A Relação entre vitamina D materna e o desenvolvimento do transtorno do espectro autista na prole: uma revisão sistemática

• Autor(a) principal: Xavier Oliveira, Káryta Lorrane
• Data de Publicação: 2024
• Outros Autores: Cândida Silva, Anne Pietra, Ferreira de Oliveira, Dyulia, Alcântara Paniago, Filipe de Oliveira, Bernardi Torres, Gloria, Rodrigues Lobo, Isabella, Vigilato Vital, Mabio, Rocha Andrade, Maria Clara, Souza Godoy Freitas, Maria Eduarda, Vasconcellos de Oliveira, Mariana, Cardoso Silva , Matheus, Dhieggo Amaral, Rhaygner
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1418
• topic: Transtorno do Espectro Autista; Vitamina D; Prevenção de doenças; Gravidez.

Introduction: Autism spectrum disorder (ASD) manifests itself, for the most part, in childhood, therefore, there is a great effort by researchers to design a way to prevent autism, especially on interventions carried out during pregnancy. Therefore, the objective of the present study is to outline the way in which maternal vitamin D can prevent the occurrence of autism during fetal development, elucidating the effectiveness of preventing autism through maternal vitamin D supplementation. Methodology: Treats This was a systematic review with a time frame from 2015 to 2023, in the Pubmed, Scielo, Medline, Lilacs, Google Schoolar and Cochrane Library databases. After critical evaluation related to the inclusion and exclusion criteria, 13 articles were selected and the systematic review was carried out according to the standards proposed by PRISMA. RESULTS: a significant number of VDRs were found in the cortex and hippocampus, regions strictly related to learning, memory and executive control. Lower maternal serum levels of 25-(OH)D, more specifically in the first trimester, are associated with a significantly increased risk of developing ASD in the offspring. Discussion: There is a need to standardize the bioanalytical determination methods used to assess vitamin D status and the neuropsychiatric assessment of study subjects in order to find a relationship between vitamin D deficiency and cognitive impairments. Conclusion: Most of the studies analyzed showed that maternal Vitamin D supplementation resulted in a reduction in the incidence of ASD in the offspring.