The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment

Detalhes bibliográficos
Autor(a) principal: Sortica, Vinicius Albuquerque
Data de Publicação: 2016
Outros Autores: Lindenau, Juliana D, Cunha, Maristela G, Ohnishi, Maria D. O, Ventura, Ana Maria Revorêdo da Silva, Santos, Andrea Kely Campos Ribeiro dos, Santos, Sidney E. B, Guimarães, Luciano S. P, Hutz, Mara H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/2502
Resumo: Background: Chloroquine/primaquine is the current therapy to eliminate Plasmodium vivax infection in the Amazon region. Aims: This study investigates CYP1A2, CYP2C8, CYP2C9, CYP3A4 and CYP3A5 genetic polymorphisms influence on cloroquine/primaquine treatment. Patients & methods: Generalized estimating equations analyses were performed to determine the genetic influence in parasitemia and/or gametocytemia clearance over treatment time in 164 patients. Results: An effect of CYP2C8 low-activity alleles on treatment was observed (p = 0.01). From baseline to first day of treatment, wild-type individuals achieved greater reduction of gametocytes than low-activity allele carriers. CYP2C9 and CYP3A5 genes showed a trend for gametocytemia and parasitemia clearance rates. Conclusion: Future studies should be performed to access the extent of CYP2C8, CYP2C9 and CYP3A5 gene polymorphisms influence on cloroquine/primaquine treatment.
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spelling Sortica, Vinicius AlbuquerqueLindenau, Juliana DCunha, Maristela GOhnishi, Maria D. OVentura, Ana Maria Revorêdo da SilvaSantos, Andrea Kely Campos Ribeiro dosSantos, Sidney E. BGuimarães, Luciano S. PHutz, Mara H2017-02-10T17:16:21Z2017-02-10T17:16:21Z2016SORTICA, Vinicius A. et al. The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment. Pharmacogenomics. v. 17, n. 17, p. 1903-1911, Nov. 2016.1744-8042https://patua.iec.gov.br/handle/iec/250210.2217/pgs-2016-0131Background: Chloroquine/primaquine is the current therapy to eliminate Plasmodium vivax infection in the Amazon region. Aims: This study investigates CYP1A2, CYP2C8, CYP2C9, CYP3A4 and CYP3A5 genetic polymorphisms influence on cloroquine/primaquine treatment. Patients & methods: Generalized estimating equations analyses were performed to determine the genetic influence in parasitemia and/or gametocytemia clearance over treatment time in 164 patients. Results: An effect of CYP2C8 low-activity alleles on treatment was observed (p = 0.01). From baseline to first day of treatment, wild-type individuals achieved greater reduction of gametocytes than low-activity allele carriers. CYP2C9 and CYP3A5 genes showed a trend for gametocytemia and parasitemia clearance rates. Conclusion: Future studies should be performed to access the extent of CYP2C8, CYP2C9 and CYP3A5 gene polymorphisms influence on cloroquine/primaquine treatment.The authors thank the financial support provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil)Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.Universidade Federal do Pará. Laboratório de Microbiologia e Imunologia. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brazil.Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brazil.Hospital de Clínicas de Porto Alegre.Grupo de Pesquisa e Pós Graduação. Unidade de Bioestatística. Porto Alegre, RS, Brazil.Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.engFuture MedicineThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalária / quimioterapiaMalária / terapiaCYP2C8CYP2C9CYP3A5FarmacogenéticaCloroquina / uso terapêuticoPrimaquina / uso terapêuticoAntimaláricos / uso terapêuticoPlasmodium vivax / efeitos de drogasPolimorfismo Genético / genéticaParasitemiaResultado do TratamentoEcossistema AmazônicoBrasil (BR)info:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECTHUMBNAILThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.pdf.jpgThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.pdf.jpgGenerated Thumbnailimage/jpeg5675https://patua.iec.gov.br/bitstreams/3aca57fc-bdf1-436a-b479-cefe6fc5c5e0/download61e3f2f3782d19f1b6ba1d0ca2ae7783MD58ORIGINALThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.pdfThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.pdfapplication/pdf1114737https://patua.iec.gov.br/bitstreams/179b4d97-1508-4e5f-8e2a-72a6da055ad4/downloadb8435c4a437f38da730e7d15fae5eabeMD56LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/4ab473e9-8520-40d3-958d-1942d821773e/download52f1732ea66fbd1123abe39f5373b797MD52TEXTThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.pdf.txtThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment.pdf.txtExtracted texttext/plain34005https://patua.iec.gov.br/bitstreams/322d6e0d-51a2-4cda-9c62-3d91816bbc42/download4762b5364b68b7a1cf8c6ed65b8954ddMD57iec/25022022-10-20 22:24:04.883oai:patua.iec.gov.br:iec/2502https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:24:04Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
title The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
spellingShingle The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
Sortica, Vinicius Albuquerque
Malária / quimioterapia
Malária / terapia
CYP2C8
CYP2C9
CYP3A5
Farmacogenética
Cloroquina / uso terapêutico
Primaquina / uso terapêutico
Antimaláricos / uso terapêutico
Plasmodium vivax / efeitos de drogas
Polimorfismo Genético / genética
Parasitemia
Resultado do Tratamento
Ecossistema Amazônico
Brasil (BR)
title_short The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
title_full The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
title_fullStr The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
title_full_unstemmed The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
title_sort The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment
author Sortica, Vinicius Albuquerque
author_facet Sortica, Vinicius Albuquerque
Lindenau, Juliana D
Cunha, Maristela G
Ohnishi, Maria D. O
Ventura, Ana Maria Revorêdo da Silva
Santos, Andrea Kely Campos Ribeiro dos
Santos, Sidney E. B
Guimarães, Luciano S. P
Hutz, Mara H
author_role author
author2 Lindenau, Juliana D
Cunha, Maristela G
Ohnishi, Maria D. O
Ventura, Ana Maria Revorêdo da Silva
Santos, Andrea Kely Campos Ribeiro dos
Santos, Sidney E. B
Guimarães, Luciano S. P
Hutz, Mara H
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sortica, Vinicius Albuquerque
Lindenau, Juliana D
Cunha, Maristela G
Ohnishi, Maria D. O
Ventura, Ana Maria Revorêdo da Silva
Santos, Andrea Kely Campos Ribeiro dos
Santos, Sidney E. B
Guimarães, Luciano S. P
Hutz, Mara H
dc.subject.decsPrimary.pt_BR.fl_str_mv Malária / quimioterapia
Malária / terapia
CYP2C8
CYP2C9
CYP3A5
Farmacogenética
Cloroquina / uso terapêutico
Primaquina / uso terapêutico
Antimaláricos / uso terapêutico
Plasmodium vivax / efeitos de drogas
Polimorfismo Genético / genética
Parasitemia
Resultado do Tratamento
Ecossistema Amazônico
Brasil (BR)
topic Malária / quimioterapia
Malária / terapia
CYP2C8
CYP2C9
CYP3A5
Farmacogenética
Cloroquina / uso terapêutico
Primaquina / uso terapêutico
Antimaláricos / uso terapêutico
Plasmodium vivax / efeitos de drogas
Polimorfismo Genético / genética
Parasitemia
Resultado do Tratamento
Ecossistema Amazônico
Brasil (BR)
description Background: Chloroquine/primaquine is the current therapy to eliminate Plasmodium vivax infection in the Amazon region. Aims: This study investigates CYP1A2, CYP2C8, CYP2C9, CYP3A4 and CYP3A5 genetic polymorphisms influence on cloroquine/primaquine treatment. Patients & methods: Generalized estimating equations analyses were performed to determine the genetic influence in parasitemia and/or gametocytemia clearance over treatment time in 164 patients. Results: An effect of CYP2C8 low-activity alleles on treatment was observed (p = 0.01). From baseline to first day of treatment, wild-type individuals achieved greater reduction of gametocytes than low-activity allele carriers. CYP2C9 and CYP3A5 genes showed a trend for gametocytemia and parasitemia clearance rates. Conclusion: Future studies should be performed to access the extent of CYP2C8, CYP2C9 and CYP3A5 gene polymorphisms influence on cloroquine/primaquine treatment.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-10T17:16:21Z
dc.date.available.fl_str_mv 2017-02-10T17:16:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SORTICA, Vinicius A. et al. The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment. Pharmacogenomics. v. 17, n. 17, p. 1903-1911, Nov. 2016.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/2502
dc.identifier.issn.-.fl_str_mv 1744-8042
dc.identifier.doi.-.fl_str_mv 10.2217/pgs-2016-0131
identifier_str_mv SORTICA, Vinicius A. et al. The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment. Pharmacogenomics. v. 17, n. 17, p. 1903-1911, Nov. 2016.
1744-8042
10.2217/pgs-2016-0131
url https://patua.iec.gov.br/handle/iec/2502
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
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