CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1430 |
Resumo: | Immunology emerges as a protagonist in understanding autoimmune diseases of the endocrine system. Autoimmune diseases represent a significant challenge, as they involve an immune response that, instead of protecting the body, is mistakenly directed against its own cells and tissues. In the context of the endocrine system, where hormones play a crucial role in regulating diverse bodily functions, autoimmune manifestations introduce an additional layer of complexity. Objective: This article proposes a comprehensive exploration of endocrine diseases, highlighting not only the physiological foundations but also clinical challenges and therapeutic innovations. Methodology: The research was carried out through online access in the Scientific Electronic Library Online (SCIELO), PubMed, Latin American Caribbean Literature in Health Sciences (LILACS). in the month of January 2024. Analytical reading of the articles with the theme of the theme was carried out, upon reading the articles were subjected to inclusion and exclusion criteria, within the inclusion criteria original articles were considered, which addressed the researched topic and allowed full access to the study content, published between 2015 and 2023, in Portuguese and English. Results and Discussions: The results obtained in this investigation reveal a complex panorama of the interactions between the immune system and autoimmune diseases of the endocrine system. In-depth analysis of the collected samples highlights specific immune response patterns that directly correlate with the manifestation of these pathologies. When examining the data, there is clear evidence of immune dysfunction, reflected in autoimmune responses directed against endocrine glands. The presence of specific markers and changes in molecular profiles supports the hypothesis that the immune system plays a central role in the etiology of these conditions. The discussion of these results contextualizes the findings in the current scientific scenario, comparing them with previous studies and highlighting divergences or convergences. A clearer understanding of the underlying immunological mechanisms allows us to speculate on possible therapeutic strategies. Conclusion: Challenging immunology proves to be fundamental for understanding autoimmune diseases that affect the endocrine system. By exploring in depth, the complex interactions between the immune system and endocrine glands, this study contributes significantly to the understanding of these pathologies. The results clearly demonstrate the preponderant influence of the immune system on the manifestations of these diseases, suggesting promising therapeutic targets. Meticulous data analysis highlights consistent patterns of autoimmune response, providing valuable insights for future investigations and clinical interventions. |
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CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEMIMUNOLOGIA DESAFIADORA: UMA ABORDAGEM PROFUNDA NAS DOENÇAS AUTOIMUNE DO SISTEMA ENDÓCRINO Doenças Endócrinas; Mecanismo de ação; Doença de Addison; Tireoidite de Hashimoto; Diabetes tipo I.Endocrine Diseases; Mechanism of action; Addison's disease; Hashimoto's thyroiditis; Diabetes I.Immunology emerges as a protagonist in understanding autoimmune diseases of the endocrine system. Autoimmune diseases represent a significant challenge, as they involve an immune response that, instead of protecting the body, is mistakenly directed against its own cells and tissues. In the context of the endocrine system, where hormones play a crucial role in regulating diverse bodily functions, autoimmune manifestations introduce an additional layer of complexity. Objective: This article proposes a comprehensive exploration of endocrine diseases, highlighting not only the physiological foundations but also clinical challenges and therapeutic innovations. Methodology: The research was carried out through online access in the Scientific Electronic Library Online (SCIELO), PubMed, Latin American Caribbean Literature in Health Sciences (LILACS). in the month of January 2024. Analytical reading of the articles with the theme of the theme was carried out, upon reading the articles were subjected to inclusion and exclusion criteria, within the inclusion criteria original articles were considered, which addressed the researched topic and allowed full access to the study content, published between 2015 and 2023, in Portuguese and English. Results and Discussions: The results obtained in this investigation reveal a complex panorama of the interactions between the immune system and autoimmune diseases of the endocrine system. In-depth analysis of the collected samples highlights specific immune response patterns that directly correlate with the manifestation of these pathologies. When examining the data, there is clear evidence of immune dysfunction, reflected in autoimmune responses directed against endocrine glands. The presence of specific markers and changes in molecular profiles supports the hypothesis that the immune system plays a central role in the etiology of these conditions. The discussion of these results contextualizes the findings in the current scientific scenario, comparing them with previous studies and highlighting divergences or convergences. A clearer understanding of the underlying immunological mechanisms allows us to speculate on possible therapeutic strategies. Conclusion: Challenging immunology proves to be fundamental for understanding autoimmune diseases that affect the endocrine system. By exploring in depth, the complex interactions between the immune system and endocrine glands, this study contributes significantly to the understanding of these pathologies. The results clearly demonstrate the preponderant influence of the immune system on the manifestations of these diseases, suggesting promising therapeutic targets. Meticulous data analysis highlights consistent patterns of autoimmune response, providing valuable insights for future investigations and clinical interventions.A imunologia é protagonista na compreensão das doenças autoimunes do sistema endócrino. As doenças autoimunes representam um desafio significativo, pois envolvem uma resposta imunológica que, em vez de proteger o organismo, direciona-se, erroneamente, contra suas próprias células e tecidos. No contexto do sistema endócrino, onde hormônios desempenham um papel crucial na regulação de diversas funções corporais, as manifestações autoimunes introduzem uma camada adicional de complexidade. Objetivo: Explicar as doenças endócrinas, destacando os fundamentos fisiológicos, os desafios clínicos e as inovações terapêuticas. Metodologia: A pesquisa foi realizada através do acesso online nas bases de Scientific Electronic Library Online (SCIELO), PubMed, Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS), no mês de janeiro de 2024. Foi realizada a leitura analítica dos artigos com a temática do tema, mediante a leitura os artigos foram submetidos a critérios de inclusão e exclusão, dentro os de inclusão foram considerados artigos originais, que abordassem o tema pesquisado e permitissem acesso integral ao conteúdo do estudo, publicados no período de 2015 a 2023, em português e inglês. Resultados e Discussões: Os resultados obtidos nesta investigação revelam um panorama complexo das interações entre o sistema imunológico e as doenças autoimunes do sistema endócrino. A análise aprofundada das amostras coletadas destaca padrões específicos de resposta imunológica que se correlacionam diretamente com a manifestação dessas patologias. Ao examinar os dados, observa-se uma clara evidência de disfunção imunológica, refletida em respostas autoimunes direcionadas contra as glândulas endócrinas. A presença de marcadores específicos e alterações nos perfis moleculares sustenta a hipótese de que o sistema imunológico desempenha um papel central na etiologia dessas condições. A discussão desses resultados contextualiza as descobertas no cenário científico atual, comparando-as com estudos anteriores e destacando divergências ou convergências. A compreensão mais clara dos mecanismos imunológicos subjacentes permite especular sobre possíveis estratégias terapêuticas. Conclusão: A imunologia desafiadora revela-se fundamental para a compreensão das doenças autoimunes que afetam o sistema endócrino. Ao explorar de forma aprofundada as complexas interações entre o sistema imunológico e as glândulas endócrinas, este estudo contribui, significativamente, para o entendimento dessas patologias. Os resultados evidenciam, claramente, a influência preponderante do sistema imunológico nas manifestações dessas doenças, sugerindo alvos terapêuticos promissores. A análise meticulosa dos dados destaca padrões consistentes de resposta autoimune, fornecendo insights valiosos para futuras investigações e intervenções clínicas.Specialized Dentistry Group2024-02-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/143010.36557/2674-8169.2024v6n2p724-745Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 724-745Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 724-745Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 724-7452674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1430/1611Copyright (c) 2024 Ítalo Íris Boiba Rodrigues da Cunha, Keit Maciel da Gama, Álvaro Sanataniel Pereira dos Santos , Nicole Mendonça Fernandes Coelho, Ana Luiza Pereira de Aguiar , Vinícius de Lima Santana, Keila Cristiane Batista do Valle, Ytafaella Oliveira Santana , Lívia Fernanda Sousa de Melo , Daniel Pereira Pio Suwa, Alexandre Felipe Bastos Sampaio , Helcio Cavalcante Barbosa https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCunha, Ítalo Íris Boiba Rodrigues daGama, Keit Maciel daSantos , Álvaro Sanataniel Pereira dosCoelho, Nicole Mendonça FernandesAguiar , Ana Luiza Pereira deSantana, Vinícius de LimaValle, Keila Cristiane Batista doSantana , Ytafaella OliveiraMelo , Lívia Fernanda Sousa deSuwa, Daniel Pereira PioSampaio , Alexandre Felipe BastosBarbosa , Helcio Cavalcante2024-03-06T23:33:41Zoai:ojs.bjihs.emnuvens.com.br:article/1430Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-03-06T23:33:41Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM IMUNOLOGIA DESAFIADORA: UMA ABORDAGEM PROFUNDA NAS DOENÇAS AUTOIMUNE DO SISTEMA ENDÓCRINO |
title |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM |
spellingShingle |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM Cunha, Ítalo Íris Boiba Rodrigues da Doenças Endócrinas; Mecanismo de ação; Doença de Addison; Tireoidite de Hashimoto; Diabetes tipo I. Endocrine Diseases; Mechanism of action; Addison's disease; Hashimoto's thyroiditis; Diabetes I. |
title_short |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM |
title_full |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM |
title_fullStr |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM |
title_full_unstemmed |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM |
title_sort |
CHALLENGING IMMUNOLOGY: A DEEP APPROACH TO AUTOIMMUNE DISEASES OF THE ENDOCRINE SYSTEM |
author |
Cunha, Ítalo Íris Boiba Rodrigues da |
author_facet |
Cunha, Ítalo Íris Boiba Rodrigues da Gama, Keit Maciel da Santos , Álvaro Sanataniel Pereira dos Coelho, Nicole Mendonça Fernandes Aguiar , Ana Luiza Pereira de Santana, Vinícius de Lima Valle, Keila Cristiane Batista do Santana , Ytafaella Oliveira Melo , Lívia Fernanda Sousa de Suwa, Daniel Pereira Pio Sampaio , Alexandre Felipe Bastos Barbosa , Helcio Cavalcante |
author_role |
author |
author2 |
Gama, Keit Maciel da Santos , Álvaro Sanataniel Pereira dos Coelho, Nicole Mendonça Fernandes Aguiar , Ana Luiza Pereira de Santana, Vinícius de Lima Valle, Keila Cristiane Batista do Santana , Ytafaella Oliveira Melo , Lívia Fernanda Sousa de Suwa, Daniel Pereira Pio Sampaio , Alexandre Felipe Bastos Barbosa , Helcio Cavalcante |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cunha, Ítalo Íris Boiba Rodrigues da Gama, Keit Maciel da Santos , Álvaro Sanataniel Pereira dos Coelho, Nicole Mendonça Fernandes Aguiar , Ana Luiza Pereira de Santana, Vinícius de Lima Valle, Keila Cristiane Batista do Santana , Ytafaella Oliveira Melo , Lívia Fernanda Sousa de Suwa, Daniel Pereira Pio Sampaio , Alexandre Felipe Bastos Barbosa , Helcio Cavalcante |
dc.subject.por.fl_str_mv |
Doenças Endócrinas; Mecanismo de ação; Doença de Addison; Tireoidite de Hashimoto; Diabetes tipo I. Endocrine Diseases; Mechanism of action; Addison's disease; Hashimoto's thyroiditis; Diabetes I. |
topic |
Doenças Endócrinas; Mecanismo de ação; Doença de Addison; Tireoidite de Hashimoto; Diabetes tipo I. Endocrine Diseases; Mechanism of action; Addison's disease; Hashimoto's thyroiditis; Diabetes I. |
description |
Immunology emerges as a protagonist in understanding autoimmune diseases of the endocrine system. Autoimmune diseases represent a significant challenge, as they involve an immune response that, instead of protecting the body, is mistakenly directed against its own cells and tissues. In the context of the endocrine system, where hormones play a crucial role in regulating diverse bodily functions, autoimmune manifestations introduce an additional layer of complexity. Objective: This article proposes a comprehensive exploration of endocrine diseases, highlighting not only the physiological foundations but also clinical challenges and therapeutic innovations. Methodology: The research was carried out through online access in the Scientific Electronic Library Online (SCIELO), PubMed, Latin American Caribbean Literature in Health Sciences (LILACS). in the month of January 2024. Analytical reading of the articles with the theme of the theme was carried out, upon reading the articles were subjected to inclusion and exclusion criteria, within the inclusion criteria original articles were considered, which addressed the researched topic and allowed full access to the study content, published between 2015 and 2023, in Portuguese and English. Results and Discussions: The results obtained in this investigation reveal a complex panorama of the interactions between the immune system and autoimmune diseases of the endocrine system. In-depth analysis of the collected samples highlights specific immune response patterns that directly correlate with the manifestation of these pathologies. When examining the data, there is clear evidence of immune dysfunction, reflected in autoimmune responses directed against endocrine glands. The presence of specific markers and changes in molecular profiles supports the hypothesis that the immune system plays a central role in the etiology of these conditions. The discussion of these results contextualizes the findings in the current scientific scenario, comparing them with previous studies and highlighting divergences or convergences. A clearer understanding of the underlying immunological mechanisms allows us to speculate on possible therapeutic strategies. Conclusion: Challenging immunology proves to be fundamental for understanding autoimmune diseases that affect the endocrine system. By exploring in depth, the complex interactions between the immune system and endocrine glands, this study contributes significantly to the understanding of these pathologies. The results clearly demonstrate the preponderant influence of the immune system on the manifestations of these diseases, suggesting promising therapeutic targets. Meticulous data analysis highlights consistent patterns of autoimmune response, providing valuable insights for future investigations and clinical interventions. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1430 10.36557/2674-8169.2024v6n2p724-745 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1430 |
identifier_str_mv |
10.36557/2674-8169.2024v6n2p724-745 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1430/1611 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 724-745 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 724-745 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 724-745 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798444426231808 |