Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

Detalhes bibliográficos
Autor(a) principal: Blanton, Ronald E
Data de Publicação: 2008
Outros Autores: Silva, Luciano K, Morato, Vanessa G, Parrado, Antonio R, Dias, Juarez P, Melo, Paulo R. S, Reis, Eliana A. G, Goddard, Katrina A. B, Nunes, Márcio Roberto Teixeira, Rodrigues, Sueli Guerreiro, Vasconcelos, Pedro Fernando da Costa, Castro, Jesuina M, Reis, Mitermayer G, Barreto, Maurício L, Teixeira, M Glória
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/1008
Resumo: To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P ¼ 0.02, OR ¼ 0.28 and P ¼ 0.02, OR ¼ 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
id IEC-2_4b32178d25fab432e35edd66802831de
oai_identifier_str oai:patua.iec.gov.br:iec/1008
network_acronym_str IEC-2
network_name_str Repositório Digital do Instituto Evandro Chagas (Patuá)
repository_id_str
spelling Blanton, Ronald ESilva, Luciano KMorato, Vanessa GParrado, Antonio RDias, Juarez PMelo, Paulo R. SReis, Eliana A. GGoddard, Katrina A. BNunes, Márcio Roberto TeixeiraRodrigues, Sueli GuerreiroVasconcelos, Pedro Fernando da CostaCastro, Jesuina MReis, Mitermayer GBarreto, Maurício LTeixeira, M Glória2016-01-26T11:40:27Z2016-01-26T11:40:27Z2008BLANTON, Ronald E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, p. 762-765, 2008.1018-4813https://patua.iec.gov.br/handle/iec/100810.1038/ejhg.2008.4To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P ¼ 0.02, OR ¼ 0.28 and P ¼ 0.02, OR ¼ 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.Center for Global Health and Diseases. Case Western Reserve University. Cleveland, OH, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brazil.Case Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics. Cleveland, OH, USA.Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz..Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Case Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics. Cleveland, OH, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratory of Pathology and Molecular Biology. Salvador, BA, Brazil.Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brazil.Universidade Federal da Bahia. Institute of Collective Health. Salvador, BA, Brazil.application/pdfengNature Publishing GroupGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDengue Grave / genéticaFatores SocioeconômicosGrupos Populacionaisinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdfapplication/pdf115239https://patua.iec.gov.br/bitstreams/6207207a-1633-419d-a45a-759ebaeb2509/download910b1e8af0e8f506e9776e1c78ae926bMD51TEXTfile_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain15731https://patua.iec.gov.br/bitstreams/777bc070-07f2-418f-b1f8-be0f776a7047/download37cfe5458f8b116f36c072f52c7f49ceMD52Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.txtGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.txtExtracted texttext/plain16420https://patua.iec.gov.br/bitstreams/7595ea14-c6ff-4115-84f8-34387d46dfb4/download7be7a9d46a95523a7790ee251c6cfc7fMD56THUMBNAILGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.jpgGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.pdf.jpgGenerated Thumbnailimage/jpeg6615https://patua.iec.gov.br/bitstreams/db94a438-c25f-4fdd-b32f-81973e68bfcf/downloada6c82ddeee9c8e826d59e58afbf14bdfMD57LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/8d648674-d667-4787-98db-10163f7e5051/download11832eea31b16df8613079d742d61793MD55iec/10082022-10-20 21:09:52.693oai:patua.iec.gov.br:iec/1008https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:09:52Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falsePGI+TGljZW7Dp2EgZGUgRGlzdHJpYnVpw6fDo28gTsOjbyBFeGNsdXNpdmE8L2I+DQoNClRvZG8gZGVwb3NpdGFudGUgZGUgbWF0ZXJpYWwgbm8gUGF0dcOhIGRldmUgY29uY2VkZXIgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIHVtYSBMaWNlbsOnYSBkZSBEaXN0cmlidWnDp8OjbyBOw6NvIEV4Y2x1c2l2YSBwYXJhIHRvcm5hciBlIG1hbnRlciBhY2Vzc8OtdmVpcyBvcyBzZXVzIGRvY3VtZW50b3MgZW0gZm9ybWF0byBkaWdpdGFsLiANCg0KQ29tIGEgY29uY2Vzc8OjbyBkZXNzYSBsaWNlbsOnYSBuw6NvIGV4Y2x1c2l2YSwgbyBkZXBvc2l0YW50ZSBjb250aW51YSBhIHJldGVyIHRvZG9zIG9zIGRpcmVpdG9zIGRlIGF1dG9yLg0KDQpBbyBhc3NpbmFyIGUgZW50cmVnYXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKQ0KDQphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRlIHNldSBkb2N1bWVudG8uDQoNCmIpIENvbmNlZGUgYW8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIG8gZGlyZWl0byBuw6NvIGV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyIGUvb3UgZGlzdHJpYnVpciBubyA8Yj5QYXR1w6E8L2I+LCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uDQoNCmMpIERlY2xhcmEgcXVlIGF1dG9yaXphIG8gSW5zdGl0dXRvIEV2YW5kcm8gQ2hhZ2FzIGEgYXJxdWl2YXIgbWFpcyBkZSB1bWEgY8OzcGlhIGRlc3NlIGRvY3VtZW50byBlIGNvbnZlcnTDqi1sbywgc2VtIGFsdGVyYXIgbyBzZXUgY29udGXDumRvLCBwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgZmljaGVpcm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uDQoNCmQpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCBlIHF1ZSBkZXTDqW0gbyBkaXJlaXRvIGRlIGNvbmNlZGVyIGEgdGVyY2Vpcm9zIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuDQoNCmUpIERlY2xhcmEgcXVlLCBubyBjYXNvIGRvIGRvY3VtZW50byBzdWJtZXRpZG8gY29udGVyIG1hdGVyaWFsIGRvIHF1YWwgbsOjbyBkZXTDqW0gb3MgZGlyZWl0b3MgZGUgYXV0b3IsIG9idGV2ZSBhIGF1dG9yaXphw6fDo28gaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhbyBJbnN0aXR1dG8gRXZhbmRybyBDaGFnYXMgb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIHV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBjb250ZcO6ZG8gZG8gZG9jdW1lbnRvIGVudHJlZ3VlLg0KDQpmKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSBGT1IgQkFTRUFETyBFTSBUUkFCQUxITyBGSU5BTkNJQURPIE9VIEFQT0lBRE8gUE9SIE9VVFJBIElOU1RJVFVJw4fDg08gUVVFIE7Dg08gTyBJTlNUSVRVVE8gRVZBTkRSTyBDSEFHQVMsIERFQ0xBUkEgUVVFIENVTVBSSVUgUVVBSVNRVUVSIE9CUklHQcOHw5VFUyBFWElHSURBUyBQRUxPIFJFU1BFQ1RJVk8gQ09OVFJBVE8gT1UgQUNPUkRPLg0KDQpPIEluc3RpdHV0byBFdmFuZHJvIENoYWdhcyBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgZGlyZWl0b3MgZG8gZG9jdW1lbnRvIGVudHJlZ3VlIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbyBhbMOpbSBkbyBwcmV2aXN0byBuYSBhbMOtbmVhIGIpLg==
dc.title.pt_BR.fl_str_mv Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
title Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
spellingShingle Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
Blanton, Ronald E
Dengue Grave / genética
Fatores Socioeconômicos
Grupos Populacionais
title_short Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
title_full Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
title_fullStr Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
title_full_unstemmed Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
title_sort Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
author Blanton, Ronald E
author_facet Blanton, Ronald E
Silva, Luciano K
Morato, Vanessa G
Parrado, Antonio R
Dias, Juarez P
Melo, Paulo R. S
Reis, Eliana A. G
Goddard, Katrina A. B
Nunes, Márcio Roberto Teixeira
Rodrigues, Sueli Guerreiro
Vasconcelos, Pedro Fernando da Costa
Castro, Jesuina M
Reis, Mitermayer G
Barreto, Maurício L
Teixeira, M Glória
author_role author
author2 Silva, Luciano K
Morato, Vanessa G
Parrado, Antonio R
Dias, Juarez P
Melo, Paulo R. S
Reis, Eliana A. G
Goddard, Katrina A. B
Nunes, Márcio Roberto Teixeira
Rodrigues, Sueli Guerreiro
Vasconcelos, Pedro Fernando da Costa
Castro, Jesuina M
Reis, Mitermayer G
Barreto, Maurício L
Teixeira, M Glória
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Blanton, Ronald E
Silva, Luciano K
Morato, Vanessa G
Parrado, Antonio R
Dias, Juarez P
Melo, Paulo R. S
Reis, Eliana A. G
Goddard, Katrina A. B
Nunes, Márcio Roberto Teixeira
Rodrigues, Sueli Guerreiro
Vasconcelos, Pedro Fernando da Costa
Castro, Jesuina M
Reis, Mitermayer G
Barreto, Maurício L
Teixeira, M Glória
dc.subject.decsPrimary.pt_BR.fl_str_mv Dengue Grave / genética
Fatores Socioeconômicos
Grupos Populacionais
topic Dengue Grave / genética
Fatores Socioeconômicos
Grupos Populacionais
description To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P ¼ 0.02, OR ¼ 0.28 and P ¼ 0.02, OR ¼ 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2016-01-26T11:40:27Z
dc.date.available.fl_str_mv 2016-01-26T11:40:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BLANTON, Ronald E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, p. 762-765, 2008.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/1008
dc.identifier.issn.-.fl_str_mv 1018-4813
dc.identifier.doi.-.fl_str_mv 10.1038/ejhg.2008.4
identifier_str_mv BLANTON, Ronald E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, p. 762-765, 2008.
1018-4813
10.1038/ejhg.2008.4
url https://patua.iec.gov.br/handle/iec/1008
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
bitstream.url.fl_str_mv https://patua.iec.gov.br/bitstreams/6207207a-1633-419d-a45a-759ebaeb2509/download
https://patua.iec.gov.br/bitstreams/777bc070-07f2-418f-b1f8-be0f776a7047/download
https://patua.iec.gov.br/bitstreams/7595ea14-c6ff-4115-84f8-34387d46dfb4/download
https://patua.iec.gov.br/bitstreams/db94a438-c25f-4fdd-b32f-81973e68bfcf/download
https://patua.iec.gov.br/bitstreams/8d648674-d667-4787-98db-10163f7e5051/download
bitstream.checksum.fl_str_mv 910b1e8af0e8f506e9776e1c78ae926b
37cfe5458f8b116f36c072f52c7f49ce
7be7a9d46a95523a7790ee251c6cfc7f
a6c82ddeee9c8e826d59e58afbf14bdf
11832eea31b16df8613079d742d61793
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
_version_ 1809190034716229632