Molecular pharmacological dissection of short- and long-term memory
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/2993 |
Resumo: | It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTMintact for the same task in the same animal. The effect of a large number of treatments infused into the hippocampus, amygdala, and entorhinal, posterior parietal or prefrontal cortex on STM and LTMof a one-trial stepdown inhibitory avoidance task was studied. The animals were tested at 1.5 h for STM, and again at 24 h for LTM. The treatments were given after training. Eleven different treatments blocked STM without affecting LTM. Eighteen treatments affected the two memory types differentially, either blocking or enhancing LTM alone. Thus, STM is separate from, and parallel to the first hours of processing of, LTM of that task. The mechanisms ofSTMare different from those of LTM. The former do not include gene expression or protein synthesis; the latter include a double peak of cAMP-dependent protein kinase activity, accompanied by the phosphorylation of CREB, and both gene expression and protein synthesis. Possible cellular and molecular events that do not requiremRNAor protein synthesis should account for STM. These might include a hyperactivation of glutamate AMPA receptors, ribosome changes, or the exocytosis of glycoproteins that participate in cell addition. |
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Izquierdo, Luciana AdrianaBarros, Daniela MartiVianna, Mônica Ryff Moreira RocaCoitinho, Adriana SimonSilva, Tiago Luís de Dedavid eChoi, Humberto KukhyunMoletta, BeatrizMedina, Jorge HoracioIzquierdo, Ivan Antônio2012-12-13T22:46:51Z2012-12-13T22:46:51Z2002IZQUIERDO, Luciana Adriana et al. Molecular pharmacological dissection of short- and long-term memory. Cellular and Molecular Neurobiology, v. 22, n. 3, p. 269-287, 2002. Disponível em:<http://download.springer.com/static/pdf/999/art%253A10.1023%252FA%253A1020715800956.pdf?auth66=1353576341_f7fd2c4e2647b5e33edda4988cb3554c&ext=.pdf>. Acesso em: 22 nov. 2012.http://repositorio.furg.br/handle/1/2993It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTMintact for the same task in the same animal. The effect of a large number of treatments infused into the hippocampus, amygdala, and entorhinal, posterior parietal or prefrontal cortex on STM and LTMof a one-trial stepdown inhibitory avoidance task was studied. The animals were tested at 1.5 h for STM, and again at 24 h for LTM. The treatments were given after training. Eleven different treatments blocked STM without affecting LTM. Eighteen treatments affected the two memory types differentially, either blocking or enhancing LTM alone. Thus, STM is separate from, and parallel to the first hours of processing of, LTM of that task. The mechanisms ofSTMare different from those of LTM. The former do not include gene expression or protein synthesis; the latter include a double peak of cAMP-dependent protein kinase activity, accompanied by the phosphorylation of CREB, and both gene expression and protein synthesis. Possible cellular and molecular events that do not requiremRNAor protein synthesis should account for STM. These might include a hyperactivation of glutamate AMPA receptors, ribosome changes, or the exocytosis of glycoproteins that participate in cell addition.engShort-term memoryLong-term memoryMemory typesMolecular pharmacological dissection of short- and long-term memoryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALMolecular pharmacological dissection of short- and long-term memory.pdfMolecular pharmacological dissection of short- and long-term memory.pdfapplication/pdf602015https://repositorio.furg.br/bitstream/1/2993/1/Molecular%20pharmacological%20dissection%20of%20short-%20and%20long-term%20memory.pdf29f5a0ec4f879096cc1886399debb728MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81724https://repositorio.furg.br/bitstream/1/2993/2/license.txt5b92b9704b4f13242d70e45ddef35a68MD52open access1/29932019-11-13 19:52:33.554open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-13T22:52:33Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Molecular pharmacological dissection of short- and long-term memory |
title |
Molecular pharmacological dissection of short- and long-term memory |
spellingShingle |
Molecular pharmacological dissection of short- and long-term memory Izquierdo, Luciana Adriana Short-term memory Long-term memory Memory types |
title_short |
Molecular pharmacological dissection of short- and long-term memory |
title_full |
Molecular pharmacological dissection of short- and long-term memory |
title_fullStr |
Molecular pharmacological dissection of short- and long-term memory |
title_full_unstemmed |
Molecular pharmacological dissection of short- and long-term memory |
title_sort |
Molecular pharmacological dissection of short- and long-term memory |
author |
Izquierdo, Luciana Adriana |
author_facet |
Izquierdo, Luciana Adriana Barros, Daniela Marti Vianna, Mônica Ryff Moreira Roca Coitinho, Adriana Simon Silva, Tiago Luís de Dedavid e Choi, Humberto Kukhyun Moletta, Beatriz Medina, Jorge Horacio Izquierdo, Ivan Antônio |
author_role |
author |
author2 |
Barros, Daniela Marti Vianna, Mônica Ryff Moreira Roca Coitinho, Adriana Simon Silva, Tiago Luís de Dedavid e Choi, Humberto Kukhyun Moletta, Beatriz Medina, Jorge Horacio Izquierdo, Ivan Antônio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Izquierdo, Luciana Adriana Barros, Daniela Marti Vianna, Mônica Ryff Moreira Roca Coitinho, Adriana Simon Silva, Tiago Luís de Dedavid e Choi, Humberto Kukhyun Moletta, Beatriz Medina, Jorge Horacio Izquierdo, Ivan Antônio |
dc.subject.por.fl_str_mv |
Short-term memory Long-term memory Memory types |
topic |
Short-term memory Long-term memory Memory types |
description |
It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTMintact for the same task in the same animal. The effect of a large number of treatments infused into the hippocampus, amygdala, and entorhinal, posterior parietal or prefrontal cortex on STM and LTMof a one-trial stepdown inhibitory avoidance task was studied. The animals were tested at 1.5 h for STM, and again at 24 h for LTM. The treatments were given after training. Eleven different treatments blocked STM without affecting LTM. Eighteen treatments affected the two memory types differentially, either blocking or enhancing LTM alone. Thus, STM is separate from, and parallel to the first hours of processing of, LTM of that task. The mechanisms ofSTMare different from those of LTM. The former do not include gene expression or protein synthesis; the latter include a double peak of cAMP-dependent protein kinase activity, accompanied by the phosphorylation of CREB, and both gene expression and protein synthesis. Possible cellular and molecular events that do not requiremRNAor protein synthesis should account for STM. These might include a hyperactivation of glutamate AMPA receptors, ribosome changes, or the exocytosis of glycoproteins that participate in cell addition. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002 |
dc.date.accessioned.fl_str_mv |
2012-12-13T22:46:51Z |
dc.date.available.fl_str_mv |
2012-12-13T22:46:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
IZQUIERDO, Luciana Adriana et al. Molecular pharmacological dissection of short- and long-term memory. Cellular and Molecular Neurobiology, v. 22, n. 3, p. 269-287, 2002. Disponível em:<http://download.springer.com/static/pdf/999/art%253A10.1023%252FA%253A1020715800956.pdf?auth66=1353576341_f7fd2c4e2647b5e33edda4988cb3554c&ext=.pdf>. Acesso em: 22 nov. 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/2993 |
identifier_str_mv |
IZQUIERDO, Luciana Adriana et al. Molecular pharmacological dissection of short- and long-term memory. Cellular and Molecular Neurobiology, v. 22, n. 3, p. 269-287, 2002. Disponível em:<http://download.springer.com/static/pdf/999/art%253A10.1023%252FA%253A1020715800956.pdf?auth66=1353576341_f7fd2c4e2647b5e33edda4988cb3554c&ext=.pdf>. Acesso em: 22 nov. 2012. |
url |
http://repositorio.furg.br/handle/1/2993 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
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Universidade Federal do Rio Grande (FURG) |
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