Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions

Detalhes bibliográficos
Autor(a) principal: Nadalin,Michele Regina
Data de Publicação: 2011
Outros Autores: Fregnani,Eduardo Rodrigues, Silva-Sousa,Yara Teresinha Correa, Perez,Danyel Elias da Cruz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402011000300008
Resumo: The aim of this study was to assess the immunohistochemical expression of syndecan-1 (CD138) and Ki-67 in radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors (KOT). Thirty-five RC, 22 DC and 17 KOT were used in the study and immunohistochemical reactions using anti-syndecan-1 and anti-Ki-67 antibodies were performed by the streptavidin-biotin-peroxidase method. Fisher's exact test and Spearman's correlation coefficient were used for statistical analysis of data. Among the studied lesions, no differences in the syndecan-1 expression were observed, but the suprabasal expression of Ki-67 was significantly higher in KOT (p<0.0001), when compared with RC and DC. In RC, there was positive correlation between the expression (p=0.02) and intensity (p=0.0001) of syndecan-1 and between the intensity of syndecan-1 and Ki-67 expression (p=0.01). In the KOT, Ki-67 expression in the suprabasal layer correlated positively with the expression (p=0.01) and intensity (p=0.01) of syndecan-1. The expression of syndecan-1 does not seem to be a determinant factor of the distinct histopathological features and biological behavior of the studied lesions. Nevertheless, positive correlation between syndecan-1 and a cell proliferation marker was observed in RC and KOT.
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spelling Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesionskeratocystic odontogenic tumorKi-67odontogenic cystssyndecan-1The aim of this study was to assess the immunohistochemical expression of syndecan-1 (CD138) and Ki-67 in radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors (KOT). Thirty-five RC, 22 DC and 17 KOT were used in the study and immunohistochemical reactions using anti-syndecan-1 and anti-Ki-67 antibodies were performed by the streptavidin-biotin-peroxidase method. Fisher's exact test and Spearman's correlation coefficient were used for statistical analysis of data. Among the studied lesions, no differences in the syndecan-1 expression were observed, but the suprabasal expression of Ki-67 was significantly higher in KOT (p<0.0001), when compared with RC and DC. In RC, there was positive correlation between the expression (p=0.02) and intensity (p=0.0001) of syndecan-1 and between the intensity of syndecan-1 and Ki-67 expression (p=0.01). In the KOT, Ki-67 expression in the suprabasal layer correlated positively with the expression (p=0.01) and intensity (p=0.01) of syndecan-1. The expression of syndecan-1 does not seem to be a determinant factor of the distinct histopathological features and biological behavior of the studied lesions. Nevertheless, positive correlation between syndecan-1 and a cell proliferation marker was observed in RC and KOT.Fundação Odontológica de Ribeirão Preto2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402011000300008Brazilian Dental Journal v.22 n.3 2011reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402011000300008info:eu-repo/semantics/openAccessNadalin,Michele ReginaFregnani,Eduardo RodriguesSilva-Sousa,Yara Teresinha CorreaPerez,Danyel Elias da Cruzeng2011-06-10T00:00:00Zoai:scielo:S0103-64402011000300008Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2011-06-10T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
title Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
spellingShingle Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
Nadalin,Michele Regina
keratocystic odontogenic tumor
Ki-67
odontogenic cysts
syndecan-1
title_short Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
title_full Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
title_fullStr Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
title_full_unstemmed Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
title_sort Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions
author Nadalin,Michele Regina
author_facet Nadalin,Michele Regina
Fregnani,Eduardo Rodrigues
Silva-Sousa,Yara Teresinha Correa
Perez,Danyel Elias da Cruz
author_role author
author2 Fregnani,Eduardo Rodrigues
Silva-Sousa,Yara Teresinha Correa
Perez,Danyel Elias da Cruz
author2_role author
author
author
dc.contributor.author.fl_str_mv Nadalin,Michele Regina
Fregnani,Eduardo Rodrigues
Silva-Sousa,Yara Teresinha Correa
Perez,Danyel Elias da Cruz
dc.subject.por.fl_str_mv keratocystic odontogenic tumor
Ki-67
odontogenic cysts
syndecan-1
topic keratocystic odontogenic tumor
Ki-67
odontogenic cysts
syndecan-1
description The aim of this study was to assess the immunohistochemical expression of syndecan-1 (CD138) and Ki-67 in radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors (KOT). Thirty-five RC, 22 DC and 17 KOT were used in the study and immunohistochemical reactions using anti-syndecan-1 and anti-Ki-67 antibodies were performed by the streptavidin-biotin-peroxidase method. Fisher's exact test and Spearman's correlation coefficient were used for statistical analysis of data. Among the studied lesions, no differences in the syndecan-1 expression were observed, but the suprabasal expression of Ki-67 was significantly higher in KOT (p<0.0001), when compared with RC and DC. In RC, there was positive correlation between the expression (p=0.02) and intensity (p=0.0001) of syndecan-1 and between the intensity of syndecan-1 and Ki-67 expression (p=0.01). In the KOT, Ki-67 expression in the suprabasal layer correlated positively with the expression (p=0.01) and intensity (p=0.01) of syndecan-1. The expression of syndecan-1 does not seem to be a determinant factor of the distinct histopathological features and biological behavior of the studied lesions. Nevertheless, positive correlation between syndecan-1 and a cell proliferation marker was observed in RC and KOT.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402011000300008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402011000300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402011000300008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.22 n.3 2011
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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