEffect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New ModelMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALMarcia Maria de Souza.pdfMarcia Maria de Souza.pdfapplication/pdf268140https://repositorio.ufba.br/bitstream/ri/15059/1/Marcia%20Maria%20de%20Souza.pdf7fff68504aeab126900d3ab9acd1a56bMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15059/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTMarcia Maria de Souza.pdf.txtMarcia Maria de Souza.pdf.txtExtracted texttext/plain20007https://repositorio.ufba.br/bitstream/ri/15059/3/Marcia%20Maria%20de%20Souza.pdf.txt24a66ee5946b5b802987a127cc3c5bbfMD53ri/150592022-03-10 14:03:13.531oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-10T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
spellingShingle Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
Souza, Marcia Maria de
Interferon-a
Hepatic fibrosis
Capillaria hepatica
Capillaria
Interferons
Hepatitis B
Hepatitis C
Hydroxyproline
title_short Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
title_full Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
title_fullStr Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
title_full_unstemmed Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
title_sort Effect of Interferon-a on Experimental Septal Fibrosis of the Liver - Study with a New Model
author Souza, Marcia Maria de
author_facet Souza, Marcia Maria de
Paraná, Raymundo
Trepo, Christian
Barbosa Júnior, Aryon de Almeida
Oliveira, Irismar
Andrade, Zilton de Araújo
author_role author
author2 Paraná, Raymundo
Trepo, Christian
Barbosa Júnior, Aryon de Almeida
Oliveira, Irismar
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Marcia Maria de
Paraná, Raymundo
Trepo, Christian
Barbosa Júnior, Aryon de Almeida
Oliveira, Irismar
Andrade, Zilton de Araújo
dc.subject.por.fl_str_mv Interferon-a
Hepatic fibrosis
Capillaria hepatica
Capillaria
Interferons
Hepatitis B
Hepatitis C
Hydroxyproline
topic Interferon-a
Hepatic fibrosis
Capillaria hepatica
Capillaria
Interferons
Hepatitis B
Hepatitis C
Hydroxyproline
description p. 343-348
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2014-06-05T17:40:50Z
dc.date.available.fl_str_mv 2014-06-05T17:40:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15059
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.number.pt_BR.fl_str_mv v. 96, n. 3
identifier_str_mv 0074-0276
v. 96, n. 3
url http://repositorio.ufba.br/ri/handle/ri/15059
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0074-02762001000300010
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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