Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Franco Filho, Luciano Chaves
Data de Publicação: 2023
Outros Autores: Barata, Rafael Ribeiro, Coelho, Mônica Silva, Cardoso, Jedson Ferreira, Lemos, Poliana da Silva, Reis, Herald Souza dos, Favacho, Joana da Felicidade Ribeiro, Faria, Nuno Rodrigues, Nunes, Márcio Roberto Teixeira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/6728
Resumo: The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the region
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spelling Franco Filho, Luciano ChavesBarata, Rafael RibeiroCoelho, Mônica SilvaCardoso, Jedson FerreiraLemos, Poliana da SilvaReis, Herald Souza dosFavacho, Joana da Felicidade RibeiroFaria, Nuno RodriguesNunes, Márcio Roberto Teixeira2023-03-09T14:07:11Z2023-03-09T14:07:11Z2023FRANCO FILHO, Luciano Chaves et al. Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon. Infection, Genetics and Evolution, v. 109, n. 105407, p. 1-5, Apr. 2023. DOI: https://doi.org/10.1016/j.meegid.2023.1567-1348https://patua.iec.gov.br/handle/iec/672810.1016/j.meegid.2023The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the regionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - grant number 3274/2013) and National Council for Scientific and Technological Development (CNPq - grant number 302584/2015-3). NRF was supported by a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (204311/Z/16/Z) and by a Medical Research Council-São Paulo Research Foundation (FAPESP) CADDE partnership award (MR/S0195/1 and FAPESP 18/14389-0)Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of São Paulo. Faculty of Public Health. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of Oxford. Department of Zoology. Oxford, UK.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. 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dc.title.pt_BR.fl_str_mv Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
title Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
spellingShingle Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
Franco Filho, Luciano Chaves
Vírus da Dengue / patogenicidade
Dengue / transmissão
Quirópteros / anatomia & histologia
Tropismo Viral
Sequenciamento de Nucleotídeos em Larga Escala / métodos
Infecções por Arbovirus
title_short Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
title_full Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
title_fullStr Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
title_full_unstemmed Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
title_sort Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
author Franco Filho, Luciano Chaves
author_facet Franco Filho, Luciano Chaves
Barata, Rafael Ribeiro
Coelho, Mônica Silva
Cardoso, Jedson Ferreira
Lemos, Poliana da Silva
Reis, Herald Souza dos
Favacho, Joana da Felicidade Ribeiro
Faria, Nuno Rodrigues
Nunes, Márcio Roberto Teixeira
author_role author
author2 Barata, Rafael Ribeiro
Coelho, Mônica Silva
Cardoso, Jedson Ferreira
Lemos, Poliana da Silva
Reis, Herald Souza dos
Favacho, Joana da Felicidade Ribeiro
Faria, Nuno Rodrigues
Nunes, Márcio Roberto Teixeira
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Franco Filho, Luciano Chaves
Barata, Rafael Ribeiro
Coelho, Mônica Silva
Cardoso, Jedson Ferreira
Lemos, Poliana da Silva
Reis, Herald Souza dos
Favacho, Joana da Felicidade Ribeiro
Faria, Nuno Rodrigues
Nunes, Márcio Roberto Teixeira
dc.subject.decsPrimary.pt_BR.fl_str_mv Vírus da Dengue / patogenicidade
Dengue / transmissão
Quirópteros / anatomia & histologia
Tropismo Viral
Sequenciamento de Nucleotídeos em Larga Escala / métodos
Infecções por Arbovirus
topic Vírus da Dengue / patogenicidade
Dengue / transmissão
Quirópteros / anatomia & histologia
Tropismo Viral
Sequenciamento de Nucleotídeos em Larga Escala / métodos
Infecções por Arbovirus
description The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the region
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-09T14:07:11Z
dc.date.available.fl_str_mv 2023-03-09T14:07:11Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FRANCO FILHO, Luciano Chaves et al. Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon. Infection, Genetics and Evolution, v. 109, n. 105407, p. 1-5, Apr. 2023. DOI: https://doi.org/10.1016/j.meegid.2023.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/6728
dc.identifier.issn.-.fl_str_mv 1567-1348
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.meegid.2023
identifier_str_mv FRANCO FILHO, Luciano Chaves et al. Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon. Infection, Genetics and Evolution, v. 109, n. 105407, p. 1-5, Apr. 2023. DOI: https://doi.org/10.1016/j.meegid.2023.
1567-1348
10.1016/j.meegid.2023
url https://patua.iec.gov.br/handle/iec/6728
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Elsevier
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