Rationale for the study of the human sex ratio in population studies of polluted environments
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690 |
Resumo: | The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome. |
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Rationale for the study of the human sex ratio in population studies of polluted environmentsSex RatioReproductionInfertilityEndocrine DisruptorsThe human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.A razão secundária de masculinidade em seres humanos continua suscitando bastante interesse. Em diversos países foi levantada a hipótese do papel da exposição química ambiental nas alterações associadas à razão de masculinidade. Tal efeito é sugerido, pelo menos teoricamente, pela observação de que o citrato de clomifene, droga utilizada no tratamento da infertilidade, com potentes propriedades estrogênicas e anti-estrogênicas, tem efeitos profundos sobre a razão de masculinidade, resultando no nascimento de uma proporção significativamente menor de machos. Utilizando um modelo causal baseado na identificação clínica de uma metodologia de efeito farmacológico adverso, pode-se melhorar a objetividade da avaliação da exposição ambiental significativa sobre esse desfecho reprodutivo em seres humanos.Reports in Public HealthCadernos de Saúde Pública2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690Reports in Public Health; Vol. 18 No. 2 (2002): March/AprilCadernos de Saúde Pública; v. 18 n. 2 (2002): Março/Abril1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3368https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3369Jarrell, Johninfo:eu-repo/semantics/openAccess2024-03-06T15:26:34Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/1690Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:01:59.003190Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Rationale for the study of the human sex ratio in population studies of polluted environments |
title |
Rationale for the study of the human sex ratio in population studies of polluted environments |
spellingShingle |
Rationale for the study of the human sex ratio in population studies of polluted environments Jarrell, John Sex Ratio Reproduction Infertility Endocrine Disruptors |
title_short |
Rationale for the study of the human sex ratio in population studies of polluted environments |
title_full |
Rationale for the study of the human sex ratio in population studies of polluted environments |
title_fullStr |
Rationale for the study of the human sex ratio in population studies of polluted environments |
title_full_unstemmed |
Rationale for the study of the human sex ratio in population studies of polluted environments |
title_sort |
Rationale for the study of the human sex ratio in population studies of polluted environments |
author |
Jarrell, John |
author_facet |
Jarrell, John |
author_role |
author |
dc.contributor.author.fl_str_mv |
Jarrell, John |
dc.subject.por.fl_str_mv |
Sex Ratio Reproduction Infertility Endocrine Disruptors |
topic |
Sex Ratio Reproduction Infertility Endocrine Disruptors |
description |
The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3368 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3369 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 18 No. 2 (2002): March/April Cadernos de Saúde Pública; v. 18 n. 2 (2002): Março/Abril 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1798943349674082304 |