On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls

Detalhes bibliográficos
Autor(a) principal: Costa,Eduardo de A.
Data de Publicação: 1995
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018
Resumo: The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease.
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spelling On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfallsMeningococcal DiseaseCase-selection BiasAnti-meningococcal B VaccineVaccine EfficacyNeisseria meningitidisThe present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz1995-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018Cadernos de Saúde Pública v.11 n.2 1995reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X1995000200018info:eu-repo/semantics/openAccessCosta,Eduardo de A.eng2003-09-29T00:00:00Zoai:scielo:S0102-311X1995000200018Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2003-09-29T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
title On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
spellingShingle On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
Costa,Eduardo de A.
Meningococcal Disease
Case-selection Bias
Anti-meningococcal B Vaccine
Vaccine Efficacy
Neisseria meningitidis
title_short On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
title_full On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
title_fullStr On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
title_full_unstemmed On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
title_sort On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
author Costa,Eduardo de A.
author_facet Costa,Eduardo de A.
author_role author
dc.contributor.author.fl_str_mv Costa,Eduardo de A.
dc.subject.por.fl_str_mv Meningococcal Disease
Case-selection Bias
Anti-meningococcal B Vaccine
Vaccine Efficacy
Neisseria meningitidis
topic Meningococcal Disease
Case-selection Bias
Anti-meningococcal B Vaccine
Vaccine Efficacy
Neisseria meningitidis
description The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease.
publishDate 1995
dc.date.none.fl_str_mv 1995-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-311X1995000200018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
dc.source.none.fl_str_mv Cadernos de Saúde Pública v.11 n.2 1995
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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