Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2872 |
Resumo: | American cutaneous leishmaniasis (ACL) is a chronic infectious disease caused by different protozoan species of Leishmania, and it is endemic in both tropical and subtropical countries. Using immunohistochemistry, we investigate the density of CD68+, lysozyme+, CD1a+, factor XIIIa+, CD4+, CD8+, CD56+, interferon (IFN)-γ+, and inducible NO synthase (iNOS+) cells. These cells were analyzed from 22 biopsy samples obtained from the lesions of ACL patients, whose infection was caused by Leishmania (Viannia) spp. Histopathological analysis showed dense mononuclear inflammatory infiltration in the dermis, which was composed of lymphocytes, macrophages, plasma cells, and discrete tissue parasitism. Granulomatous reactions were also present in the majority of cases. The density of the activated macrophages was higher than that of inactivated macrophages in the lesions. The density of Langerhans cells (CD1a+) was lower than that of dermal dendrocytes (factor XIIIa+). The density of CD8+ T lymphocytes was higher than that of CD4+ T lymphocytes. The cellular density of these immunological markers in relation to the species of Leishmania demonstrated that L. (Viannia) sp. lesions had higher IFN-γ expression than that Leishmania (Viania) braziliensis lesions. The evaluation of these markers, according to disease progression, did not reveal any significant differences. L. (Viannia) sp. infection leads to a favorable immune response in the host, as predominantly represented by lysozyme+, factor XIIIa+, CD8+ T cells, and the expression of (IFN)-γ+ at the lesion site. |
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Gomes, Claudia Maria de CastroSousa, Maria Gloria TeixeiraMenezes, Joyce Prieto BezerraBatista, Marliane BatistaLima, Ana Carolina StoccoBelda Jr, WalterBradshaw, DanielGama, Monica Elinor AlvesLaurenti, Márcia DalastraSilveira, Fernando TobiasCorbett, Carlos Eduardo Pereira2017-11-23T12:05:33Z2017-11-23T12:05:33Z2017GOMES, Cláudia Maria de Castro et al. Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil. Parasitology Research, v. 116, n. 5, p. 1423-1431, May 2017. DOI: https://doi.org/10.1007/s00436-017-5403-40932-0113https://patua.iec.gov.br/handle/iec/287210.1007/s00436-017-5403-4American cutaneous leishmaniasis (ACL) is a chronic infectious disease caused by different protozoan species of Leishmania, and it is endemic in both tropical and subtropical countries. Using immunohistochemistry, we investigate the density of CD68+, lysozyme+, CD1a+, factor XIIIa+, CD4+, CD8+, CD56+, interferon (IFN)-γ+, and inducible NO synthase (iNOS+) cells. These cells were analyzed from 22 biopsy samples obtained from the lesions of ACL patients, whose infection was caused by Leishmania (Viannia) spp. Histopathological analysis showed dense mononuclear inflammatory infiltration in the dermis, which was composed of lymphocytes, macrophages, plasma cells, and discrete tissue parasitism. Granulomatous reactions were also present in the majority of cases. The density of the activated macrophages was higher than that of inactivated macrophages in the lesions. The density of Langerhans cells (CD1a+) was lower than that of dermal dendrocytes (factor XIIIa+). The density of CD8+ T lymphocytes was higher than that of CD4+ T lymphocytes. The cellular density of these immunological markers in relation to the species of Leishmania demonstrated that L. (Viannia) sp. lesions had higher IFN-γ expression than that Leishmania (Viania) braziliensis lesions. The evaluation of these markers, according to disease progression, did not reveal any significant differences. L. (Viannia) sp. infection leads to a favorable immune response in the host, as predominantly represented by lysozyme+, factor XIIIa+, CD8+ T cells, and the expression of (IFN)-γ+ at the lesion site.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.São Paulo University. Medical School. Dermatology Department. São Paulo, SP, Brazil.Chelsea and Westminster Hospital London. London, UK.Federal University of Maranhão. Pediatric Department. São Luis, MA, Brazil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Federal University of Pará. Tropical Medicine Institute. Belém, PA, Brazil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.engSpringer VerlagImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmania / imunologiaLeishmania braziliensis / imunologiaLeishmaniose Cutânea / imunologiaLeishmaniose Cutânea / parasitologiaCélulas de Langerhans / citologiaCélulas de Langerhans / imunologiaLinfócitos T CD4-positivos / imunologiaLinfócitos T CD8-Positivos / citologiaLinfócitos T CD8-positivos / imunologiaDerme / parasitologiaDerme / patologiaFator XIIIa / metabolismoInterferon gama / metabolismoMacrófagos / imunologiaAtivação de Macrófagos / imunologiaImuno-Histoquímica / métodosReação em Cadeia da Polimerase / métodosinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/2baaf6c4-a10f-478f-bb0c-8060872f50ea/download52f1732ea66fbd1123abe39f5373b797MD52ORIGINALImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.pdfImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.pdfapplication/pdf174567https://patua.iec.gov.br/bitstreams/4d165876-63fc-4094-8d15-2df18a83fd4f/download82eb0120385ccc9d933cec69c887fd8dMD53TEXTImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.pdf.txtImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.pdf.txtExtracted texttext/plain3427https://patua.iec.gov.br/bitstreams/f5ef6193-f52a-4646-996b-ef1e39b75e78/downloadb5433f63e1de503f8974e8b3f697ebe9MD56THUMBNAILImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.pdf.jpgImmunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5132https://patua.iec.gov.br/bitstreams/f765aee6-6368-4172-97b5-f38240cc111f/downloadb0dee2d2fa3622f9bf40d88c778b95e5MD57iec/28722023-06-13 14:32:47.102oai:patua.iec.gov.br:iec/2872https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-06-13T14:32:47Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
title |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
spellingShingle |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil Gomes, Claudia Maria de Castro Leishmania / imunologia Leishmania braziliensis / imunologia Leishmaniose Cutânea / imunologia Leishmaniose Cutânea / parasitologia Células de Langerhans / citologia Células de Langerhans / imunologia Linfócitos T CD4-positivos / imunologia Linfócitos T CD8-Positivos / citologia Linfócitos T CD8-positivos / imunologia Derme / parasitologia Derme / patologia Fator XIIIa / metabolismo Interferon gama / metabolismo Macrófagos / imunologia Ativação de Macrófagos / imunologia Imuno-Histoquímica / métodos Reação em Cadeia da Polimerase / métodos |
title_short |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
title_full |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
title_fullStr |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
title_full_unstemmed |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
title_sort |
Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil |
author |
Gomes, Claudia Maria de Castro |
author_facet |
Gomes, Claudia Maria de Castro Sousa, Maria Gloria Teixeira Menezes, Joyce Prieto Bezerra Batista, Marliane Batista Lima, Ana Carolina Stocco Belda Jr, Walter Bradshaw, Daniel Gama, Monica Elinor Alves Laurenti, Márcia Dalastra Silveira, Fernando Tobias Corbett, Carlos Eduardo Pereira |
author_role |
author |
author2 |
Sousa, Maria Gloria Teixeira Menezes, Joyce Prieto Bezerra Batista, Marliane Batista Lima, Ana Carolina Stocco Belda Jr, Walter Bradshaw, Daniel Gama, Monica Elinor Alves Laurenti, Márcia Dalastra Silveira, Fernando Tobias Corbett, Carlos Eduardo Pereira |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Claudia Maria de Castro Sousa, Maria Gloria Teixeira Menezes, Joyce Prieto Bezerra Batista, Marliane Batista Lima, Ana Carolina Stocco Belda Jr, Walter Bradshaw, Daniel Gama, Monica Elinor Alves Laurenti, Márcia Dalastra Silveira, Fernando Tobias Corbett, Carlos Eduardo Pereira |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmania / imunologia Leishmania braziliensis / imunologia Leishmaniose Cutânea / imunologia Leishmaniose Cutânea / parasitologia Células de Langerhans / citologia Células de Langerhans / imunologia Linfócitos T CD4-positivos / imunologia Linfócitos T CD8-Positivos / citologia Linfócitos T CD8-positivos / imunologia Derme / parasitologia Derme / patologia Fator XIIIa / metabolismo Interferon gama / metabolismo Macrófagos / imunologia Ativação de Macrófagos / imunologia Imuno-Histoquímica / métodos Reação em Cadeia da Polimerase / métodos |
topic |
Leishmania / imunologia Leishmania braziliensis / imunologia Leishmaniose Cutânea / imunologia Leishmaniose Cutânea / parasitologia Células de Langerhans / citologia Células de Langerhans / imunologia Linfócitos T CD4-positivos / imunologia Linfócitos T CD8-Positivos / citologia Linfócitos T CD8-positivos / imunologia Derme / parasitologia Derme / patologia Fator XIIIa / metabolismo Interferon gama / metabolismo Macrófagos / imunologia Ativação de Macrófagos / imunologia Imuno-Histoquímica / métodos Reação em Cadeia da Polimerase / métodos |
description |
American cutaneous leishmaniasis (ACL) is a chronic infectious disease caused by different protozoan species of Leishmania, and it is endemic in both tropical and subtropical countries. Using immunohistochemistry, we investigate the density of CD68+, lysozyme+, CD1a+, factor XIIIa+, CD4+, CD8+, CD56+, interferon (IFN)-γ+, and inducible NO synthase (iNOS+) cells. These cells were analyzed from 22 biopsy samples obtained from the lesions of ACL patients, whose infection was caused by Leishmania (Viannia) spp. Histopathological analysis showed dense mononuclear inflammatory infiltration in the dermis, which was composed of lymphocytes, macrophages, plasma cells, and discrete tissue parasitism. Granulomatous reactions were also present in the majority of cases. The density of the activated macrophages was higher than that of inactivated macrophages in the lesions. The density of Langerhans cells (CD1a+) was lower than that of dermal dendrocytes (factor XIIIa+). The density of CD8+ T lymphocytes was higher than that of CD4+ T lymphocytes. The cellular density of these immunological markers in relation to the species of Leishmania demonstrated that L. (Viannia) sp. lesions had higher IFN-γ expression than that Leishmania (Viania) braziliensis lesions. The evaluation of these markers, according to disease progression, did not reveal any significant differences. L. (Viannia) sp. infection leads to a favorable immune response in the host, as predominantly represented by lysozyme+, factor XIIIa+, CD8+ T cells, and the expression of (IFN)-γ+ at the lesion site. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-11-23T12:05:33Z |
dc.date.available.fl_str_mv |
2017-11-23T12:05:33Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, Cláudia Maria de Castro et al. Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil. Parasitology Research, v. 116, n. 5, p. 1423-1431, May 2017. DOI: https://doi.org/10.1007/s00436-017-5403-4 |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2872 |
dc.identifier.issn.-.fl_str_mv |
0932-0113 |
dc.identifier.doi.-.fl_str_mv |
10.1007/s00436-017-5403-4 |
identifier_str_mv |
GOMES, Cláudia Maria de Castro et al. Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil. Parasitology Research, v. 116, n. 5, p. 1423-1431, May 2017. DOI: https://doi.org/10.1007/s00436-017-5403-4 0932-0113 10.1007/s00436-017-5403-4 |
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https://patua.iec.gov.br/handle/iec/2872 |
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eng |
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eng |
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Springer Verlag |
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Springer Verlag |
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