Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017 |
Resumo: | The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis. |
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Memórias do Instituto Oswaldo Cruz |
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Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouseThalidomideschistosomiasisangiogenesisfibrosisThe relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis.Instituto Oswaldo Cruz, Ministério da Saúde2007-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017Memórias do Instituto Oswaldo Cruz v.102 n.7 2007reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762007005000115info:eu-repo/semantics/openAccessLima,Camila BiãoIglesias,Karen BrasilAndrade,Zilton Aeng2020-04-25T17:50:13Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:15:23.603Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
title |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
spellingShingle |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse Lima,Camila Bião Thalidomide schistosomiasis angiogenesis fibrosis |
title_short |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
title_full |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
title_fullStr |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
title_full_unstemmed |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
title_sort |
Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse |
author |
Lima,Camila Bião |
author_facet |
Lima,Camila Bião Iglesias,Karen Brasil Andrade,Zilton A |
author_role |
author |
author2 |
Iglesias,Karen Brasil Andrade,Zilton A |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Lima,Camila Bião Iglesias,Karen Brasil Andrade,Zilton A |
dc.subject.por.fl_str_mv |
Thalidomide schistosomiasis angiogenesis fibrosis |
topic |
Thalidomide schistosomiasis angiogenesis fibrosis |
dc.description.none.fl_txt_mv |
The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis. |
description |
The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000700017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762007005000115 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.102 n.7 2007 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937701850185728 |