Comparative analysis of human hepatic lesions in Dengue, Yellow Fever, and Chikungunya: revisiting histopathological changes in the light of modern knowledge of cell pathology

• Autor(a) principal: Ribeiro, Yasmin Pacheco
• Data de Publicação: 2023
• Outros Autores: Falcão, Luiz Fabio Magno, Smith, Vanessa Cavaleiro, Sousa, Jorge Rodrigues de, Pagliari, Carla, Franco, Edna Cristina Santos, Cruz, Ana Cecília Ribeiro, Chiang, Janniffer Oliveira, Martins, Livia Carício, Nunes, Juliana Abreu Lima, Vilacoert, Fellipe Souza da Silva, Santos, Lais Carneiro dos, Furlaneto, Matheus Perini, Fuzii, Hellen Thais, Bertonsin Filho, Marcos Virgilio, Costa, Luccas Delgado da, Duarte, Maria Irma Seixas, Furlaneto, Ismari Perini, Martins Filho, Arnaldo Jorge, Aarão, Tinara Leila de Souza, Vasconcelos, Pedro Fernando da Costa, Quaresma, Juarez Antônio Simões
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/6834
• topic: Arbovírus / patogenicidade; Infecções por Arbovirus; Fígado / lesões; Vírus da Febre Amarela; Vírus Chikungunya; Vírus da Dengue; Necrose

Arboviruses, such as yellow fever virus (YFV), dengue virus (DENV), and chikungunya virus (CHIKV), present wide global dissemination and a pathogenic profile developed in infected individuals, from non-specific clinical conditions to severe forms, characterised by the promotion of significant lesions in different organs of the harbourer, culminating in multiple organ dysfunction. An analytical cross-sectional study was carried out via the histopathological analysis of 70 samples of liver patients, collected between 2000 and 2017, with confirmed laboratory diagnoses, who died due to infection and complications due to yellow fever (YF), dengue fever (DF), and chikungunya fever (CF), to characterise, quantify, and compare the patterns of histopathological alterations in the liver between the samples. Of the histopathological findings in the human liver samples, there was a significant difference between the control and infection groups, with a predominance of alterations in the midzonal area of the three cases analysed. Hepatic involvement in cases of YF showed a greater intensity of histopathological changes. Among the alterations evaluated, cell swelling, microvesicular steatosis, and apoptosis were classified according to the degree of tissue damage from severe to very severe. Pathological abnormalities associated with YFV, DENV, and CHIKV infections showed a predominance of changes in the midzonal area. We also noted that, among the arboviruses studied, liver involvement in cases of YFV infection was more intense.