NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON

Detalhes bibliográficos
Autor(a) principal: Fonseca, Tesiê Leopoldo
Data de Publicação: 2009
Outros Autores: Von Groll, Andrea, Leitão, Suzana Guimarães, Leitão, Gilda Guimarães, Scaini, Carlos James, Ramos, Daniela Fernandes, Silva, Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Vittalle (Online)
Texto Completo: https://periodicos.furg.br/vittalle/article/view/948
Resumo: Non-tuberculous mycobacteria are environmental species of increasing clinical importance in the last years and have been reported as etiologic agent in various types of infections. Generally, they have great intrinsic resistance to ordinary antimicrobials conventional, which motivates to search new pharmacological alternatives, such as those obtained from natural sources. This study evaluated the activity of classic anti-tuberculosis drugs such as streptomycin (SMR), ethambutol (EMB), isoniazid (INH), rifampin (RIF) and crude extracts of plant from the Atlantic Forest (Brazil) against Mycobacterium fortuitum and Mycobacterium malmoense. It was observed the minimum inhibitory concentration (MIC) for M. fortuitum: EMB = 16μg/mL; SMR = 4μg/mL; INH and RIF 1μg/mL; crude extract Plathymenia foliolosa = 200μg/mL. For M. malmoense, MIC were: SMR = 4μg/mL; INH = 1μg/mL and RIF = 0.25μg/mL. EMB did not inhibit bacterial growth of this species. Active crude extracts against M. malmoense were Siparuna arianeae, Cedrela fissilis and Peschiera affinis that showed MIC = 200μg/mL, while Ficus gomelleria showed 100μg/mL.
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spelling NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ONATIVIDADE ANTIMICOBACTERIANA DE EXTRATOS VEGETAIS FRENTE A MYCOBACTERIUM FORTUITUM E MYCOBACTERIUM MALMOENSEatividade antimicobacterianaextratos vegetaisMycobacterium fortuitumMycobacterium malmoenseantimycobacterial activityvegetable extractsMycobacterium malmoense.Non-tuberculous mycobacteria are environmental species of increasing clinical importance in the last years and have been reported as etiologic agent in various types of infections. Generally, they have great intrinsic resistance to ordinary antimicrobials conventional, which motivates to search new pharmacological alternatives, such as those obtained from natural sources. This study evaluated the activity of classic anti-tuberculosis drugs such as streptomycin (SMR), ethambutol (EMB), isoniazid (INH), rifampin (RIF) and crude extracts of plant from the Atlantic Forest (Brazil) against Mycobacterium fortuitum and Mycobacterium malmoense. It was observed the minimum inhibitory concentration (MIC) for M. fortuitum: EMB = 16μg/mL; SMR = 4μg/mL; INH and RIF 1μg/mL; crude extract Plathymenia foliolosa = 200μg/mL. For M. malmoense, MIC were: SMR = 4μg/mL; INH = 1μg/mL and RIF = 0.25μg/mL. EMB did not inhibit bacterial growth of this species. Active crude extracts against M. malmoense were Siparuna arianeae, Cedrela fissilis and Peschiera affinis that showed MIC = 200μg/mL, while Ficus gomelleria showed 100μg/mL.As micobactérias não-tuberculosas são espécies ambientais com crescente relevância clínica, por sua relação com diversos tipos de infecções. Geralmente, apresentam maior resistência intrínseca aos antimicobacterianos convencionais, impulsionando assim a busca de novas alternativas farmacológicas, como as obtidas de fontes naturais. Este estudo avaliou a atividade de clássicos antituberculosos, como estreptomicina (SMR), etambutol (EMB), isoniazida (INH) e rifampicina (RIF), bem como extratos vegetais oriundos da Mata Atlântica (Brasil) frente ao Mycobacterium fortuitum e Mycobacterium malmoense. Foram observadas as seguintes concentrações mínimas inibitórias (CMI) para o M. fortuitum: EMB = 16µg/mL; SMR = 4µg/mL; INH e RIF 1µg/mL; extrato bruto Plathymenia foliolosa = 200µg/mL. Já para o M. malmoense, as CMI encontradas foram: SMR = 4µg/mL; INH = 1µg/mL e RIF = 0,25µg/mL. O EMB não inibiu o crescimento bacteriano desta espécie. Os compostos naturais ativos contra o M. malmoense foram os extratos Siparuna arianeae, Cedrela fissilis e Peschiera affinis, que apresentaram CMI de 200µg/mL, enquanto a CMI de Ficus gomelleria foi de 100µg/mL.Universidade Federal do Rio Grande2009-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.furg.br/vittalle/article/view/94810.14295/vittalle.v20i1.948VITTALLE - Revista de Ciências da Saúde; v. 20 n. 1 (2008); 65-722177-78531413-3563reponame:Vittalle (Online)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGporhttps://periodicos.furg.br/vittalle/article/view/948/394Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúdeinfo:eu-repo/semantics/openAccessFonseca, Tesiê LeopoldoVon Groll, AndreaLeitão, Suzana GuimarãesLeitão, Gilda GuimarãesScaini, Carlos JamesRamos, Daniela FernandesSilva, Pedro Eduardo Almeida da2013-12-11T17:34:17Zoai:periodicos.furg.br:article/948Revistahttps://periodicos.furg.br/vittallePUBhttps://periodicos.furg.br/vittalle/oaivittalle@furg.br2177-78531413-3563opendoar:2013-12-11T17:34:17Vittalle (Online) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
ATIVIDADE ANTIMICOBACTERIANA DE EXTRATOS VEGETAIS FRENTE A MYCOBACTERIUM FORTUITUM E MYCOBACTERIUM MALMOENSE
title NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
spellingShingle NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
Fonseca, Tesiê Leopoldo
atividade antimicobacteriana
extratos vegetais
Mycobacterium fortuitum
Mycobacterium malmoenseantimycobacterial activity
vegetable extracts
Mycobacterium malmoense.
title_short NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
title_full NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
title_fullStr NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
title_full_unstemmed NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
title_sort NATURAL EXTRACTS WITH ANTI-MYCOBACTERIUM ACTIVITY ON
author Fonseca, Tesiê Leopoldo
author_facet Fonseca, Tesiê Leopoldo
Von Groll, Andrea
Leitão, Suzana Guimarães
Leitão, Gilda Guimarães
Scaini, Carlos James
Ramos, Daniela Fernandes
Silva, Pedro Eduardo Almeida da
author_role author
author2 Von Groll, Andrea
Leitão, Suzana Guimarães
Leitão, Gilda Guimarães
Scaini, Carlos James
Ramos, Daniela Fernandes
Silva, Pedro Eduardo Almeida da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Tesiê Leopoldo
Von Groll, Andrea
Leitão, Suzana Guimarães
Leitão, Gilda Guimarães
Scaini, Carlos James
Ramos, Daniela Fernandes
Silva, Pedro Eduardo Almeida da
dc.subject.por.fl_str_mv atividade antimicobacteriana
extratos vegetais
Mycobacterium fortuitum
Mycobacterium malmoenseantimycobacterial activity
vegetable extracts
Mycobacterium malmoense.
topic atividade antimicobacteriana
extratos vegetais
Mycobacterium fortuitum
Mycobacterium malmoenseantimycobacterial activity
vegetable extracts
Mycobacterium malmoense.
description Non-tuberculous mycobacteria are environmental species of increasing clinical importance in the last years and have been reported as etiologic agent in various types of infections. Generally, they have great intrinsic resistance to ordinary antimicrobials conventional, which motivates to search new pharmacological alternatives, such as those obtained from natural sources. This study evaluated the activity of classic anti-tuberculosis drugs such as streptomycin (SMR), ethambutol (EMB), isoniazid (INH), rifampin (RIF) and crude extracts of plant from the Atlantic Forest (Brazil) against Mycobacterium fortuitum and Mycobacterium malmoense. It was observed the minimum inhibitory concentration (MIC) for M. fortuitum: EMB = 16μg/mL; SMR = 4μg/mL; INH and RIF 1μg/mL; crude extract Plathymenia foliolosa = 200μg/mL. For M. malmoense, MIC were: SMR = 4μg/mL; INH = 1μg/mL and RIF = 0.25μg/mL. EMB did not inhibit bacterial growth of this species. Active crude extracts against M. malmoense were Siparuna arianeae, Cedrela fissilis and Peschiera affinis that showed MIC = 200μg/mL, while Ficus gomelleria showed 100μg/mL.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.furg.br/vittalle/article/view/948
10.14295/vittalle.v20i1.948
url https://periodicos.furg.br/vittalle/article/view/948
identifier_str_mv 10.14295/vittalle.v20i1.948
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.furg.br/vittalle/article/view/948/394
dc.rights.driver.fl_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande
publisher.none.fl_str_mv Universidade Federal do Rio Grande
dc.source.none.fl_str_mv VITTALLE - Revista de Ciências da Saúde; v. 20 n. 1 (2008); 65-72
2177-7853
1413-3563
reponame:Vittalle (Online)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Vittalle (Online)
collection Vittalle (Online)
repository.name.fl_str_mv Vittalle (Online) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv vittalle@furg.br
_version_ 1797041718505242624

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