EPIDEMIOLOGIC AND SPATIAL CHARACTERISTICS OF SICKLE CELL DISEASE AMONG CHILDREN IN THE STATE OF ESPIRITO SANTO, BRAZIL

• Autor(a) principal: Bruzeguini, Meirielli
• Data de Publicação: 2021
• Outros Autores: Furieri, Lorena Barros, Viana, Maria Carmen, Zandonade, Eliana
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Baiana de Saúde Pública (Online)
• Texto Completo: https://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/2957
• topic: Anemia falciforme; Mortalidade; Registros de mortalidade; Triagem neonatal; Atestado de óbito; DOENÇA FALCIFORME; TRIAGEM NEONATAL; ÓBITOS; Anemia de células falciformes; Mortalidad; Registros de mortalidad; Tamizaje neonatal; Certificado de defunción; Sickle cell disease; Mortality; Mortality registries; Neonatal screening; Death certificates

This epidemiological study analyzes the causes and statistics of deaths for sickle cell disease (SCD) among live births (LB) in the state of Espírito Santo, Brazil, between 2001 and 2013. The study examined secondary data from the Brazilian Information Systems of Mortality (SIM), the Neonatal Screening Program of Espírito Santo (PTN/ES) and the Live Birth Information System (SINASC). The database recorded 649.187 live births, from which 86.3% were tested by PTN. Among the infants tested, 339 were positive for SCD, accounting for 60.5/100.000 live births. Amid this number, 59.3% presented genotype HbFS and 29.2% HbFSC. 31 deaths were identified at SIM, 83.9% due to SCD and 16.1% were not considered SCD, although they had been diagnosed with SCD by PTN. The total mortality rate due to SCD was of 4.8/100.000 infants, which is 6 times higher among children not tested by PTN when compared with those who were tested, with rates of 14.6/100.000 and 3.2/100.000, respectively. The highest incidences of mortality were recorded in the metropolitan and coast areas of the state, where 64.5% were boys and 58.1% were aged 1 to 5. Although PTN/ES coverage is considered greater than the national average, a gap of about 14% was found in the SCD screening, with a higher mortality rate amid children not tested. Such findings emphasize the importance of neonatal screening to improve the survival of those affected by SCD.