USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/952 |
Resumo: | Pemphigoid of the mucous membranes is an autoimmune, vesiculobullous, chronic disease characterized by the presence of suprabasal or subepithelial blisters on mucous membranes. It predominantly affects a fixed older age, generally from the fourth decade of life. Ocular involvement is common, with the formation of scars characteristic of this type of pemphigoid, and when the conjunctiva is affected, it can lead the patient to blindness. Those with this alteration may have involvement of the oral mucous membranes, with the inserted gingiva being the most affected site, triggering a condition of desquamative gingivitis, as well as painful and bleeding bullous lesions with deep cleavage. The etiology is unknown, but some authors associate pemphigoid with the use of certain drugs such as Captopril, Furosemide and Amoxicillin. Diagnosis is based on clinical history, perilesional biopsy and direct immunofluorescence. Histopathological examinations show the separation of the basal epithelial layer from the connective tissue itself, vacuolation in the basal lamina under an intact epithelium, and deposits of IgG and C3 in the basal membrane, which can be identified through direct immunofluorescence. The treatment is done in a multidisciplinary way, through topical or systemic corticosteroid therapy, depending on the severity of the disease, in addition to laser therapy and drug associations. The present work aims to present a case of pemphigoid of the mucous membranes, where the patient presented lesions in the eyes and in the oral mucosa, with a diagnosis confirmed through histopathology, in concomitant treatment of stomatology with other medical specialties, such as ophthalmology, presenting satisfactory evolution of the mouth injuries. |
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USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALYUTILIZAÇÃO DE CORTICOSTEROIDE TÓPICO OCLUSIVO NO TRATAMENTO DO PENFIGOIDE CICATRICIAL DAS MEMBRANAS MUCOSAS EM PACIENTE APRESENTANDO GENGIVITE DESCAMATIVAPenfigoide. Membranas Mucosas. Estomatologia. Doenças Crônicas.Pemphigoid. Mucous membranes. Stomatology. Chronic diseases.Pemphigoid of the mucous membranes is an autoimmune, vesiculobullous, chronic disease characterized by the presence of suprabasal or subepithelial blisters on mucous membranes. It predominantly affects a fixed older age, generally from the fourth decade of life. Ocular involvement is common, with the formation of scars characteristic of this type of pemphigoid, and when the conjunctiva is affected, it can lead the patient to blindness. Those with this alteration may have involvement of the oral mucous membranes, with the inserted gingiva being the most affected site, triggering a condition of desquamative gingivitis, as well as painful and bleeding bullous lesions with deep cleavage. The etiology is unknown, but some authors associate pemphigoid with the use of certain drugs such as Captopril, Furosemide and Amoxicillin. Diagnosis is based on clinical history, perilesional biopsy and direct immunofluorescence. Histopathological examinations show the separation of the basal epithelial layer from the connective tissue itself, vacuolation in the basal lamina under an intact epithelium, and deposits of IgG and C3 in the basal membrane, which can be identified through direct immunofluorescence. The treatment is done in a multidisciplinary way, through topical or systemic corticosteroid therapy, depending on the severity of the disease, in addition to laser therapy and drug associations. The present work aims to present a case of pemphigoid of the mucous membranes, where the patient presented lesions in the eyes and in the oral mucosa, with a diagnosis confirmed through histopathology, in concomitant treatment of stomatology with other medical specialties, such as ophthalmology, presenting satisfactory evolution of the mouth injuries.Penfigoide das membranas mucosas, é uma doença autoimune, vesiculobolhosa, de caráter crônico, que se caracteriza pela presença de bolhas suprabasais, ou subepiteliais, em membranas mucosas. Acomete predominantemente fixa etária mais elevada, geralmente, a partir da quarta década de vida. O envolvimento ocular é costumaz, ocorrendo a formação de cicatrizes característica desse tipo de penfigoide, e quando afetada a conjuntiva, pode levar o paciente à cegueira. Os portadores desta alteração podem apresentar envolvimento das mucosas orais, sendo a gengiva inserida o sítio mais afetado, desencadeando um quadro de gengivite descamativa, além de lesões bolhosas de clivagem profunda, doloridas e sangrantes. A etiologia é desconhecida, mas alguns autores associam o penfigoide ao uso de certos fármacos como Captopril, Furosemida e Amoxicilina. O diagnóstico é baseado na história clínica, biópsia perilesional e imunofluorescência direta. Nos exames histopatológicos, observa-se a separação da camada basal epitelial do tecido conjuntivo propriamente dito, vacuolização na lâmina basal sob um epitélio íntegro, e, depósitos de IgG e C3 na membrana basal, que podem ser identificados através de imunofluorescência direta. O tratamento é feito de forma multiprofissional, através de corticosteroideterapia, tópica ou de forma sistêmica, a depender da gravidade da doença, além de laserterapia e associações medicamentosas. O presente trabalho tem por objetivo apresentar um caso de penfigoide das membranas mucosas, onde o paciente apresentava lesões oculares e em mucosa oral, tendo diagnóstico confirmado através de histopatologia, em tratamento concomitante da estomatologia com outras especialidades médicas, como oftalmologia, apresentando evolução satisfatória das lesões bucais.Specialized Dentistry Group2023-11-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/95210.36557/2674-8169.2023v5n5p3821-3827Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 5 (2023): BJIHS QUALIS B3; 3821-3827Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 5 (2023): BJIHS QUALIS B3; 3821-3827Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 5 (2023): BJIHS QUALIS B3; 3821-38272674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/952/1061Copyright (c) 2023 Antonio Fabricio Alves Ferreira, Sávio José da Silva Brito, Déborah Rocha Seixas , Vinicios Fernando Silva da Silva , Vinicius Ribeiro Monteiro , Maria Clara Costa Guimarães Barbosa , Ingrid Guimarães Reis , Evanio da Silva , Paulo Reis Lião Silva , Rafaela Santana Freitas Monteiro https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFerreira, Antonio Fabricio AlvesBrito, Sávio José da Silva Seixas , Déborah Rocha Silva , Vinicios Fernando Silva daMonteiro , Vinicius RibeiroBarbosa , Maria Clara Costa GuimarãesReis , Ingrid GuimarãesSilva , Evanio da Silva , Paulo Reis LiãoMonteiro , Rafaela Santana Freitas2023-11-24T23:14:44Zoai:ojs.bjihs.emnuvens.com.br:article/952Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2023-11-24T23:14:44Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY UTILIZAÇÃO DE CORTICOSTEROIDE TÓPICO OCLUSIVO NO TRATAMENTO DO PENFIGOIDE CICATRICIAL DAS MEMBRANAS MUCOSAS EM PACIENTE APRESENTANDO GENGIVITE DESCAMATIVA |
title |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY |
spellingShingle |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY Ferreira, Antonio Fabricio Alves Penfigoide. Membranas Mucosas. Estomatologia. Doenças Crônicas. Pemphigoid. Mucous membranes. Stomatology. Chronic diseases. |
title_short |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY |
title_full |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY |
title_fullStr |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY |
title_full_unstemmed |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY |
title_sort |
USE OF OCCLUSIVE TOPICAL CORTICOSTEROIDS IN THE TREATMENT OF PEMPHIGOID SCARRING OF MUCOUS MEMBRANES IN A PATIENT WITH GINGIVITIS SCALY |
author |
Ferreira, Antonio Fabricio Alves |
author_facet |
Ferreira, Antonio Fabricio Alves Brito, Sávio José da Silva Seixas , Déborah Rocha Silva , Vinicios Fernando Silva da Monteiro , Vinicius Ribeiro Barbosa , Maria Clara Costa Guimarães Reis , Ingrid Guimarães Silva , Evanio da Silva , Paulo Reis Lião Monteiro , Rafaela Santana Freitas |
author_role |
author |
author2 |
Brito, Sávio José da Silva Seixas , Déborah Rocha Silva , Vinicios Fernando Silva da Monteiro , Vinicius Ribeiro Barbosa , Maria Clara Costa Guimarães Reis , Ingrid Guimarães Silva , Evanio da Silva , Paulo Reis Lião Monteiro , Rafaela Santana Freitas |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Antonio Fabricio Alves Brito, Sávio José da Silva Seixas , Déborah Rocha Silva , Vinicios Fernando Silva da Monteiro , Vinicius Ribeiro Barbosa , Maria Clara Costa Guimarães Reis , Ingrid Guimarães Silva , Evanio da Silva , Paulo Reis Lião Monteiro , Rafaela Santana Freitas |
dc.subject.por.fl_str_mv |
Penfigoide. Membranas Mucosas. Estomatologia. Doenças Crônicas. Pemphigoid. Mucous membranes. Stomatology. Chronic diseases. |
topic |
Penfigoide. Membranas Mucosas. Estomatologia. Doenças Crônicas. Pemphigoid. Mucous membranes. Stomatology. Chronic diseases. |
description |
Pemphigoid of the mucous membranes is an autoimmune, vesiculobullous, chronic disease characterized by the presence of suprabasal or subepithelial blisters on mucous membranes. It predominantly affects a fixed older age, generally from the fourth decade of life. Ocular involvement is common, with the formation of scars characteristic of this type of pemphigoid, and when the conjunctiva is affected, it can lead the patient to blindness. Those with this alteration may have involvement of the oral mucous membranes, with the inserted gingiva being the most affected site, triggering a condition of desquamative gingivitis, as well as painful and bleeding bullous lesions with deep cleavage. The etiology is unknown, but some authors associate pemphigoid with the use of certain drugs such as Captopril, Furosemide and Amoxicillin. Diagnosis is based on clinical history, perilesional biopsy and direct immunofluorescence. Histopathological examinations show the separation of the basal epithelial layer from the connective tissue itself, vacuolation in the basal lamina under an intact epithelium, and deposits of IgG and C3 in the basal membrane, which can be identified through direct immunofluorescence. The treatment is done in a multidisciplinary way, through topical or systemic corticosteroid therapy, depending on the severity of the disease, in addition to laser therapy and drug associations. The present work aims to present a case of pemphigoid of the mucous membranes, where the patient presented lesions in the eyes and in the oral mucosa, with a diagnosis confirmed through histopathology, in concomitant treatment of stomatology with other medical specialties, such as ophthalmology, presenting satisfactory evolution of the mouth injuries. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/952 10.36557/2674-8169.2023v5n5p3821-3827 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/952 |
identifier_str_mv |
10.36557/2674-8169.2023v5n5p3821-3827 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/952/1061 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 5 (2023): BJIHS QUALIS B3; 3821-3827 Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 5 (2023): BJIHS QUALIS B3; 3821-3827 Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 5 (2023): BJIHS QUALIS B3; 3821-3827 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798441610805248 |