Association of polymorphisms of IL-6 pathway genes (IL6, IL6R and IL6ST) with COVID-19 severity in an amazonian population

• Autor(a) principal: Rodrigues, Fabíola Brasil Barbosa
• Data de Publicação: 2023
• Outros Autores: Silva, Rosilene da, Santos, Erika Ferreira dos, Brito, Mioni Thieli Figueiredo Magalhães de, Silva, Andréa Luciana Soares da, Leite, Mauro de Meira, Costa, Flávia Póvoa da, Viana, Maria de Nazaré do Socorro de Almeida, Sarges, Kevin Matheus Lima de, Cantanhede, Marcos Henrique Damasceno, Veríssimo, Adriana de Oliviera Lameira, Carvalho, Mayara da Silva, Henriques, Daniele Freitas, Silva, Carla Pinheiro da, Costa, Igor Brasil, Nunes, Juliana Abreu Lima, Costa, Iran Barros, Viana, Giselle Maria Rachid, Queiroz, Maria Alice Freitas, Lima, Sandra Souza, Lopes, Jeferson da Costa, Torres, Maria Karoliny da Silva, Vallinoto, Izaura Maria Vieira Cayres, Bichara, Carlos David Araújo, Vallinoto, Antonio Carlos Rosário, Santos, Eduardo José Melo dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/6838
• topic: Polimorfismo Genético / genética; Interleucina-6 / análise; Receptores de Interleucina-6; SARS-CoV-2 / patogenicidade; COVID-19

Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6. IL6R and IL6ST genes, respectively, in 227 COVID-19 patients (132 hospitalized and 95 non-hospitalized). Genotype frequencies were compared between these groups. As a control group, published data on gene and genotype frequencies were gathered from published studies before the pandemic started. Our major results point to an association of the IL6 C allele with COVID-19 severity. Moreover, IL-6 plasmatic levels were higher among IL6 CC genotype carriers. Additionally, the frequency of symptoms was higher at IL6 CC and IL6R CC genotypes. In conclusion, the data suggest an important role of IL6 C allele and IL6R CC genotype on COVID-19 severity, in agreement with indirect evidence from the literature about the association of these genotypes with mortality rates, pneumonia, and heightening of protein plasmatic levels pro-inflammatory driven effects.