Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4346 |
Resumo: | The origin and geographical spread of Plasmodium falciparum is here determined by analysis of mitochondrial DNA sequence polymorphism and divergence from its most closely related species P. reichenowi (a rare parasite of chimpanzees). The complete 6 kb mitochondrial genome was sequenced from the single known isolate of P. reichenowi and from four different cultured isolates of P. falciparum, and aligned with the two previously derived P. falciparum sequences. The extremely low synonymous nucleotide polymorphism in P. falciparum (pi=0.0004) contrasts with the divergence at such sites between the two species (kappa=0.1201), and supports a hypothesis that P. falciparum has recently emerged from a single ancestral population. To survey the geographical distribution of mitochondrial haplotypes in P. falciparum, 104 isolates from several endemic areas were typed for each of the identified single nucleotide polymorphisms. The haplotypes show a radiation out of Africa, with unique types in Southeast Asia and South America being related to African types by single nucleotide changes. This indicates that P. falciparum originated in Africa and colonised Southeast Asia and South America separately. |
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Conway, David JFanello, CaterinaLloyd, Jennifer MAl-Joubori, Ban M. A. SBalach, Aftab HSomanath, Sushela DRoper, CallyOduola, Ayoade M. JMulder, BertPóvoa, Marinete MarinsSingh, BalbirThomas, Alan W2021-07-13T14:07:35Z2021-07-13T14:07:35Z2000CONWAY, David J. et al. Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA. Molecular and Biochemical Parasitology, v. 111, n. 1, p. 163-171, Nov. 2000. DOI: https://doi.org/10.1016/s0166-6851(00)00313-3.0166-6851https://patua.iec.gov.br/handle/iec/434610.1016/s0166-6851(00)00313-3The origin and geographical spread of Plasmodium falciparum is here determined by analysis of mitochondrial DNA sequence polymorphism and divergence from its most closely related species P. reichenowi (a rare parasite of chimpanzees). The complete 6 kb mitochondrial genome was sequenced from the single known isolate of P. reichenowi and from four different cultured isolates of P. falciparum, and aligned with the two previously derived P. falciparum sequences. The extremely low synonymous nucleotide polymorphism in P. falciparum (pi=0.0004) contrasts with the divergence at such sites between the two species (kappa=0.1201), and supports a hypothesis that P. falciparum has recently emerged from a single ancestral population. To survey the geographical distribution of mitochondrial haplotypes in P. falciparum, 104 isolates from several endemic areas were typed for each of the identified single nucleotide polymorphisms. The haplotypes show a radiation out of Africa, with unique types in Southeast Asia and South America being related to African types by single nucleotide changes. This indicates that P. falciparum originated in Africa and colonised Southeast Asia and South America separately.Financial support was provided by The Wellcome Trust (grant ref. 055487), the European Commission, and the University of London Central Research FundLondon School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases. Keppel St, London, UK.University of Ibadan. College of Medicine. Ibadan, Nigeria.Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale. Malaria Department. Yaounde, Cameroon.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universiti Malaysia Sarawak. Kota Samarahan. Sarawak, Malaysia.Biomedical Primate Research Centre. Rijswijk, The Netherlands.engElsevierOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNAinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePlasmodium falciparum / patogenicidadeGenoma Mitocondrial / genéticaPlasmodium reichenowiVariação Genética / genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNA.pdfOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNA.pdfapplication/pdf190139https://patua.iec.gov.br/bitstreams/b052cfde-669c-4ff1-9680-e02597596726/download80b11e92761e3961a7f6065671a87a9fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/db9fa9ca-f141-44c6-b734-b2448e8def5e/download11832eea31b16df8613079d742d61793MD52TEXTOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNA.pdf.txtOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNA.pdf.txtExtracted texttext/plain32738https://patua.iec.gov.br/bitstreams/84f03362-5b00-4f6b-a856-8abd4a1996a1/download844226e5e16ee2f6ca7dc4f6454d10f1MD55THUMBNAILOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNA.pdf.jpgOrigin of Plasmodium falciparum malaria is traced by mitochondrial DNA.pdf.jpgGenerated Thumbnailimage/jpeg6254https://patua.iec.gov.br/bitstreams/9b8e92c0-9d81-45ab-a382-1a2f93a9ac02/downloadae82881438b95463b3548c82ddf3a0abMD56iec/43462022-10-20 22:21:51.961oai:patua.iec.gov.br:iec/4346https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:21:51Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
title |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
spellingShingle |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA Conway, David J Plasmodium falciparum / patogenicidade Genoma Mitocondrial / genética Plasmodium reichenowi Variação Genética / genética |
title_short |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
title_full |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
title_fullStr |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
title_full_unstemmed |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
title_sort |
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA |
author |
Conway, David J |
author_facet |
Conway, David J Fanello, Caterina Lloyd, Jennifer M Al-Joubori, Ban M. A. S Balach, Aftab H Somanath, Sushela D Roper, Cally Oduola, Ayoade M. J Mulder, Bert Póvoa, Marinete Marins Singh, Balbir Thomas, Alan W |
author_role |
author |
author2 |
Fanello, Caterina Lloyd, Jennifer M Al-Joubori, Ban M. A. S Balach, Aftab H Somanath, Sushela D Roper, Cally Oduola, Ayoade M. J Mulder, Bert Póvoa, Marinete Marins Singh, Balbir Thomas, Alan W |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Conway, David J Fanello, Caterina Lloyd, Jennifer M Al-Joubori, Ban M. A. S Balach, Aftab H Somanath, Sushela D Roper, Cally Oduola, Ayoade M. J Mulder, Bert Póvoa, Marinete Marins Singh, Balbir Thomas, Alan W |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Plasmodium falciparum / patogenicidade Genoma Mitocondrial / genética Plasmodium reichenowi Variação Genética / genética |
topic |
Plasmodium falciparum / patogenicidade Genoma Mitocondrial / genética Plasmodium reichenowi Variação Genética / genética |
description |
The origin and geographical spread of Plasmodium falciparum is here determined by analysis of mitochondrial DNA sequence polymorphism and divergence from its most closely related species P. reichenowi (a rare parasite of chimpanzees). The complete 6 kb mitochondrial genome was sequenced from the single known isolate of P. reichenowi and from four different cultured isolates of P. falciparum, and aligned with the two previously derived P. falciparum sequences. The extremely low synonymous nucleotide polymorphism in P. falciparum (pi=0.0004) contrasts with the divergence at such sites between the two species (kappa=0.1201), and supports a hypothesis that P. falciparum has recently emerged from a single ancestral population. To survey the geographical distribution of mitochondrial haplotypes in P. falciparum, 104 isolates from several endemic areas were typed for each of the identified single nucleotide polymorphisms. The haplotypes show a radiation out of Africa, with unique types in Southeast Asia and South America being related to African types by single nucleotide changes. This indicates that P. falciparum originated in Africa and colonised Southeast Asia and South America separately. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2021-07-13T14:07:35Z |
dc.date.available.fl_str_mv |
2021-07-13T14:07:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CONWAY, David J. et al. Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA. Molecular and Biochemical Parasitology, v. 111, n. 1, p. 163-171, Nov. 2000. DOI: https://doi.org/10.1016/s0166-6851(00)00313-3. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4346 |
dc.identifier.issn.-.fl_str_mv |
0166-6851 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/s0166-6851(00)00313-3 |
identifier_str_mv |
CONWAY, David J. et al. Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA. Molecular and Biochemical Parasitology, v. 111, n. 1, p. 163-171, Nov. 2000. DOI: https://doi.org/10.1016/s0166-6851(00)00313-3. 0166-6851 10.1016/s0166-6851(00)00313-3 |
url |
https://patua.iec.gov.br/handle/iec/4346 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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