Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

Detalhes bibliográficos
Autor(a) principal: Cavalcante, José Roosevelt
Data de Publicação: 2018
Outros Autores: Pinheiro, Luiz Gonzaga Porto, Almeida, Paulo Roberto Carvalho de, Ferreira, Márcia Valéria Pitombeira, Cruz, Gizele Almada, Campelo, Thales Alves, Silva, Caroliny Soares, Lima, Luana Nepomuceno Gondim Costa, Oliveira, Bruno Masato Kitagawa de, Lima, Lara Mulato, Feitosa, Laura Magda Costa, Pinheiro, Agostinho Câmara, Frota, Cristiane Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/3525
Resumo: OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. RESULTS: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. CONCLUSIONS: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.
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spelling Cavalcante, José RooseveltPinheiro, Luiz Gonzaga PortoAlmeida, Paulo Roberto Carvalho deFerreira, Márcia Valéria PitombeiraCruz, Gizele AlmadaCampelo, Thales AlvesSilva, Caroliny SoaresLima, Luana Nepomuceno Gondim CostaOliveira, Bruno Masato Kitagawa deLima, Lara MulatoFeitosa, Laura Magda CostaPinheiro, Agostinho CâmaraFrota, Cristiane Cunha2018-11-13T13:30:35Z2018-11-13T13:30:35Z2018CAVALCANTE, José Roosevelt et al. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence. Clinics, v. 73, e465, p. 1-6, Oct. 2018.1807-5932https://patua.iec.gov.br/handle/iec/352510.6061/clinics/2018/e465OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. RESULTS: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. CONCLUSIONS: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Cirurgia e Maternidade Escola Assis Chateaubriand. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil.Universidade Federal Ceará. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.engFaculdade de Medicina / USPAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidenceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePapillomaviridae / patogenicidadeInfecções por Papillomavirus / patogenicidadePapillomavirus Humano 11 / isolamento & purificaçãoPapillomavirus Humano 6 / isolamento & purificaçãoNeoplasias da MamaCarcinogênese / patologiaCoinfecçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.pdfAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.pdfapplication/pdf575259https://patua.iec.gov.br/bitstreams/6c4f1db9-3e74-4dc2-ba3a-ff3ef74c9d3a/downloadc1dd29d7571d02d8c100712d9ca25182MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/89abad8f-3482-4386-b1ce-22f051719c29/download52f1732ea66fbd1123abe39f5373b797MD52TEXTAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.pdf.txtAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.pdf.txtExtracted texttext/plain41127https://patua.iec.gov.br/bitstreams/bc8df7aa-4af3-4804-91cc-8aa2aa80cdec/downloadcc15af51b853e7a1800b31e1364a43f7MD55THUMBNAILAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.pdf.jpgAssociation of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence.pdf.jpgGenerated Thumbnailimage/jpeg7200https://patua.iec.gov.br/bitstreams/98cdfd68-d3f1-467d-b739-a0848cfb4a72/download992cf4eba8783042d0bd2152d7954c35MD56iec/35252022-10-20 22:22:20.321oai:patua.iec.gov.br:iec/3525https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:22:20Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
spellingShingle Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
Cavalcante, José Roosevelt
Papillomaviridae / patogenicidade
Infecções por Papillomavirus / patogenicidade
Papillomavirus Humano 11 / isolamento & purificação
Papillomavirus Humano 6 / isolamento & purificação
Neoplasias da Mama
Carcinogênese / patologia
Coinfecção
title_short Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_full Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_fullStr Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_full_unstemmed Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
title_sort Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
author Cavalcante, José Roosevelt
author_facet Cavalcante, José Roosevelt
Pinheiro, Luiz Gonzaga Porto
Almeida, Paulo Roberto Carvalho de
Ferreira, Márcia Valéria Pitombeira
Cruz, Gizele Almada
Campelo, Thales Alves
Silva, Caroliny Soares
Lima, Luana Nepomuceno Gondim Costa
Oliveira, Bruno Masato Kitagawa de
Lima, Lara Mulato
Feitosa, Laura Magda Costa
Pinheiro, Agostinho Câmara
Frota, Cristiane Cunha
author_role author
author2 Pinheiro, Luiz Gonzaga Porto
Almeida, Paulo Roberto Carvalho de
Ferreira, Márcia Valéria Pitombeira
Cruz, Gizele Almada
Campelo, Thales Alves
Silva, Caroliny Soares
Lima, Luana Nepomuceno Gondim Costa
Oliveira, Bruno Masato Kitagawa de
Lima, Lara Mulato
Feitosa, Laura Magda Costa
Pinheiro, Agostinho Câmara
Frota, Cristiane Cunha
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cavalcante, José Roosevelt
Pinheiro, Luiz Gonzaga Porto
Almeida, Paulo Roberto Carvalho de
Ferreira, Márcia Valéria Pitombeira
Cruz, Gizele Almada
Campelo, Thales Alves
Silva, Caroliny Soares
Lima, Luana Nepomuceno Gondim Costa
Oliveira, Bruno Masato Kitagawa de
Lima, Lara Mulato
Feitosa, Laura Magda Costa
Pinheiro, Agostinho Câmara
Frota, Cristiane Cunha
dc.subject.decsPrimary.pt_BR.fl_str_mv Papillomaviridae / patogenicidade
Infecções por Papillomavirus / patogenicidade
Papillomavirus Humano 11 / isolamento & purificação
Papillomavirus Humano 6 / isolamento & purificação
Neoplasias da Mama
Carcinogênese / patologia
Coinfecção
topic Papillomaviridae / patogenicidade
Infecções por Papillomavirus / patogenicidade
Papillomavirus Humano 11 / isolamento & purificação
Papillomavirus Humano 6 / isolamento & purificação
Neoplasias da Mama
Carcinogênese / patologia
Coinfecção
description OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region. RESULTS: Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples. CONCLUSIONS: The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-11-13T13:30:35Z
dc.date.available.fl_str_mv 2018-11-13T13:30:35Z
dc.date.issued.fl_str_mv 2018
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dc.identifier.citation.fl_str_mv CAVALCANTE, José Roosevelt et al. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence. Clinics, v. 73, e465, p. 1-6, Oct. 2018.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3525
dc.identifier.issn.-.fl_str_mv 1807-5932
dc.identifier.doi.-.fl_str_mv 10.6061/clinics/2018/e465
identifier_str_mv CAVALCANTE, José Roosevelt et al. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence. Clinics, v. 73, e465, p. 1-6, Oct. 2018.
1807-5932
10.6061/clinics/2018/e465
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