Evaluation of placental glycogen storage in mild diabetic rats

Detalhes bibliográficos
Autor(a) principal: Bueno, Aline [UNESP]
Data de Publicação: 2010
Outros Autores: Iessi, Isabela Lovizutto [UNESP], Calderon, Iracema de Mattos Paranhos [UNESP], Rudge, Marilza Vieira Cunha [UNESP], Meirelles dos Santos, Carlos Eduardo [UNESP], Damasceno, Débora Cristina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502010000200002
http://hdl.handle.net/11449/11115
Resumo: Purpose: To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. Methods: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) received 100 mg streptozocin/kg in neonatal period. At day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ with glycemia between 120 and 300 mg/dL. At day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. The newborns (NB) were classified in small (SGA), appropriate (AGA) and large (LGA) for gestational age. Results: Rats STZ presented higher glycemia at days 0 and 14 of pregnancy. At end of pregnancy, rats STZ showed higher proportion of NB SGA and LGA; reduced rate of NB AGA and unaltered glycemia, insulin and placental glycogen determinations. Conclusion: Mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.
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spelling Evaluation of placental glycogen storage in mild diabetic ratsDiabetes MellitusInsulinPregnancy, AnimalGlycogenStreptozocinGlycemiaRatsPurpose: To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. Methods: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) received 100 mg streptozocin/kg in neonatal period. At day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ with glycemia between 120 and 300 mg/dL. At day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. The newborns (NB) were classified in small (SGA), appropriate (AGA) and large (LGA) for gestational age. Results: Rats STZ presented higher glycemia at days 0 and 14 of pregnancy. At end of pregnancy, rats STZ showed higher proportion of NB SGA and LGA; reduced rate of NB AGA and unaltered glycemia, insulin and placental glycogen determinations. Conclusion: Mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.Univ Estadual Paulista, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, São Paulo, BrazilUniv Estadual Paulista, Dept Gynecol & Obstet, Botucatu Med Sch, São Paulo, BrazilUniv Estadual Paulista, Dept Surg, Sch Vet Med Botucatu, São Paulo, BrazilBauru Vet Ctr CVB, São Paulo, BrazilUniv Estadual Paulista, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, São Paulo, BrazilUniv Estadual Paulista, Dept Gynecol & Obstet, Botucatu Med Sch, São Paulo, BrazilUniv Estadual Paulista, Dept Surg, Sch Vet Med Botucatu, São Paulo, BrazilSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Estadual Paulista (Unesp)Bauru Vet Ctr CVBBueno, Aline [UNESP]Iessi, Isabela Lovizutto [UNESP]Calderon, Iracema de Mattos Paranhos [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Meirelles dos Santos, Carlos Eduardo [UNESP]Damasceno, Débora Cristina [UNESP]2014-05-20T13:32:36Z2014-05-20T13:32:36Z2010-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article132-136application/pdfhttp://dx.doi.org/10.1590/S0102-86502010000200002Acta Cirúrgica Brasileira. São Paulo: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 25, n. 2, p. 132-136, 2010.0102-8650http://hdl.handle.net/11449/1111510.1590/S0102-86502010000200002S0102-86502010000200002WOS:000275827400002WOS000275827400002.pdf067938762260474367586803888350780000-0002-9227-832XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirúrgica Brasileira0.9330,395info:eu-repo/semantics/openAccess2023-11-29T06:11:47Zoai:repositorio.unesp.br:11449/11115Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-29T06:11:47Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of placental glycogen storage in mild diabetic rats
title Evaluation of placental glycogen storage in mild diabetic rats
spellingShingle Evaluation of placental glycogen storage in mild diabetic rats
Bueno, Aline [UNESP]
Diabetes Mellitus
Insulin
Pregnancy, Animal
Glycogen
Streptozocin
Glycemia
Rats
title_short Evaluation of placental glycogen storage in mild diabetic rats
title_full Evaluation of placental glycogen storage in mild diabetic rats
title_fullStr Evaluation of placental glycogen storage in mild diabetic rats
title_full_unstemmed Evaluation of placental glycogen storage in mild diabetic rats
title_sort Evaluation of placental glycogen storage in mild diabetic rats
author Bueno, Aline [UNESP]
author_facet Bueno, Aline [UNESP]
Iessi, Isabela Lovizutto [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Meirelles dos Santos, Carlos Eduardo [UNESP]
Damasceno, Débora Cristina [UNESP]
author_role author
author2 Iessi, Isabela Lovizutto [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Meirelles dos Santos, Carlos Eduardo [UNESP]
Damasceno, Débora Cristina [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Bauru Vet Ctr CVB
dc.contributor.author.fl_str_mv Bueno, Aline [UNESP]
Iessi, Isabela Lovizutto [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Meirelles dos Santos, Carlos Eduardo [UNESP]
Damasceno, Débora Cristina [UNESP]
dc.subject.por.fl_str_mv Diabetes Mellitus
Insulin
Pregnancy, Animal
Glycogen
Streptozocin
Glycemia
Rats
topic Diabetes Mellitus
Insulin
Pregnancy, Animal
Glycogen
Streptozocin
Glycemia
Rats
description Purpose: To evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. Methods: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) received 100 mg streptozocin/kg in neonatal period. At day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ with glycemia between 120 and 300 mg/dL. At day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. The newborns (NB) were classified in small (SGA), appropriate (AGA) and large (LGA) for gestational age. Results: Rats STZ presented higher glycemia at days 0 and 14 of pregnancy. At end of pregnancy, rats STZ showed higher proportion of NB SGA and LGA; reduced rate of NB AGA and unaltered glycemia, insulin and placental glycogen determinations. Conclusion: Mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
2014-05-20T13:32:36Z
2014-05-20T13:32:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502010000200002
Acta Cirúrgica Brasileira. São Paulo: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 25, n. 2, p. 132-136, 2010.
0102-8650
http://hdl.handle.net/11449/11115
10.1590/S0102-86502010000200002
S0102-86502010000200002
WOS:000275827400002
WOS000275827400002.pdf
0679387622604743
6758680388835078
0000-0002-9227-832X
url http://dx.doi.org/10.1590/S0102-86502010000200002
http://hdl.handle.net/11449/11115
identifier_str_mv Acta Cirúrgica Brasileira. São Paulo: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 25, n. 2, p. 132-136, 2010.
0102-8650
10.1590/S0102-86502010000200002
S0102-86502010000200002
WOS:000275827400002
WOS000275827400002.pdf
0679387622604743
6758680388835078
0000-0002-9227-832X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirúrgica Brasileira
0.933
0,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 132-136
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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