PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW
Main Author: | |
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Publication Date: | 2023 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | por |
Source: | Brazilian Journal of Implantology and Health Sciences |
Download full: | https://bjihs.emnuvens.com.br/bjihs/article/view/708 |
Summary: | Childhood autism is a neurodevelopmental disorder characterized by difficulties in social communication, interaction and repetitive behavior patterns. This study aims to carry out an integrative review of the pharmacological interventions used in the treatment of childhood autism, focusing on current approaches. Understanding these interventions is crucial to optimizing clinical management and improving the quality of life of affected children. An integrative literature review was conducted, searching for scientific articles in indexed databases, using descriptors related to childhood autism and pharmacological interventions. Studies investigating the use of drugs in the treatment of autism were included, focusing on recent and relevant approaches. The references were analyzed and organized according to the Vancouver style. Several pharmacological interventions used in the treatment of childhood autism were identified, with methylphenidate and cannabinoids standing out. These have shown positive effects in improving symptoms related to attention and hyperactivity. In addition, studies have pointed to pathophysiological changes, such as immunoregulation, inflammation, oxidative stress and mitochondrial dysfunction, which may offer additional therapeutic targets for future approaches. The integrative review demonstrates the diversity of pharmacological interventions available for the treatment of childhood autism, highlighting the need for a personalized and interdisciplinary approach. The individualization of treatment, taking into account individual characteristics and clinical peculiarities, is fundamental. In addition, the long-term safety and efficacy of pharmacological interventions must be carefully monitored. This study contributes to the current understanding of pharmacological therapeutic options and offers insights for future research in this field. |
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PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEWPERSPECTIVAS FARMACOLÓGICAS NO TRATAMENTO DO AUTISMO INFANTIL: UMA REVISÃO INTEGRATIVATranstorno do Espectro AutistaTratamento FarmacológicoCriançaMetilfenidatoCanabinóidesEstresse OxidativoAutism Spectrum Disorder, Pharmacological Treatment, Child, Methylphenidate, Cannabinoids, Oxidative Stress.Childhood autism is a neurodevelopmental disorder characterized by difficulties in social communication, interaction and repetitive behavior patterns. This study aims to carry out an integrative review of the pharmacological interventions used in the treatment of childhood autism, focusing on current approaches. Understanding these interventions is crucial to optimizing clinical management and improving the quality of life of affected children. An integrative literature review was conducted, searching for scientific articles in indexed databases, using descriptors related to childhood autism and pharmacological interventions. Studies investigating the use of drugs in the treatment of autism were included, focusing on recent and relevant approaches. The references were analyzed and organized according to the Vancouver style. Several pharmacological interventions used in the treatment of childhood autism were identified, with methylphenidate and cannabinoids standing out. These have shown positive effects in improving symptoms related to attention and hyperactivity. In addition, studies have pointed to pathophysiological changes, such as immunoregulation, inflammation, oxidative stress and mitochondrial dysfunction, which may offer additional therapeutic targets for future approaches. The integrative review demonstrates the diversity of pharmacological interventions available for the treatment of childhood autism, highlighting the need for a personalized and interdisciplinary approach. The individualization of treatment, taking into account individual characteristics and clinical peculiarities, is fundamental. In addition, the long-term safety and efficacy of pharmacological interventions must be carefully monitored. This study contributes to the current understanding of pharmacological therapeutic options and offers insights for future research in this field.O autismo infantil é um transtorno do neurodesenvolvimento caracterizado por dificuldades na comunicação social, interação e padrões de comportamento repetitivos. O presente estudo visa realizar uma revisão integrativa das intervenções farmacológicas utilizadas no tratamento do autismo infantil, com foco nas abordagens atuais. O entendimento dessas intervenções é crucial para otimizar o manejo clínico e melhorar a qualidade de vida das crianças afetadas. Foi conduzida uma revisão integrativa da literatura, com a busca de artigos científicos nas bases de dados indexadas, utilizando descritores relacionados ao autismo infantil e intervenções farmacológicas. Foram incluídos estudos que investigaram o uso de fármacos no tratamento do autismo, com foco em abordagens recentes e relevantes. As referências foram analisadas e organizadas conforme o estilo de Vancouver. Foram identificadas diversas intervenções farmacológicas utilizadas no tratamento do autismo infantil, com destaque para o metilfenidato e os canabinóides. Estes mostraram efeitos positivos na melhoria dos sintomas relacionados à atenção e hiperatividade. Além disso, estudos apontaram para alterações fisiopatológicas, como imunorregulação, inflamação, estresse oxidativo e disfunção mitocondrial, que podem oferecer alvos terapêuticos adicionais para abordagens futuras. A revisão integrativa demonstra a diversidade de intervenções farmacológicas disponíveis para o tratamento do autismo infantil, evidenciando a necessidade de uma abordagem personalizada e interdisciplinar. A individualização do tratamento, considerando características individuais e peculiaridades clínicas, é fundamental. Além disso, a segurança e eficácia a longo prazo das intervenções farmacológicas devem ser cuidadosamente monitoradas. Este estudo contribui para o entendimento atual das opções terapêuticas farmacológicas e oferece insights para futuras pesquisas nesse campo.Specialized Dentistry Group2023-10-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/70810.36557/2674-8169.2023v5n4p1567-1576Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 4 (2023): BJIHS QUALIS B3; 1567-1576Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 4 (2023): BJIHS QUALIS B3; 1567-1576Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 4 (2023): BJIHS QUALIS B3; 1567-15762674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/708/862Copyright (c) 2023 Giovanna Pauletti de Castro, Emanuel Campos Menezes, Gabriela Gabriela , Marina Maria Alencar Pinto Rocha, Ana Flávia Prado de Oliveira, Bianca Santana, Isadora Cristina Teixeira Bono , Edilson Lucas do Amaral Neto , Danielle Beltrão Araujo Mendes Amorimhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPauletti de Castro, GiovannaCampos Menezes, EmanuelCordeiro da Silva, Gabriela Alencar Pinto Rocha, Marina MariaPrado de Oliveira, Ana FláviaSantana, Bianca Teixeira Bono , Isadora Cristina do Amaral Neto , Edilson Lucas Araujo Mendes Amorim, Danielle Beltrão2023-10-23T17:01:25Zoai:ojs.bjihs.emnuvens.com.br:article/708Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2023-10-23T17:01:25Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW PERSPECTIVAS FARMACOLÓGICAS NO TRATAMENTO DO AUTISMO INFANTIL: UMA REVISÃO INTEGRATIVA |
title |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW |
spellingShingle |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW Pauletti de Castro, Giovanna Transtorno do Espectro Autista Tratamento Farmacológico Criança Metilfenidato Canabinóides Estresse Oxidativo Autism Spectrum Disorder, Pharmacological Treatment, Child, Methylphenidate, Cannabinoids, Oxidative Stress. |
title_short |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW |
title_full |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW |
title_fullStr |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW |
title_full_unstemmed |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW |
title_sort |
PHARMACOLOGICAL PERSPECTIVES IN THE TREATMENT OF CHILDHOOD AUTISM: AN INTEGRATIVE REVIEW |
author |
Pauletti de Castro, Giovanna |
author_facet |
Pauletti de Castro, Giovanna Campos Menezes, Emanuel Cordeiro da Silva, Gabriela Alencar Pinto Rocha, Marina Maria Prado de Oliveira, Ana Flávia Santana, Bianca Teixeira Bono , Isadora Cristina do Amaral Neto , Edilson Lucas Araujo Mendes Amorim, Danielle Beltrão |
author_role |
author |
author2 |
Campos Menezes, Emanuel Cordeiro da Silva, Gabriela Alencar Pinto Rocha, Marina Maria Prado de Oliveira, Ana Flávia Santana, Bianca Teixeira Bono , Isadora Cristina do Amaral Neto , Edilson Lucas Araujo Mendes Amorim, Danielle Beltrão |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pauletti de Castro, Giovanna Campos Menezes, Emanuel Cordeiro da Silva, Gabriela Alencar Pinto Rocha, Marina Maria Prado de Oliveira, Ana Flávia Santana, Bianca Teixeira Bono , Isadora Cristina do Amaral Neto , Edilson Lucas Araujo Mendes Amorim, Danielle Beltrão |
dc.subject.por.fl_str_mv |
Transtorno do Espectro Autista Tratamento Farmacológico Criança Metilfenidato Canabinóides Estresse Oxidativo Autism Spectrum Disorder, Pharmacological Treatment, Child, Methylphenidate, Cannabinoids, Oxidative Stress. |
topic |
Transtorno do Espectro Autista Tratamento Farmacológico Criança Metilfenidato Canabinóides Estresse Oxidativo Autism Spectrum Disorder, Pharmacological Treatment, Child, Methylphenidate, Cannabinoids, Oxidative Stress. |
description |
Childhood autism is a neurodevelopmental disorder characterized by difficulties in social communication, interaction and repetitive behavior patterns. This study aims to carry out an integrative review of the pharmacological interventions used in the treatment of childhood autism, focusing on current approaches. Understanding these interventions is crucial to optimizing clinical management and improving the quality of life of affected children. An integrative literature review was conducted, searching for scientific articles in indexed databases, using descriptors related to childhood autism and pharmacological interventions. Studies investigating the use of drugs in the treatment of autism were included, focusing on recent and relevant approaches. The references were analyzed and organized according to the Vancouver style. Several pharmacological interventions used in the treatment of childhood autism were identified, with methylphenidate and cannabinoids standing out. These have shown positive effects in improving symptoms related to attention and hyperactivity. In addition, studies have pointed to pathophysiological changes, such as immunoregulation, inflammation, oxidative stress and mitochondrial dysfunction, which may offer additional therapeutic targets for future approaches. The integrative review demonstrates the diversity of pharmacological interventions available for the treatment of childhood autism, highlighting the need for a personalized and interdisciplinary approach. The individualization of treatment, taking into account individual characteristics and clinical peculiarities, is fundamental. In addition, the long-term safety and efficacy of pharmacological interventions must be carefully monitored. This study contributes to the current understanding of pharmacological therapeutic options and offers insights for future research in this field. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/708 10.36557/2674-8169.2023v5n4p1567-1576 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/708 |
identifier_str_mv |
10.36557/2674-8169.2023v5n4p1567-1576 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/708/862 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 4 (2023): BJIHS QUALIS B3; 1567-1576 Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 4 (2023): BJIHS QUALIS B3; 1567-1576 Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 4 (2023): BJIHS QUALIS B3; 1567-1576 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798440176353280 |