Relationship of gut microbiota with obesity in women during menopause

• Autor(a) principal: Savi, Daiani Cristina
• Data de Publicação: 2024
• Outros Autores: do Nascimento, Joycy Sybely, Oeschsler, Nicole, Hudler Stahn, Sara Victoria
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1708
• topic: Microbiota intestinal; Obesidade; Menopausa

Obesity represents a serious problem and a risk factor for the obese individual, as it triggers the development of non-communicable chronic diseases (NCDs) and other complications. Several factors are associated with weight gain, including lifestyle habits, diet and predisposition. But, in addition, the intestinal microbiota is also strongly related to this process. The intestinal microbiota concerns the colonization of different microorganisms in the intestine region. The regulation and balance of this ensures that metabolism homeostasis occurs. The imbalance associated with weight gain is especially linked to the relationship between the Firmicutes and Bacteroidetes phyla, which are associated with the regulation and homeostasis of energy recovery and caloric expenditure. Menopause also represents an important factor in the development of obesity. The drop in estrogen levels favors the accumulation of fat and overweight, due to the shift of fat accumulation to the abdominal region and influencing resistance to leptin. Thus, there is an association between these three factors, so that the alteration in the microbiota is capable of influencing the regulation of energy balance and estrogen deconjugation. Furthermore, the use of pre and probiotics has been described as efficient in correcting dysbiosis and minimizing symptoms and inflammatory processes experienced in menopause associated with obesity.