Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil

• Autor(a) principal: Nogueira, Mauricio Lacerda
• Data de Publicação: 2018
• Outros Autores: Nery Junior, Nivison Ruy Rocha, Estofolete, Cássia Fernanda, Terzian, Ana Carolina Bernardes, Guimarães, Georgia de Freitas, Zini, Nathalia, Silva, Rafaela Alves da, Silva, Gislaine Celestino Dutra, Franco, Ligia Cosentino Junqueira, Rahal, Paula, Bittar, Cintia, Carneiro, Bruno, Vasconcelos, Pedro Fernando da Costa, Henriques, Daniele Freitas, Barbosa, Deusenia Machado Ulisses, Rombola, Patricia Lopes, Grande, Luciana de, Reis, Andréia Francesli Negri, Palomares, Sacha Ariane, Catelan, Marcia Wakai, Cruz, Lilian Elisa Arão Antonio, Necchi, Silvia Helena, Mendonça, Rita de Cassia Vilella, Santos, Izalco Nuremberg Penha dos, Caron, Suzimeire Brigatti Alavarse, Costa, Federico, Bozza, Fernando A, Souza, Antonio Soares de, Mattos, Cinara Cássia Brandão de, Matos, Luiz Carlos de, Vasilakis, Nikos, Oliani, Antonio Helio, Oliani, Denise Cristina Mós Vaz, Ko, Alberto Icksang
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3063
• topic: Zika Virus / patogenicidade; Infecção por Zika Virus / virologia; Dengue; Gravidez; Gestantes; Saúde Pública; Microcefalia; Reação em Cadeia da Polimerase Via Transcriptase Reversa / métodos

Objectives: We aimed to report the first 54 cases of pregnant women infected by Zika virus (ZIKV) and their virologic and clinical outcomes, as well as their newborns' outcomes, in 2016, after the emergence of ZIKV in dengue-endemic areas of São Paulo, Brazil. Methods: This descriptive study was performed from February to October 2016 on 54 quantitative realtime PCR ZIKV-positive pregnant women identified by the public health authority of Sao José do Rio Preto, São Paulo, Brazil. The women were followed and had clinical and epidemiologic data collected before and after birth. Adverse outcomes in newborns were analysed and reported. Urine or blood samples from newborns were collected to identify ZIKV infection by reverse transcription PCR (RT-PCR). Results: A total of 216 acute Zika-suspected pregnant women were identified, and 54 had the diagnosis confirmed by RT-PCR. None of the 54 women miscarried. Among the 54 newborns, 15 exhibited adverse outcomes at birth. The highest number of ZIKV infections occurred during the second and third trimesters. No cases of microcephaly were reported, though a broad clinical spectrum of outcomes, including lenticulostriate vasculopathy, subependymal cysts, and auditory and ophthalmologic disorders, were identified. ZIKV RNA was detected in 18 of 51 newborns tested and in eight of 15 newborns with adverse outcomes. Conclusions: Although other studies have associated many newborn outcomes to ZIKV infection during pregnancy, these same adverse outcomes were rare or nonexistent in this study. The clinical presentation the newborns we studied was mild compared to other reports, suggesting that there is significant heterogeneity in congenital Zika infection.