Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil

Detalhes bibliográficos
Autor(a) principal: Engel, Amber R
Data de Publicação: 2006
Outros Autores: Vasconcelos, Pedro Fernando da Costa, McArthur, Monica A, Barrett, Alan D. T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/996
Resumo: Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.
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spelling Engel, Amber RVasconcelos, Pedro Fernando da CostaMcArthur, Monica ABarrett, Alan D. T2016-01-26T11:40:26Z2016-01-26T11:40:26Z2006ENGEL, Amber R. et al. Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil. Vacine, v. 24, n. 15, p. 2803–2809, 2006.0264-410Xhttps://patua.iec.gov.br/handle/iec/99610.1016/j.vaccine.2006.01.009Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University Of Texas Medical Branch. Department of Microbiology and Immunology. Galveston, TX, USA.The University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA / The University of Texas Medical Branch. Department of Microbiology and Immunology. Galveston, TX, USA / The University of Texas Medical Branch. Sealy Center for Vaccine Development. Galveston, TX, USA / The University of Texas Medical Branch. Center for Biodefense and Emerging Infectious Diseases. 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dc.title.pt_BR.fl_str_mv Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
title Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
spellingShingle Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
Engel, Amber R
Febre Amarela / prevenção & controle
Vacina contra Febre Amarela / classificação
Vírus da Febre Amarela / classificação
Vírus da Febre Amarela / isolamento & purificação
title_short Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
title_full Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
title_fullStr Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
title_full_unstemmed Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
title_sort Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil
author Engel, Amber R
author_facet Engel, Amber R
Vasconcelos, Pedro Fernando da Costa
McArthur, Monica A
Barrett, Alan D. T
author_role author
author2 Vasconcelos, Pedro Fernando da Costa
McArthur, Monica A
Barrett, Alan D. T
author2_role author
author
author
dc.contributor.author.fl_str_mv Engel, Amber R
Vasconcelos, Pedro Fernando da Costa
McArthur, Monica A
Barrett, Alan D. T
dc.subject.decsPrimary.pt_BR.fl_str_mv Febre Amarela / prevenção & controle
Vacina contra Febre Amarela / classificação
Vírus da Febre Amarela / classificação
Vírus da Febre Amarela / isolamento & purificação
topic Febre Amarela / prevenção & controle
Vacina contra Febre Amarela / classificação
Vírus da Febre Amarela / classificação
Vírus da Febre Amarela / isolamento & purificação
description Although the live attenuated yellow fever (YF) 17D vaccine is considered to be one of the safest vaccines in the world today, several cases of disease associated with administration of the vaccine have been reported, including YF vaccine-associated viscerotropic disease (YF-VAVD), which was first described in 1996. All YF-VAVD isolates sequenced to date have shown very little genomic change when compared to their parental vaccine strains. In this study, we report the characterization of an isolate, BeH291597 (Brazil75), from a 1975 fatal case of YF-VAVD in Brazil. Comparison of Brazil75 with the genomic sequence of the parental 17DD vaccine strain revealed two amino acid substitutions (at positions M-49 and NS4B-240) that were unique to Brazil75. Although still a rare occurrence, this isolate suggests that YF-VAVD has been present much longer than previously recognized.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2016-01-26T11:40:26Z
dc.date.available.fl_str_mv 2016-01-26T11:40:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ENGEL, Amber R. et al. Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil. Vacine, v. 24, n. 15, p. 2803–2809, 2006.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/996
dc.identifier.issn.-.fl_str_mv 0264-410X
dc.identifier.doi.-.fl_str_mv 10.1016/j.vaccine.2006.01.009
identifier_str_mv ENGEL, Amber R. et al. Characterization of a viscerotropic yellow fever vaccine variant from a patiente in Brazil. Vacine, v. 24, n. 15, p. 2803–2809, 2006.
0264-410X
10.1016/j.vaccine.2006.01.009
url https://patua.iec.gov.br/handle/iec/996
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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