A novel hepacivirus in wild rodents from South America
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3633 |
Resumo: | The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus. |
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Souza, William Marciel deFumagalli, Marcílio JorgeSantos Jr, Gilberto SabinoMaia, Felipe Gonçalves MottaModha, SejalNunes, Márcio Roberto TeixeiraMurcia, Pablo RamiroFigueiredo, Luiz Tadeu Moraes2019-04-09T16:10:03Z2019-04-09T16:10:03Z2019SOUZA, William Marciel de et al. A novel hepacivirus in wild rodents from South America. Viruses. v. 11, n. 3, e297, p. 1-7, Mar. 2019.1999-4915https://patua.iec.gov.br/handle/iec/363310.3390/v11030297The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.This research was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant number No. 13/14929-1, and Scholarships No. 12/24150-9; 15/05778-5; 17/13981-0; 16/01414-1; 08/06411-4; 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9).University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil / MRC-University of Glasgow Centre for Virus Research. Glasgow, UK / University of Campinas. Institute of Biology. Department of Genetics, Evolution and Bioagents. Campinas, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil / University of São Paulo. Institute of Biomedical Sciences. São Paulo, SP, Brazil.MRC-University of Glasgow Centre for Virus Research. Glasgow, UK.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro de Inovações Tecnológicas.Ananindeua, PA, Brasil.MRC-University of Glasgow Centre for Virus Research. Glasgow, UK.University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.engMDPIA novel hepacivirus in wild rodents from South Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHepacivirus / isolamento & purificaçãoHepatite C / patologiaFlaviviridae / patogenicidadeArvicolinae / virologiaCamundongosDoenças dos Roedores / virologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALA novel hepacivirus in wild rodents from South America.pdfA novel hepacivirus in wild rodents from South America.pdfapplication/pdf1480559https://patua.iec.gov.br/bitstreams/3090798c-9095-4092-9ab1-baee375b1328/downloadbcd5d2e4b6f32931038b5350b6211791MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/b07f259f-d3b9-4e55-bcb1-5e1fdc4fd21d/download11832eea31b16df8613079d742d61793MD52TEXTA novel hepacivirus in wild rodents from South America.pdf.txtA novel hepacivirus in wild rodents from South America.pdf.txtExtracted texttext/plain32094https://patua.iec.gov.br/bitstreams/94f47717-6f28-4a87-957f-7237315497fc/downloadfdeef8a5dce777a390cf69aa061d3a88MD55THUMBNAILA novel hepacivirus in wild rodents from South America.pdf.jpgA novel hepacivirus in wild rodents from South America.pdf.jpgGenerated Thumbnailimage/jpeg5329https://patua.iec.gov.br/bitstreams/51381bcd-858d-4e67-82da-d3ef2e554159/download2bae2f9b49bfdf5828ea5821bb940efdMD56iec/36332022-10-20 21:12:14.95oai:patua.iec.gov.br:iec/3633https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:12:14Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falsePGI+TGljZW7Dp2EgZGUgRGlzdHJpYnVpw6fDo28gTsOjbyBFeGNsdXNpdmE8L2I+DQoNClRvZG8gZGVwb3NpdGFudGUgZGUgbWF0ZXJpYWwgbm8gUGF0dcOhIGRldmUgY29uY2VkZXIgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIHVtYSBMaWNlbsOnYSBkZSBEaXN0cmlidWnDp8OjbyBOw6NvIEV4Y2x1c2l2YSBwYXJhIHRvcm5hciBlIG1hbnRlciBhY2Vzc8OtdmVpcyBvcyBzZXVzIGRvY3VtZW50b3MgZW0gZm9ybWF0byBkaWdpdGFsLiANCg0KQ29tIGEgY29uY2Vzc8OjbyBkZXNzYSBsaWNlbsOnYSBuw6NvIGV4Y2x1c2l2YSwgbyBkZXBvc2l0YW50ZSBjb250aW51YSBhIHJldGVyIHRvZG9zIG9zIGRpcmVpdG9zIGRlIGF1dG9yLg0KDQpBbyBhc3NpbmFyIGUgZW50cmVnYXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKQ0KDQphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRlIHNldSBkb2N1bWVudG8uDQoNCmIpIENvbmNlZGUgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIG8gZGlyZWl0byBuw6NvIGV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyIGUvb3UgZGlzdHJpYnVpciBubyA8Yj5QYXR1w6E8L2I+LCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uDQoNCmMpIERlY2xhcmEgcXVlIGF1dG9yaXphIG8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIGEgYXJxdWl2YXIgbWFpcyBkZSB1bWEgY8OzcGlhIGRlc3NlIGRvY3VtZW50byBlIGNvbnZlcnTDqi1sbywgc2VtIGFsdGVyYXIgbyBzZXUgY29udGXDumRvLCBwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgZmljaGVpcm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uDQoNCmQpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCBlIHF1ZSBkZXTDqW0gbyBkaXJlaXRvIGRlIGNvbmNlZGVyIGEgdGVyY2Vpcm9zIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuDQoNCmUpIERlY2xhcmEgcXVlLCBubyBjYXNvIGRvIGRvY3VtZW50byBzdWJtZXRpZG8gY29udGVyIG1hdGVyaWFsIGRvIHF1YWwgbsOjbyBkZXTDqW0gb3MgZGlyZWl0b3MgZGUgYXV0b3IsIG9idGV2ZSBhIGF1dG9yaXphw6fDo28gaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhbyBJbnN0aXR1dG8gRXZhbmRybyBDaGFnYXMgb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIHV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBjb250ZcO6ZG8gZG8gZG9jdW1lbnRvIGVudHJlZ3VlLg0KDQpmKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSBGT1IgQkFTRUFETyBFTSBUUkFCQUxITyBGSU5BTkNJQURPIE9VIEFQT0lBRE8gUE9SIE9VVFJBIElOU1RJVFVJw4fDg08gUVVFIE7Dg08gTyBJTlNUSVRVVE8gRVZBTkRSTyBDSEFHQVMsIERFQ0xBUkEgUVVFIENVTVBSSVUgUVVBSVNRVUVSIE9CUklHQcOHw5VFUyBFWElHSURBUyBQRUxPIFJFU1BFQ1RJVk8gQ09OVFJBVE8gT1UgQUNPUkRPLg0KDQpPIEluc3RpdHV0byBFdmFuZHJvIENoYWdhcyBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgZGlyZWl0b3MgZG8gZG9jdW1lbnRvIGVudHJlZ3VlIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbyBhbMOpbSBkbyBwcmV2aXN0byBuYSBhbMOtbmVhIGIpLg== |
dc.title.pt_BR.fl_str_mv |
A novel hepacivirus in wild rodents from South America |
title |
A novel hepacivirus in wild rodents from South America |
spellingShingle |
A novel hepacivirus in wild rodents from South America Souza, William Marciel de Hepacivirus / isolamento & purificação Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doenças dos Roedores / virologia |
title_short |
A novel hepacivirus in wild rodents from South America |
title_full |
A novel hepacivirus in wild rodents from South America |
title_fullStr |
A novel hepacivirus in wild rodents from South America |
title_full_unstemmed |
A novel hepacivirus in wild rodents from South America |
title_sort |
A novel hepacivirus in wild rodents from South America |
author |
Souza, William Marciel de |
author_facet |
Souza, William Marciel de Fumagalli, Marcílio Jorge Santos Jr, Gilberto Sabino Maia, Felipe Gonçalves Motta Modha, Sejal Nunes, Márcio Roberto Teixeira Murcia, Pablo Ramiro Figueiredo, Luiz Tadeu Moraes |
author_role |
author |
author2 |
Fumagalli, Marcílio Jorge Santos Jr, Gilberto Sabino Maia, Felipe Gonçalves Motta Modha, Sejal Nunes, Márcio Roberto Teixeira Murcia, Pablo Ramiro Figueiredo, Luiz Tadeu Moraes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, William Marciel de Fumagalli, Marcílio Jorge Santos Jr, Gilberto Sabino Maia, Felipe Gonçalves Motta Modha, Sejal Nunes, Márcio Roberto Teixeira Murcia, Pablo Ramiro Figueiredo, Luiz Tadeu Moraes |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Hepacivirus / isolamento & purificação Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doenças dos Roedores / virologia |
topic |
Hepacivirus / isolamento & purificação Hepatite C / patologia Flaviviridae / patogenicidade Arvicolinae / virologia Camundongos Doenças dos Roedores / virologia |
description |
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-04-09T16:10:03Z |
dc.date.available.fl_str_mv |
2019-04-09T16:10:03Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, William Marciel de et al. A novel hepacivirus in wild rodents from South America. Viruses. v. 11, n. 3, e297, p. 1-7, Mar. 2019. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3633 |
dc.identifier.issn.-.fl_str_mv |
1999-4915 |
dc.identifier.doi.-.fl_str_mv |
10.3390/v11030297 |
identifier_str_mv |
SOUZA, William Marciel de et al. A novel hepacivirus in wild rodents from South America. Viruses. v. 11, n. 3, e297, p. 1-7, Mar. 2019. 1999-4915 10.3390/v11030297 |
url |
https://patua.iec.gov.br/handle/iec/3633 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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