Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
| Texto Completo: | https://patua.iec.gov.br/handle/iec/1910 |
Resumo: | Trabalho apresentado no Encontro Nacional de Virologia, 14., 2003, Florianópolis |
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Macêdo, OlindaLima, Telma V. RibeiroLinhares, Adriana de OMoura, Antônio deGomes, Maria de Lourdes ContenteLinhares, Alexandre da Costa2016-01-26T13:41:29Z2016-01-26T13:41:29Z2003MACÊDO, Olinda et al. Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 46, n. 1, p. 13-17, jan.-fev. 2004.https://patua.iec.gov.br/handle/iec/1910Trabalho apresentado no Encontro Nacional de Virologia, 14., 2003, FlorianópolisSerum- and/or- cerebrospinal fluid (CSF) samples obtained from 190 patients suffering from chronic, progressive neurological disease were screened for the presence of human T-cell lymphotropic viruses type I (HTLV-I) and type II (HTLV-II) antibodies over a six-year period (1996 to 2001) in Belém, Pará, Brazil. Patients were of both sexes (male subjects, 52%) with ages ranging from 2 to 79 years (mean, 35.9). Overall, 15 (7.9%) subjects - of whom 12 (80%) were female adults - reacted HTLV-I/II-seropositive when screened by enzyme-linked immunosorbent assay (ELISA). Serum samples from 14 of these patients were also analyzed using a recombinant Western blot (WB) assay that yielded HTLV-I-, HTLV-II-, and HTLV-I/II- reactivities for 10 (71.4%), 3 (21.4%) and 1 (7.2%) of them, respectively. The yearly rates of HTLV-I/II antibodies ranged from 2.6% (2001) to 21.7% (2000), with progressively increasing seropositivities from 1998 to 2000. Altogether, walking difficulty (n = 5 subjects), spasticity (n = 4) and leg weakness (n = 3) accounted for 80% of symptoms recorded among the 15 patients whose sera had antibodies to HTLV-I/II as detected by ELISA. These findings provide evidence that both HTLV-I and HTLV-II play a role in the development of chronic myelopathy in Belém, Pará, Northern Brazil.Amostras de soro e/ou líquido céfalo-raquidiano (LCR) foram obtidas de 190 pacientes com quadro de doença neurológica crônica e progressiva, com vistas à detecção de anticorpos para os vírus linfotrópicos humanos de células T dos tipos I (HTLV-I) e II (HTLV-II), durante um período de seis anos (1996 a 2001) em Belém, Pará, Brasil. O grupo compreendia ambos os sexos (homens, 52%), com idades variando de 2 a 79 anos (média, 35,9 anos). Tomando-se os resultados como um todo, 15 (7,9%) indivíduos, incluindo 12 (80%) mulheres adultas, apresentaram anticorpos para HTLV-I/II a partir da triagem pelo procedimento imunoenzimático (ELISA). Soros de 14 desses pacientes também foram testados utilizando-se procedimento de Western blot (WB), alcançando-se freqüências de anticorpos para HTLV-I, HTLV-II e dupla reação (HTLV-I e HTLV-II) em 10 (71,4%), 3 (21,4%) e 1 (7,2%) indivíduos, respectivamente. As freqüências anuais de positividade para HTLV-I/II variaram de 2,6% (2001) a 21,7% (2000), em escala crescente no período de 1998 a 2000. Em conjunto, dificuldade na deambulação (n = 5 pacientes), espasticidade (n = 4) e hipotonia crural compreenderam 80% das manifestações clínicas registradas entre os 15 pacientes cujas amostras de soro continham anticorpos para HTLV-I/II, com base em ELISA. Tais resultados oferecem indicadores quanto a uma possível associação do HTLV-I e do HTLV-II à gênese das mielopatias crônicas em Belém, norte do Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.Universidade Federal do Pará, Belém, PA, Brasil.Universidade Federal do Pará, Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.application/pdfengUniversidade de São PauloHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, BrazilInfecção pelos vírus linfotrópicos humanos de células T tipos I e II entre pacientes com doença neurológica em Belém, Pará, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAnticorpos Anti-HTLV-I / análiseAnticorpos Anti-HTLV-II / análiseDoenças da Medula EspinhalParaparesia Espástica TropicalInfecções por HTLV-I / diagnósticoInfecções por HTLV-I / fisiopatologiaInfecções por HTLV-II / complicaçõesInfecções por HTLV-II / diagnósticoInfecções por HTLV-II / fisiopatologiaInfecções por HTLV-I / complicaçõesDoenças do Sistema Nervoso / virologiaLinfócitos T / virologiaVírus 1 Linfotrópico T HumanoVírus 2 Linfotrópico T Humanoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil.pdfHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil.pdfapplication/pdf299219https://patua.iec.gov.br/bitstreams/479c143b-227c-417a-9836-f4ebf3f1457f/download51785f0a55a753591745bcaf11dffbfaMD54Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil [Pôster].pdfHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil [Pôster].pdfapplication/pdf2649959https://patua.iec.gov.br/bitstreams/109b39b6-dbf5-487b-9c7c-049e7297b35f/downloadd05bf1fc34d11253c68e205f254f0b43MD51TEXTHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil.pdf.txtHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil.pdf.txtExtracted texttext/plain30488https://patua.iec.gov.br/bitstreams/05bc0429-0a40-4648-b8f6-ed1c65cf07fb/downloadf1a22265417a65c9def61834e2681c78MD58Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil [Pôster].pdf.txtHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil [Pôster].pdf.txtExtracted texttext/plain7406https://patua.iec.gov.br/bitstreams/d068a841-248d-4057-8ccf-9ea13d941e04/downloadac6877558c42a3823fa5d6f1264a8828MD510THUMBNAILHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil.pdf.jpgHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5541https://patua.iec.gov.br/bitstreams/a8fb12b8-29af-4cc7-bf53-575c7ce60060/download531af7a2c5f77994a32241f2b119d024MD59Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil [Pôster].pdf.jpgHuman t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil [Pôster].pdf.jpgGenerated Thumbnailimage/jpeg7848https://patua.iec.gov.br/bitstreams/e6f233db-7860-4088-bc77-fd9b9018512b/download9f9cc319f4269f0b87559cedd4c6fd23MD511LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
Infecção pelos vírus linfotrópicos humanos de células T tipos I e II entre pacientes com doença neurológica em Belém, Pará, Brasil |
| title |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| spellingShingle |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil Macêdo, Olinda Anticorpos Anti-HTLV-I / análise Anticorpos Anti-HTLV-II / análise Doenças da Medula Espinhal Paraparesia Espástica Tropical Infecções por HTLV-I / diagnóstico Infecções por HTLV-I / fisiopatologia Infecções por HTLV-II / complicações Infecções por HTLV-II / diagnóstico Infecções por HTLV-II / fisiopatologia Infecções por HTLV-I / complicações Doenças do Sistema Nervoso / virologia Linfócitos T / virologia Vírus 1 Linfotrópico T Humano Vírus 2 Linfotrópico T Humano |
| title_short |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| title_full |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| title_fullStr |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| title_full_unstemmed |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| title_sort |
Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil |
| author |
Macêdo, Olinda |
| author_facet |
Macêdo, Olinda Lima, Telma V. Ribeiro Linhares, Adriana de O Moura, Antônio de Gomes, Maria de Lourdes Contente Linhares, Alexandre da Costa |
| author_role |
author |
| author2 |
Lima, Telma V. Ribeiro Linhares, Adriana de O Moura, Antônio de Gomes, Maria de Lourdes Contente Linhares, Alexandre da Costa |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Macêdo, Olinda Lima, Telma V. Ribeiro Linhares, Adriana de O Moura, Antônio de Gomes, Maria de Lourdes Contente Linhares, Alexandre da Costa |
| dc.subject.decsPrimary.pt_BR.fl_str_mv |
Anticorpos Anti-HTLV-I / análise Anticorpos Anti-HTLV-II / análise Doenças da Medula Espinhal Paraparesia Espástica Tropical Infecções por HTLV-I / diagnóstico Infecções por HTLV-I / fisiopatologia Infecções por HTLV-II / complicações Infecções por HTLV-II / diagnóstico Infecções por HTLV-II / fisiopatologia Infecções por HTLV-I / complicações Doenças do Sistema Nervoso / virologia Linfócitos T / virologia Vírus 1 Linfotrópico T Humano Vírus 2 Linfotrópico T Humano |
| topic |
Anticorpos Anti-HTLV-I / análise Anticorpos Anti-HTLV-II / análise Doenças da Medula Espinhal Paraparesia Espástica Tropical Infecções por HTLV-I / diagnóstico Infecções por HTLV-I / fisiopatologia Infecções por HTLV-II / complicações Infecções por HTLV-II / diagnóstico Infecções por HTLV-II / fisiopatologia Infecções por HTLV-I / complicações Doenças do Sistema Nervoso / virologia Linfócitos T / virologia Vírus 1 Linfotrópico T Humano Vírus 2 Linfotrópico T Humano |
| description |
Trabalho apresentado no Encontro Nacional de Virologia, 14., 2003, Florianópolis |
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2003 |
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2003 |
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2016-01-26T13:41:29Z |
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2016-01-26T13:41:29Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MACÊDO, Olinda et al. Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 46, n. 1, p. 13-17, jan.-fev. 2004. |
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https://patua.iec.gov.br/handle/iec/1910 |
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MACÊDO, Olinda et al. Human t-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 46, n. 1, p. 13-17, jan.-fev. 2004. |
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eng |
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Universidade de São Paulo |
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Universidade de São Paulo |
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