Guillain–Barré Syndrome after Zika Virus Infection in Brazil: case report

• Autor(a) principal: Rosário, Mateus Santana do
• Data de Publicação: 2016
• Outros Autores: Jesus, Pedro Antonio Pereira de, Vasilakis, Nikos, Farias, Daniel Santana, Novaes, Marco Antônio Caires, Rodrigues, Sueli Guerreiro, Martins, Lívia Caricio, Vasconcelos, Pedro Fernando da Costa, Ko, Albert Icksang, Alcantara, Luiz Carlos Júnior, Siqueira, Isadora Cristina de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/2468
• topic: Infecção pelo Zika virus / diagnóstico; Infecção pelo Zika virus / complicações; Síndrome de Guillain-Barré / complicações; Doenças do Sistema Nervoso / complicações; Testes de Inibição da Hemaglutinação / métodos; Ensaio de Imunoadsorção Enzimática / métodos; Reação em Cadeia da Polimerase Via Transcriptase Reversa / métodos; Brasil / epidemiologia

Zika virus (ZIKV) is an emerging flavivirus, which has caused a widespread outbreak in the Americas. Shortly after its introduction in 2015, a cluster of cases with Guillain-Barré syndrome was detected in Brazil. Herein, we describe two cases from the city of Salvador, who developed ascending paresis after an acute exanthematous illness. The patients were admitted to the intensive care unit with tetraparesis and cranial nerve palsy, which resolved after intravenous administration of human immunoglobulin. Serological evaluation detected IgM-specific ZIKV antibodies. In regions of Zika virus transmission, health-care workers must be aware of the potential severe neurological complications associated with ZIKV infection and be prepared to provide prompt diagnosis, treatment, and supportive care.