Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/1008 |
Resumo: | To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P ¼ 0.02, OR ¼ 0.28 and P ¼ 0.02, OR ¼ 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF. |
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Blanton, Ronald ESilva, Luciano KMorato, Vanessa GParrado, Antonio RDias, Juarez PMelo, Paulo R. SReis, Eliana A. GGoddard, Katrina A. BNunes, Márcio Roberto TeixeiraRodrigues, Sueli GuerreiroVasconcelos, Pedro Fernando da CostaCastro, Jesuina MReis, Mitermayer GBarreto, Maurício LTeixeira, M Glória2016-01-26T11:40:27Z2016-01-26T11:40:27Z2008BLANTON, Ronald E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, p. 762-765, 2008.1018-4813https://patua.iec.gov.br/handle/iec/100810.1038/ejhg.2008.4To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P ¼ 0.02, OR ¼ 0.28 and P ¼ 0.02, OR ¼ 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.Center for Global Health and Diseases. Case Western Reserve University. Cleveland, OH, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brazil.Case Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics. Cleveland, OH, USA.Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz..Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Case Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics. Cleveland, OH, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brazil.Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brazil.application/pdfengNature Publishing GroupGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDengue Grave / genéticaFatores SocioeconômicosGrupos Populacionaisinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdfapplication/pdf115239https://patua.iec.gov.br/bitstreams/6207207a-1633-419d-a45a-759ebaeb2509/download910b1e8af0e8f506e9776e1c78ae926bMD51TEXTfile_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain15731https://patua.iec.gov.br/bitstreams/777bc070-07f2-418f-b1f8-be0f776a7047/download37cfe5458f8b116f36c072f52c7f49ceMD52Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.txtGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.txtExtracted texttext/plain16420https://patua.iec.gov.br/bitstreams/7595ea14-c6ff-4115-84f8-34387d46dfb4/download7be7a9d46a95523a7790ee251c6cfc7fMD56THUMBNAILGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.jpgGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.jpgGenerated Thumbnailimage/jpeg6615https://patua.iec.gov.br/bitstreams/db94a438-c25f-4fdd-b32f-81973e68bfcf/downloada6c82ddeee9c8e826d59e58afbf14bdfMD57LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
title |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
spellingShingle |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population Blanton, Ronald E Dengue Grave / genética Fatores Socioeconômicos Grupos Populacionais |
title_short |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
title_full |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
title_fullStr |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
title_full_unstemmed |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
title_sort |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population |
author |
Blanton, Ronald E |
author_facet |
Blanton, Ronald E Silva, Luciano K Morato, Vanessa G Parrado, Antonio R Dias, Juarez P Melo, Paulo R. S Reis, Eliana A. G Goddard, Katrina A. B Nunes, Márcio Roberto Teixeira Rodrigues, Sueli Guerreiro Vasconcelos, Pedro Fernando da Costa Castro, Jesuina M Reis, Mitermayer G Barreto, Maurício L Teixeira, M Glória |
author_role |
author |
author2 |
Silva, Luciano K Morato, Vanessa G Parrado, Antonio R Dias, Juarez P Melo, Paulo R. S Reis, Eliana A. G Goddard, Katrina A. B Nunes, Márcio Roberto Teixeira Rodrigues, Sueli Guerreiro Vasconcelos, Pedro Fernando da Costa Castro, Jesuina M Reis, Mitermayer G Barreto, Maurício L Teixeira, M Glória |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Blanton, Ronald E Silva, Luciano K Morato, Vanessa G Parrado, Antonio R Dias, Juarez P Melo, Paulo R. S Reis, Eliana A. G Goddard, Katrina A. B Nunes, Márcio Roberto Teixeira Rodrigues, Sueli Guerreiro Vasconcelos, Pedro Fernando da Costa Castro, Jesuina M Reis, Mitermayer G Barreto, Maurício L Teixeira, M Glória |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Dengue Grave / genética Fatores Socioeconômicos Grupos Populacionais |
topic |
Dengue Grave / genética Fatores Socioeconômicos Grupos Populacionais |
description |
To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P ¼ 0.02, OR ¼ 0.28 and P ¼ 0.02, OR ¼ 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2016-01-26T11:40:27Z |
dc.date.available.fl_str_mv |
2016-01-26T11:40:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BLANTON, Ronald E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, p. 762-765, 2008. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/1008 |
dc.identifier.issn.-.fl_str_mv |
1018-4813 |
dc.identifier.doi.-.fl_str_mv |
10.1038/ejhg.2008.4 |
identifier_str_mv |
BLANTON, Ronald E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, p. 762-765, 2008. 1018-4813 10.1038/ejhg.2008.4 |
url |
https://patua.iec.gov.br/handle/iec/1008 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
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Nature Publishing Group |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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