Evaluation of placental glycogen storage in mild diabetic rats

Detalhes bibliográficos
Autor(a) principal: Bueno,Aline
Data de Publicação: 2010
Outros Autores: Iessi,Isabela Lovizutto, Calderon,Iracema de Mattos Paranhos, Rudge,Marilza Vieira Cunha, Santos,Carlos Eduardo Meirelles dos, Damasceno,Débora Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000200002
Resumo: PURPOSE: To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. METHODS: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) - received 100 mg streptozocin/kg in neonatal period. At day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ with glycemia between 120 and 300 mg/dL. At day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. The newborns (NB) were classified in small (SGA), appropriate (AGA) and large (LGA) for gestational age. RESULTS: Rats STZ presented higher glycemia at days 0 and 14 of pregnancy. At end of pregnancy, rats STZ showed higher proportion of NB SGA and LGA; reduced rate of NB AGA and unaltered glycemia, insulin and placental glycogen determinations. CONCLUSION: Mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.
id SBDPC-1_248aef0171df0c1e93f9e425dc4b2b7a
oai_identifier_str oai:scielo:S0102-86502010000200002
network_acronym_str SBDPC-1
network_name_str Acta Cirúrgica Brasileira (Online)
repository_id_str
spelling Evaluation of placental glycogen storage in mild diabetic ratsDiabetes MellitusInsulinPregnancy, AnimalGlycogenStreptozocinGlycemiaRatsPURPOSE: To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. METHODS: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) - received 100 mg streptozocin/kg in neonatal period. At day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ with glycemia between 120 and 300 mg/dL. At day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. The newborns (NB) were classified in small (SGA), appropriate (AGA) and large (LGA) for gestational age. RESULTS: Rats STZ presented higher glycemia at days 0 and 14 of pregnancy. At end of pregnancy, rats STZ showed higher proportion of NB SGA and LGA; reduced rate of NB AGA and unaltered glycemia, insulin and placental glycogen determinations. CONCLUSION: Mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000200002Acta Cirúrgica Brasileira v.25 n.2 2010reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502010000200002info:eu-repo/semantics/openAccessBueno,AlineIessi,Isabela LovizuttoCalderon,Iracema de Mattos ParanhosRudge,Marilza Vieira CunhaSantos,Carlos Eduardo Meirelles dosDamasceno,Débora Cristinaeng2010-10-18T00:00:00Zoai:scielo:S0102-86502010000200002Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2010-10-18T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Evaluation of placental glycogen storage in mild diabetic rats
title Evaluation of placental glycogen storage in mild diabetic rats
spellingShingle Evaluation of placental glycogen storage in mild diabetic rats
Bueno,Aline
Diabetes Mellitus
Insulin
Pregnancy, Animal
Glycogen
Streptozocin
Glycemia
Rats
title_short Evaluation of placental glycogen storage in mild diabetic rats
title_full Evaluation of placental glycogen storage in mild diabetic rats
title_fullStr Evaluation of placental glycogen storage in mild diabetic rats
title_full_unstemmed Evaluation of placental glycogen storage in mild diabetic rats
title_sort Evaluation of placental glycogen storage in mild diabetic rats
author Bueno,Aline
author_facet Bueno,Aline
Iessi,Isabela Lovizutto
Calderon,Iracema de Mattos Paranhos
Rudge,Marilza Vieira Cunha
Santos,Carlos Eduardo Meirelles dos
Damasceno,Débora Cristina
author_role author
author2 Iessi,Isabela Lovizutto
Calderon,Iracema de Mattos Paranhos
Rudge,Marilza Vieira Cunha
Santos,Carlos Eduardo Meirelles dos
Damasceno,Débora Cristina
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bueno,Aline
Iessi,Isabela Lovizutto
Calderon,Iracema de Mattos Paranhos
Rudge,Marilza Vieira Cunha
Santos,Carlos Eduardo Meirelles dos
Damasceno,Débora Cristina
dc.subject.por.fl_str_mv Diabetes Mellitus
Insulin
Pregnancy, Animal
Glycogen
Streptozocin
Glycemia
Rats
topic Diabetes Mellitus
Insulin
Pregnancy, Animal
Glycogen
Streptozocin
Glycemia
Rats
description PURPOSE: To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. METHODS: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) - received 100 mg streptozocin/kg in neonatal period. At day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ with glycemia between 120 and 300 mg/dL. At day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. The newborns (NB) were classified in small (SGA), appropriate (AGA) and large (LGA) for gestational age. RESULTS: Rats STZ presented higher glycemia at days 0 and 14 of pregnancy. At end of pregnancy, rats STZ showed higher proportion of NB SGA and LGA; reduced rate of NB AGA and unaltered glycemia, insulin and placental glycogen determinations. CONCLUSION: Mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000200002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000200002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502010000200002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.25 n.2 2010
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
_version_ 1752126439940947968